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Items: 1 to 20 of 593

1.
2.

In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.

De Keersmaecker K, Lahortiga I, Mentens N, Folens C, Van Neste L, Bekaert S, Vandenberghe P, Odero MD, Marynen P, Cools J.

Haematologica. 2008 Apr;93(4):533-42. doi: 10.3324/haematol.11894. Epub 2008 Mar 5.

3.

Kick it up a Notch: NOTCH1 activation in T-ALL.

Gridley T.

Cancer Cell. 2004 Nov;6(5):431-2.

4.

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.

Grabher C, von Boehmer H, Look AT.

Nat Rev Cancer. 2006 May;6(5):347-59. Review.

PMID:
16612405
5.

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Weng AP, Ferrando AA, Lee W, Morris JP 4th, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC.

Science. 2004 Oct 8;306(5694):269-71.

6.

Gamma-secretase inhibitors suppress the growth of leukemia and lymphoma cells.

Kogoshi H, Sato T, Koyama T, Nara N, Tohda S.

Oncol Rep. 2007 Jul;18(1):77-80.

PMID:
17549349
7.

Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kappaB and JNK/AP-1 pathways.

Scupoli MT, Donadelli M, Cioffi F, Rossi M, Perbellini O, Malpeli G, Corbioli S, Vinante F, Krampera M, Palmieri M, Scarpa A, Ariola C, Foà R, Pizzolo G.

Haematologica. 2008 Apr;93(4):524-32. doi: 10.3324/haematol.12098. Epub 2008 Mar 5.

8.

Notch signaling in leukemia.

Aster JC, Pear WS.

Curr Opin Hematol. 2001 Jul;8(4):237-44.

PMID:
11561162
9.

Differential regulation of Notch signal transduction in leukaemia and lymphoma cells in culture.

Chiaramonte R, Calzavara E, Balordi F, Sabbadini M, Capello D, Gaidano G, Serra A, Comi P, Sherbet GV.

J Cell Biochem. 2003 Feb 15;88(3):569-77.

PMID:
12532332
10.

NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis.

Zhu YM, Zhao WL, Fu JF, Shi JY, Pan Q, Hu J, Gao XD, Chen B, Li JM, Xiong SM, Gu LJ, Tang JY, Liang H, Jiang H, Xue YQ, Shen ZX, Chen Z, Chen SJ.

Clin Cancer Res. 2006 May 15;12(10):3043-9. Erratum in: Clin Cancer Res. 2009 Feb 15;15(4):1506.

11.

New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.

Hales EC, Taub JW, Matherly LH.

Cell Signal. 2014 Jan;26(1):149-61. doi: 10.1016/j.cellsig.2013.09.021. Epub 2013 Oct 16. Review.

PMID:
24140475
12.

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.

Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R, Weng AP, Kutok JL, Aster JC, Kitajewski J.

J Biol Chem. 2004 Jul 16;279(29):30771-80. Epub 2004 May 3.

13.

Targeting promiscuous signaling pathways in cancer: another Notch in the bedpost.

Beverly LJ, Capobianco AJ.

Trends Mol Med. 2004 Dec;10(12):591-8. Review.

PMID:
15567329
14.

CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors.

Palomero T, Barnes KC, Real PJ, Glade Bender JL, Sulis ML, Murty VV, Colovai AI, Balbin M, Ferrando AA.

Leukemia. 2006 Jul;20(7):1279-87. Epub 2006 May 11.

PMID:
16688224
15.

Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.

Chan SM, Weng AP, Tibshirani R, Aster JC, Utz PJ.

Blood. 2007 Jul 1;110(1):278-86. Epub 2007 Mar 15.

16.

Notch in T-ALL: new players in a complex disease.

Koch U, Radtke F.

Trends Immunol. 2011 Sep;32(9):434-42. doi: 10.1016/j.it.2011.06.005. Epub 2011 Jul 19. Review.

PMID:
21775206
17.

[Functional analysis of notch in the pathophysiology of leukemia].

Tohda S.

Rinsho Byori. 2009 Apr;57(4):351-6. Review. Japanese.

PMID:
19489437
18.

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity.

Armstrong F, Brunet de la Grange P, Gerby B, Rouyez MC, Calvo J, Fontenay M, Boissel N, Dombret H, Baruchel A, Landman-Parker J, Roméo PH, Ballerini P, Pflumio F.

Blood. 2009 Feb 19;113(8):1730-40. doi: 10.1182/blood-2008-02-138172. Epub 2008 Nov 4.

19.

NOTCH and PI3K-AKT pathways intertwined.

Gutierrez A, Look AT.

Cancer Cell. 2007 Nov;12(5):411-3.

20.

NOTCH1 pathway: a molecular target in T-cell cancers?

Holowiecki J.

Lancet. 2005 Jan 15-21;365(9455):197-9. No abstract available.

PMID:
15652588

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