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Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation.

Fang J, Chen T, Chadwick B, Li E, Zhang Y.

J Biol Chem. 2004 Dec 17;279(51):52812-5. Epub 2004 Oct 26.


Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.

de Napoles M, Mermoud JE, Wakao R, Tang YA, Endoh M, Appanah R, Nesterova TB, Silva J, Otte AP, Vidal M, Koseki H, Brockdorff N.

Dev Cell. 2004 Nov;7(5):663-76.


Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.

van der Stoop P, Boutsma EA, Hulsman D, Noback S, Heimerikx M, Kerkhoven RM, Voncken JW, Wessels LF, van Lohuizen M.

PLoS One. 2008 May 21;3(5):e2235. doi: 10.1371/journal.pone.0002235.


Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing.

Schoeftner S, Sengupta AK, Kubicek S, Mechtler K, Spahn L, Koseki H, Jenuwein T, Wutz A.

EMBO J. 2006 Jul 12;25(13):3110-22. Epub 2006 Jun 8.


Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.

Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M.

Proc Natl Acad Sci U S A. 2005 May 24;102(21):7635-40. Epub 2005 May 16.


Role of histone H2A ubiquitination in Polycomb silencing.

Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y.

Nature. 2004 Oct 14;431(7010):873-8. Epub 2004 Sep 22.


Role of histone H3 lysine 27 methylation in X inactivation.

Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B, Zhang Y.

Science. 2003 Apr 4;300(5616):131-5. Epub 2003 Mar 20.


Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.

Buchwald G, van der Stoop P, Weichenrieder O, Perrakis A, van Lohuizen M, Sixma TK.

EMBO J. 2006 Jun 7;25(11):2465-74. Epub 2006 May 18.


Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression.

Vidal M.

Int J Dev Biol. 2009;53(2-3):355-70. doi: 10.1387/ijdb.082690mv. Review.


The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity.

Ben-Saadon R, Zaaroor D, Ziv T, Ciechanover A.

Mol Cell. 2006 Dec 8;24(5):701-711. doi: 10.1016/j.molcel.2006.10.022.


Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome.

Zaaroor-Regev D, de Bie P, Scheffner M, Noy T, Shemer R, Heled M, Stein I, Pikarsky E, Ciechanover A.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6788-93. doi: 10.1073/pnas.1003108107. Epub 2010 Mar 29.


Characterization of Histone Modifications Associated with Inactive X-Chromosome in Trophoblast Stem Cells, eXtra-Embryonic Endoderm Cells and in In Vitro Derived Undifferentiated and Differentiated Epiblast Like Stem Cells.

Dupont C, Maduro C, Den Braanker H, Boers R, Kurek D, Gribnau J.

PLoS One. 2016 Dec 15;11(12):e0167154. doi: 10.1371/journal.pone.0167154. eCollection 2016.


A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin.

Elderkin S, Maertens GN, Endoh M, Mallery DL, Morrice N, Koseki H, Peters G, Brockdorff N, Hiom K.

Mol Cell. 2007 Oct 12;28(1):107-20.


Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex.

Li Z, Cao R, Wang M, Myers MP, Zhang Y, Xu RM.

J Biol Chem. 2006 Jul 21;281(29):20643-9. Epub 2006 May 18.


Ubiquitinated proteins including uH2A on the human and mouse inactive X chromosome: enrichment in gene rich bands.

Smith KP, Byron M, Clemson CM, Lawrence JB.

Chromosoma. 2004 Dec;113(6):324-35. Epub 2004 Nov 20.


Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome.

Plath K, Talbot D, Hamer KM, Otte AP, Yang TP, Jaenisch R, Panning B.

J Cell Biol. 2004 Dec 20;167(6):1025-35. Epub 2004 Dec 13.


ATRX marks the inactive X chromosome (Xi) in somatic cells and during imprinted X chromosome inactivation in trophoblast stem cells.

Baumann C, De La Fuente R.

Chromosoma. 2009 Apr;118(2):209-22. doi: 10.1007/s00412-008-0189-x. Epub 2008 Nov 13.


Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells.

Mak W, Baxter J, Silva J, Newall AE, Otte AP, Brockdorff N.

Curr Biol. 2002 Jun 25;12(12):1016-20.


UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination.

An JY, Kim EA, Jiang Y, Zakrzewska A, Kim DE, Lee MJ, Mook-Jung I, Zhang Y, Kwon YT.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1912-7. doi: 10.1073/pnas.0910267107. Epub 2010 Jan 11.

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