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Items: 1 to 20 of 70

1.

Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors.

Zellner C, Pullinger CR, Aouizerat BE, Frost PH, Kwok PY, Malloy MJ, Kane JP.

Hum Mutat. 2005 Jan;25(1):18-21.

PMID:
15580557
2.

Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74.

Mahboubi K, Witman-Jones T, Adamus JE, Letsinger JT, Whitehouse D, Moorman AR, Sawicki D, Bergenhem N, Ross SA.

Biochem Biophys Res Commun. 2006 Feb 10;340(2):482-90. Epub 2005 Dec 19.

PMID:
16389067
3.

Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways.

Knowles HJ, te Poele RH, Workman P, Harris AL.

Biochem Pharmacol. 2006 Feb 28;71(5):646-56. Epub 2006 Jan 18. Erratum in: Biochem Pharmacol. 2006 May 28;71(11):1662. Te Poole, Robert [corrected to te Poele, Robert H].

PMID:
16386710
4.

The high-affinity niacin receptor HM74A is decreased in the anterior cingulate cortex of individuals with schizophrenia.

Miller CL, Dulay JR.

Brain Res Bull. 2008 Sep 5;77(1):33-41. doi: 10.1016/j.brainresbull.2008.03.015. Epub 2008 Apr 22.

PMID:
18639743
5.

1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.

Semple G, Skinner PJ, Cherrier MC, Webb PJ, Sage CR, Tamura SY, Chen R, Richman JG, Connolly DT.

J Med Chem. 2006 Feb 23;49(4):1227-30.

PMID:
16480258
6.

Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A.

Zhang Y, Schmidt RJ, Foxworthy P, Emkey R, Oler JK, Large TH, Wang H, Su EW, Mosior MK, Eacho PI, Cao G.

Biochem Biophys Res Commun. 2005 Aug 26;334(2):729-32.

PMID:
16018973
7.

Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity.

Peters JU, Kühne H, Dehmlow H, Grether U, Conte A, Hainzl D, Hertel C, Kratochwil NA, Otteneder M, Narquizian R, Panousis CG, Ricklin F, Röver S.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5426-30. doi: 10.1016/j.bmcl.2010.07.108. Epub 2010 Jul 29.

PMID:
20724150
8.

Nicotinic acid (niacin) receptor agonists: will they be useful therapeutic agents?

Kamanna VS, Kashyap ML.

Am J Cardiol. 2007 Dec 3;100(11 A):S53-61. Review.

PMID:
18047854
9.

Nicotinic acid receptor subtypes and their ligands.

Soudijn W, van Wijngaarden I, Ijzerman AP.

Med Res Rev. 2007 May;27(3):417-33. Review.

PMID:
17238156
10.

Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A.

Tang Y, Zhou L, Gunnet JW, Wines PG, Cryan EV, Demarest KT.

Biochem Biophys Res Commun. 2006 Jun 23;345(1):29-37. Epub 2006 Apr 25.

PMID:
16674924
11.

Human epidermoid A431 cells express functional nicotinic acid receptor HM74a.

Zhou L, Tang Y, Cryan EV, Demarest KT.

Mol Cell Biochem. 2007 Jan;294(1-2):243-8. Epub 2006 Nov 24.

PMID:
17124637
12.

Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B.

Irukayama-Tomobe Y, Tanaka H, Yokomizo T, Hashidate-Yoshida T, Yanagisawa M, Sakurai T.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4. doi: 10.1073/pnas.0811844106. Epub 2009 Feb 23.

13.

Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G).

Tunaru S, Lättig J, Kero J, Krause G, Offermanns S.

Mol Pharmacol. 2005 Nov;68(5):1271-80. Epub 2005 Aug 11.

14.

GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.

Benyó Z, Gille A, Kero J, Csiky M, Suchánková MC, Nüsing RM, Moers A, Pfeffer K, Offermanns S.

J Clin Invest. 2005 Dec;115(12):3634-40.

15.

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.

Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S.

Nat Med. 2003 Mar;9(3):352-5. Epub 2003 Feb 3.

PMID:
12563315
16.

Evidence for constitutive dimerization of niacin receptor subtypes.

Mandrika I, Petrovska R, Klovins J.

Biochem Biophys Res Commun. 2010 Apr 30;395(2):281-7. doi: 10.1016/j.bbrc.2010.04.011. Epub 2010 Apr 7.

PMID:
20380810
17.

Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b.

Jung JK, Johnson BR, Duong T, Decaire M, Uy J, Gharbaoui T, Boatman PD, Sage CR, Chen R, Richman JG, Connolly DT, Semple G.

J Med Chem. 2007 Apr 5;50(7):1445-8. Epub 2007 Mar 15.

PMID:
17358052
18.

Catalog of 300 SNPs in 23 genes encoding G-protein coupled receptors.

Iida A, Saito S, Sekine A, Kataoka Y, Tabei W, Nakamura Y.

J Hum Genet. 2004;49(4):194-208. Epub 2004 Mar 20.

PMID:
15042431
19.

Future of GPR109A agonists in the treatment of dyslipidaemia.

Wanders D, Judd RL.

Diabetes Obes Metab. 2011 Aug;13(8):685-91. doi: 10.1111/j.1463-1326.2011.01400.x. Review.

PMID:
21418500
20.

HM74a agonists: will they be the new generation of nicotinic acid?

Martres P.

Curr Top Med Chem. 2009;9(5):428-35. Review.

PMID:
19519459

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