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Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.

Hill K, Krugmann S, Andrews SR, Coadwell WJ, Finan P, Welch HC, Hawkins PT, Stephens LR.

J Biol Chem. 2005 Feb 11;280(6):4166-73. Epub 2004 Nov 15.


Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers.

Mayeenuddin LH, McIntire WE, Garrison JC.

J Biol Chem. 2006 Jan 27;281(4):1913-20. Epub 2005 Nov 21.


Domain-domain interaction of P-Rex1 is essential for the activation and inhibition by G protein betagamma subunits and PKA.

Urano D, Nakata A, Mizuno N, Tago K, Itoh H.

Cell Signal. 2008 Aug;20(8):1545-54. doi: 10.1016/j.cellsig.2008.04.009. Epub 2008 Apr 24.


Purification of P-Rex1 from neutrophils and nucleotide exchange assay.

Hill K, Welch HC.

Methods Enzymol. 2006;406:26-41.


Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase.

Barber MA, Donald S, Thelen S, Anderson KE, Thelen M, Welch HC.

J Biol Chem. 2007 Oct 12;282(41):29967-76. Epub 2007 Aug 13.


Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins.

Cervantes-Villagrana RD, Adame-García SR, García-Jiménez I, Color-Aparicio VM, Beltrán-Navarro YM, König GM, Kostenis E, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J.

J Biol Chem. 2019 Jan 11;294(2):531-546. doi: 10.1074/jbc.RA118.006254. Epub 2018 Nov 16.


P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.

Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, Erdjument-Bromage H, Tempst P, Hawkins PT, Stephens LR.

Cell. 2002 Mar 22;108(6):809-21.


Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells.

Nie B, Cheng N, Dinauer MC, Ye RD.

Cell Signal. 2010 May;22(5):770-82. doi: 10.1016/j.cellsig.2010.01.001. Epub 2010 Jan 13.


The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.

Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM.

J Biol Chem. 2015 Aug 21;290(34):20827-40. doi: 10.1074/jbc.M115.660456. Epub 2015 Jun 24.


Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.

Pan D, Barber MA, Hornigold K, Baker MJ, Toth JM, Oxley D, Welch HC.

J Biol Chem. 2016 Mar 18;291(12):6359-75. doi: 10.1074/jbc.M115.686592. Epub 2016 Jan 20.


Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.

Cash JN, Davis EM, Tesmer JJG.

Structure. 2016 May 3;24(5):730-740. doi: 10.1016/j.str.2016.02.022. Epub 2016 Apr 14.


Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING.

Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S, Taylor SS, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J.

J Biol Chem. 2016 Mar 18;291(12):6182-99. doi: 10.1074/jbc.M115.712216. Epub 2016 Jan 21.


cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits.

Adame-García SR, Cervantes-Villagrana RD, Orduña-Castillo LB, Del Rio JC, Gutkind JS, Reyes-Cruz G, Taylor SS, Vázquez-Prado J.

J Biol Chem. 2019 Feb 15;294(7):2232-2246. doi: 10.1074/jbc.RA118.006691. Epub 2018 Dec 10.


The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α.

Barber MA, Hendrickx A, Beullens M, Ceulemans H, Oxley D, Thelen S, Thelen M, Bollen M, Welch HC.

Biochem J. 2012 Apr 1;443(1):173-83. doi: 10.1042/BJ20112078.


PLEKHG2 promotes heterotrimeric G protein βγ-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization.

Runne C, Chen S.

Mol Cell Biol. 2013 Nov;33(21):4294-307. doi: 10.1128/MCB.00879-13. Epub 2013 Sep 3.


Intrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-β Exposes a Gβγ Protein Binding Site.

Kadamur G, Ross EM.

J Biol Chem. 2016 May 20;291(21):11394-406. doi: 10.1074/jbc.M116.723940. Epub 2016 Mar 21.


G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.

Niu J, Profirovic J, Pan H, Vaiskunaite R, Voyno-Yasenetskaya T.

Circ Res. 2003 Oct 31;93(9):848-56. Epub 2003 Sep 25.


Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.

Ugolev Y, Berdichevsky Y, Weinbaum C, Pick E.

J Biol Chem. 2008 Aug 8;283(32):22257-71. doi: 10.1074/jbc.M800734200. Epub 2008 May 27.


The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2.

Lodowski DT, Barnhill JF, Pyskadlo RM, Ghirlando R, Sterne-Marr R, Tesmer JJ.

Biochemistry. 2005 May 10;44(18):6958-70.


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