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Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.

Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A.

Nature. 2004 Dec 16;432(7019):917-21. Epub 2004 Nov 7.


Cell biology: iron thievery.

Barasch J, Mori K.

Nature. 2004 Dec 16;432(7019):811-3. No abstract available.


Lipocalin 2 is protective against E. coli pneumonia.

Wu H, Santoni-Rugiu E, Ralfkiaer E, Porse BT, Moser C, Høiby N, Borregaard N, Cowland JB.

Respir Res. 2010 Jul 15;11:96. doi: 10.1186/1465-9921-11-96.


Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection.

Liu Z, Reba S, Chen WD, Porwal SK, Boom WH, Petersen RB, Rojas R, Viswanathan R, Devireddy L.

J Exp Med. 2014 Jun 2;211(6):1197-213. doi: 10.1084/jem.20132629. Epub 2014 May 26.


The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2.

Fischbach MA, Lin H, Zhou L, Yu Y, Abergel RJ, Liu DR, Raymond KN, Wanner BL, Strong RK, Walsh CT, Aderem A, Smith KD.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16502-7. Epub 2006 Oct 23.


Interaction of lipocalin 2, transferrin, and siderophores determines the replicative niche of Klebsiella pneumoniae during pneumonia.

Bachman MA, Lenio S, Schmidt L, Oyler JE, Weiser JN.

MBio. 2012 Nov 20;3(6). pii: e00224-11. doi: 10.1128/mBio.00224-11.


Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.

Berger T, Togawa A, Duncan GS, Elia AJ, You-Ten A, Wakeham A, Fong HE, Cheung CC, Mak TW.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1834-9. Epub 2006 Jan 30.


Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin.

Bachman MA, Miller VL, Weiser JN.

PLoS Pathog. 2009 Oct;5(10):e1000622. doi: 10.1371/journal.ppat.1000622. Epub 2009 Oct 16.


Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition.

Miethke M, Skerra A.

Antimicrob Agents Chemother. 2010 Apr;54(4):1580-9. doi: 10.1128/AAC.01158-09. Epub 2010 Jan 19.


The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition.

Goetz DH, Holmes MA, Borregaard N, Bluhm ME, Raymond KN, Strong RK.

Mol Cell. 2002 Nov;10(5):1033-43.


Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut.

Singh V, Yeoh BS, Xiao X, Kumar M, Bachman M, Borregaard N, Joe B, Vijay-Kumar M.

Nat Commun. 2015 May 12;6:7113. doi: 10.1038/ncomms8113.


Neutrophil gelatinase-associated lipocalin, a siderophore-binding eukaryotic protein.

Borregaard N, Cowland JB.

Biometals. 2006 Apr;19(2):211-5. Review.


Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection.

Steigedal M, Marstad A, Haug M, Damås JK, Strong RK, Roberts PL, Himpsl SD, Stapleton A, Hooton TM, Mobley HL, Hawn TR, Flo TH.

J Immunol. 2014 Dec 15;193(12):6081-9. doi: 10.4049/jimmunol.1401528. Epub 2014 Nov 14.


Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasis.

Bellmann-Weiler R, Schroll A, Engl S, Nairz M, Talasz H, Seifert M, Weiss G.

Immunobiology. 2013 Jul;218(7):969-78. doi: 10.1016/j.imbio.2012.11.004. Epub 2012 Nov 21.


Iron metabolism at the host pathogen interface: lipocalin 2 and the pathogen-associated iroA gene cluster.

Smith KD.

Int J Biochem Cell Biol. 2007;39(10):1776-80. Epub 2007 Jul 18. Review.


Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression.

Fritsche G, Nairz M, Libby SJ, Fang FC, Weiss G.

J Leukoc Biol. 2012 Aug;92(2):353-9. doi: 10.1189/jlb.1111554. Epub 2012 Jun 15.


Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia.

Schmidt-Ott KM, Mori K, Kalandadze A, Li JY, Paragas N, Nicholas T, Devarajan P, Barasch J.

Curr Opin Nephrol Hypertens. 2006 Jul;15(4):442-9. Review.


A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake.

Devireddy LR, Gazin C, Zhu X, Green MR.

Cell. 2005 Dec 29;123(7):1293-305.


α-Intercalated cells defend the urinary system from bacterial infection.

Paragas N, Kulkarni R, Werth M, Schmidt-Ott KM, Forster C, Deng R, Zhang Q, Singer E, Klose AD, Shen TH, Francis KP, Ray S, Vijayakumar S, Seward S, Bovino ME, Xu K, Takabe Y, Amaral FE, Mohan S, Wax R, Corbin K, Sanna-Cherchi S, Mori K, Johnson L, Nickolas T, D'Agati V, Lin CS, Qiu A, Al-Awqati Q, Ratner AJ, Barasch J.

J Clin Invest. 2014 Jul;124(7):2963-76. doi: 10.1172/JCI71630. Epub 2014 Jun 17. Erratum in: J Clin Invest. 2014 Dec 1;124(12):5521.

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