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Items: 1 to 20 of 99


Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes.

Lovett-Racke AE, Rocchini AE, Choy J, Northrop SC, Hussain RZ, Ratts RB, Sikder D, Racke MK.

Immunity. 2004 Nov;21(5):719-31.


T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells.

Afkarian M, Sedy JR, Yang J, Jacobson NG, Cereb N, Yang SY, Murphy TL, Murphy KM.

Nat Immunol. 2002 Jun;3(6):549-57. Epub 2002 May 13.


Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis.

Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK.

J Exp Med. 2004 Jul 5;200(1):79-87.


Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27.

Morishima N, Owaki T, Asakawa M, Kamiya S, Mizuguchi J, Yoshimoto T.

J Immunol. 2005 Aug 1;175(3):1686-93.


Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor.

Harris DP, Goodrich S, Gerth AJ, Peng SL, Lund FE.

J Immunol. 2005 Jun 1;174(11):6781-90.


T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity.

Gocke AR, Cravens PD, Ben LH, Hussain RZ, Northrop SC, Racke MK, Lovett-Racke AE.

J Immunol. 2007 Feb 1;178(3):1341-8.


In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment.

Durali D, de Goër de Herve MG, Giron-Michel J, Azzarone B, Delfraissy JF, Taoufik Y.

Blood. 2003 Dec 1;102(12):4084-9. Epub 2003 Jul 31.


Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals.

Yang Y, Ochando JC, Bromberg JS, Ding Y.

Blood. 2007 Oct 1;110(7):2494-500. Epub 2007 Jun 15.


An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells.

Kamiya S, Owaki T, Morishima N, Fukai F, Mizuguchi J, Yoshimoto T.

J Immunol. 2004 Sep 15;173(6):3871-7.


IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.

Lucas S, Ghilardi N, Li J, de Sauvage FJ.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15047-52. Epub 2003 Dec 1.


T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.

Usui T, Preiss JC, Kanno Y, Yao ZJ, Bream JH, O'Shea JJ, Strober W.

J Exp Med. 2006 Mar 20;203(3):755-66. Epub 2006 Mar 6. Erratum in: J Exp Med. 2006 Apr 17;203(4):1129.


Activated STAT4 and a functional role for IL-12 in human Peyer's patches.

Monteleone G, Holloway J, Salvati VM, Pender SL, Fairclough PD, Croft N, MacDonald TT.

J Immunol. 2003 Jan 1;170(1):300-7.


Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12.

Schulz EG, Mariani L, Radbruch A, Höfer T.

Immunity. 2009 May;30(5):673-83. doi: 10.1016/j.immuni.2009.03.013. Epub 2009 Apr 30.


Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway.

Afanasyeva M, Wang Y, Kaya Z, Stafford EA, Dohmen KM, Sadighi Akha AA, Rose NR.

Circulation. 2001 Dec 18;104(25):3145-51.


Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.

Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H.

J Immunol. 2003 May 15;170(10):4886-90.


Intestinal irradiation and fibrosis in a Th1-deficient environment.

Linard C, Billiard F, Benderitter M.

Int J Radiat Oncol Biol Phys. 2012 Sep 1;84(1):266-73. doi: 10.1016/j.ijrobp.2011.11.027. Epub 2012 Feb 13.


Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa.

Monteleone I, Monteleone G, Del Vecchio Blanco G, Vavassori P, Cucchiara S, MacDonald TT, Pallone F.

Gut. 2004 Aug;53(8):1090-5.

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