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Items: 1 to 20 of 92

1.

Withaferin A is a potent inhibitor of angiogenesis.

Mohan R, Hammers HJ, Bargagna-Mohan P, Zhan XH, Herbstritt CJ, Ruiz A, Zhang L, Hanson AD, Conner BP, Rougas J, Pribluda VS.

Angiogenesis. 2004;7(2):115-22.

PMID:
15516832
2.

Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: potential application to choroidal neovascularization.

Bargagna-Mohan P, Ravindranath PP, Mohan R.

Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4138-45.

3.

Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A.

Grover A, Shandilya A, Punetha A, Bisaria VS, Sundar D.

BMC Genomics. 2010 Dec 2;11 Suppl 4:S25. doi: 10.1186/1471-2164-11-S4-S25.

4.

Development of withaferin A analogs as probes of angiogenesis.

Yokota Y, Bargagna-Mohan P, Ravindranath PP, Kim KB, Mohan R.

Bioorg Med Chem Lett. 2006 May 15;16(10):2603-7. Epub 2006 Mar 2.

5.

Molecular insight in the multifunctional activities of Withaferin A.

Vanden Berghe W, Sabbe L, Kaileh M, Haegeman G, Heyninck K.

Biochem Pharmacol. 2012 Nov 15;84(10):1282-91. doi: 10.1016/j.bcp.2012.08.027. Epub 2012 Sep 6. Review.

PMID:
22981382
6.
7.

A natural anti-inflammatory enone fatty acid inhibits angiogenesis by attenuating nuclear factor-κB signaling in vascular endothelial cells.

Furuno A, Watari K, Nakamura M, Fukunaga Y, Jung JH, Ono M.

Int J Oncol. 2011 Feb;38(2):493-501. doi: 10.3892/ijo.2010.856. Epub 2010 Dec 3.

PMID:
21132269
8.

Isogambogenic acid inhibits tumour angiogenesis by suppressing Rho GTPases and vascular endothelial growth factor receptor 2 signalling pathway.

Fan Y, Peng A, He S, Shao X, Nie C, Chen L.

J Chemother. 2013 Oct;25(5):298-308. doi: 10.1179/1973947813Y.0000000079.

PMID:
24070138
9.

Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.

Kaileh M, Vanden Berghe W, Heyerick A, Horion J, Piette J, Libert C, De Keukeleire D, Essawi T, Haegeman G.

J Biol Chem. 2007 Feb 16;282(7):4253-64. Epub 2006 Dec 6.

10.

Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo.

Yang H, Wang Y, Cheryan VT, Wu W, Cui CQ, Polin LA, Pass HI, Dou QP, Rishi AK, Wali A.

PLoS One. 2012;7(8):e41214. doi: 10.1371/journal.pone.0041214. Epub 2012 Aug 17.

11.
12.

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols.

Suttana W, Mankhetkorn S, Poompimon W, Palagani A, Zhokhov S, Gerlo S, Haegeman G, Berghe WV.

Mol Cancer. 2010 May 3;9:99. doi: 10.1186/1476-4598-9-99.

13.

Hypoglycemic activity of withanolides and elicitated Withania somnifera.

Gorelick J, Rosenberg R, Smotrich A, Hanuš L, Bernstein N.

Phytochemistry. 2015 Aug;116:283-9. doi: 10.1016/j.phytochem.2015.02.029. Epub 2015 Mar 18.

PMID:
25796090
14.

Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves.

Jayaprakasam B, Zhang Y, Seeram NP, Nair MG.

Life Sci. 2003 Nov 21;74(1):125-32.

PMID:
14575818
15.

Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation.

Oh JH, Lee TJ, Kim SH, Choi YH, Lee SH, Lee JM, Kim YH, Park JW, Kwon TK.

Apoptosis. 2008 Dec;13(12):1494-504. doi: 10.1007/s10495-008-0273-y.

PMID:
19002588
16.

Thiol dependent NF-κB suppression and inhibition of T-cell mediated adaptive immune responses by a naturally occurring steroidal lactone Withaferin A.

Gambhir L, Checker R, Sharma D, Thoh M, Patil A, Degani M, Gota V, Sandur SK.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):297-312. doi: 10.1016/j.taap.2015.09.014. Epub 2015 Sep 25.

PMID:
26408225
18.

Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589.

Qian DZ, Kato Y, Shabbeer S, Wei Y, Verheul HM, Salumbides B, Sanni T, Atadja P, Pili R.

Clin Cancer Res. 2006 Jan 15;12(2):634-42.

19.

Anti-angiogenic actions of pyrrolidine dithiocarbamate, a nuclear factor kappa B inhibitor.

Morais C, Gobe G, Johnson DW, Healy H.

Angiogenesis. 2009;12(4):365-79. doi: 10.1007/s10456-009-9158-0. Epub 2009 Oct 14.

PMID:
19882112
20.

Withaferin A: a new radiosensitizer from the Indian medicinal plant Withania somnifera.

Devi PU, Akagi K, Ostapenko V, Tanaka Y, Sugahara T.

Int J Radiat Biol. 1996 Feb;69(2):193-7.

PMID:
8609455

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