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Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element.

Metzen E, Stiehl DP, Doege K, Marxsen JH, Hellwig-Bürgel T, Jelkmann W.

Biochem J. 2005 May 1;387(Pt 3):711-7.


Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling.

Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Jöhren O, Fandrey J, Berchner-Pfannschmidt U, Depping R.

J Cell Sci. 2012 Nov 1;125(Pt 21):5168-76. doi: 10.1242/jcs.109041. Epub 2012 Sep 3.


Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.

Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM.

Clin Cancer Res. 2006 Feb 15;12(4):1080-7.


The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability.

Barth S, Nesper J, Hasgall PA, Wirthner R, Nytko KJ, Edlich F, Katschinski DM, Stiehl DP, Wenger RH, Camenisch G.

Mol Cell Biol. 2007 May;27(10):3758-68. Epub 2007 Mar 12.


Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene.

Pescador N, Cuevas Y, Naranjo S, Alcaide M, Villar D, Landázuri MO, Del Peso L.

Biochem J. 2005 Aug 15;390(Pt 1):189-97.


HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J.

EMBO J. 2003 Aug 15;22(16):4082-90.


Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia.

Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV.

J Biol Chem. 2012 May 11;287(20):16975-86. doi: 10.1074/jbc.M111.334466. Epub 2012 Mar 26.


Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.

Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Bürgel T, Jelkmann W, Acker H, Fandrey J.

J Cell Sci. 2003 Apr 1;116(Pt 7):1319-26.


DNA methylation analysis of the HIF-1α prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas.

Huang KT, Mikeska T, Dobrovic A, Fox SB.

Histopathology. 2010 Sep;57(3):451-60. doi: 10.1111/j.1365-2559.2010.03633.x. Epub 2010 Aug 19.


Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling.

Wollenick K, Hu J, Kristiansen G, Schraml P, Rehrauer H, Berchner-Pfannschmidt U, Fandrey J, Wenger RH, Stiehl DP.

Nucleic Acids Res. 2012 Mar;40(5):1928-43. doi: 10.1093/nar/gkr978. Epub 2011 Nov 10.


Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.

Rawluszko AA, Bujnicka KE, Horbacka K, Krokowicz P, Jagodziński PP.

BMC Cancer. 2013 Nov 6;13:526. doi: 10.1186/1471-2407-13-526.


[Reciprocal regulation between hypoxia-inducible factor-1alpha and its prolyl hydroxylases in hypoxic pulmonary hypertension rats].

Chen YR, Dai AG, Hu RC.

Zhonghua Jie He He Hu Xi Za Zhi. 2006 Oct;29(10):668-73. Chinese.


Hypoxia-inducible factor 1 transactivates the human leptin gene promoter.

Grosfeld A, Andre J, Hauguel-De Mouzon S, Berra E, Pouyssegur J, Guerre-Millo M.

J Biol Chem. 2002 Nov 8;277(45):42953-7. Epub 2002 Sep 4.


The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter.

Ding Z, Gillespie LL, Mercer FC, Paterno GD.

J Biol Chem. 2004 Jul 2;279(27):28009-16. Epub 2004 Apr 26.


Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.

Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T.

Cancer Res. 2010 Jan 1;70(1):357-66. doi: 10.1158/0008-5472.CAN-09-1876. Epub 2009 Dec 22.


Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system.

Stiehl DP, Wirthner R, Köditz J, Spielmann P, Camenisch G, Wenger RH.

J Biol Chem. 2006 Aug 18;281(33):23482-91. Epub 2006 Jun 21.


Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

Takeda K, Cowan A, Fong GH.

Circulation. 2007 Aug 14;116(7):774-81. Epub 2007 Jul 23.


The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3).

Hopfer U, Hopfer H, Jablonski K, Stahl RA, Wolf G.

J Biol Chem. 2006 Mar 31;281(13):8645-55. Epub 2006 Jan 3.


Hypoxia-dependent regulation of PHD1: cloning and characterization of the human PHD1/EGLN2 gene promoter.

Erez N, Stambolsky P, Shats I, Milyavsky M, Kachko T, Rotter V.

FEBS Lett. 2004 Jun 4;567(2-3):311-5.

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