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Items: 1 to 20 of 115

1.

TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.

Ea CK, Sun L, Inoue J, Chen ZJ.

Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15318-23. Epub 2004 Oct 18.

2.

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.

Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ.

Mol Cell. 2004 May 7;14(3):289-301.

3.

Direct activation of protein kinases by unanchored polyubiquitin chains.

Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ.

Nature. 2009 Sep 3;461(7260):114-9. doi: 10.1038/nature08247. Epub 2009 Aug 12.

4.

TAK1 is a ubiquitin-dependent kinase of MKK and IKK.

Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ.

Nature. 2001 Jul 19;412(6844):346-51.

PMID:
11460167
5.

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

Lamothe B, Besse A, Campos AD, Webster WK, Wu H, Darnay BG.

J Biol Chem. 2007 Feb 9;282(6):4102-12. Epub 2006 Nov 29.

6.

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.

Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ.

Cell. 2000 Oct 13;103(2):351-61.

7.

TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.

Kishida S, Sanjo H, Akira S, Matsumoto K, Ninomiya-Tsuji J.

Genes Cells. 2005 May;10(5):447-54.

8.

A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.

Hinz M, Stilmann M, Arslan SÇ, Khanna KK, Dittmar G, Scheidereit C.

Mol Cell. 2010 Oct 8;40(1):63-74. doi: 10.1016/j.molcel.2010.09.008.

9.

The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination.

Yang K, Zhu J, Sun S, Tang Y, Zhang B, Diao L, Wang C.

Biochem Biophys Res Commun. 2004 Nov 5;324(1):432-9.

PMID:
15465037
10.

The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL.

Lamothe B, Campos AD, Webster WK, Gopinathan A, Hur L, Darnay BG.

J Biol Chem. 2008 Sep 5;283(36):24871-80. doi: 10.1074/jbc.M802749200. Epub 2008 Jul 10.

11.

Oligomerization-primed coiled-coil domain interaction with Ubc13 confers processivity to TRAF6 ubiquitin ligase activity.

Hu L, Xu J, Xie X, Zhou Y, Tao P, Li H, Han X, Wang C, Liu J, Xu P, Neculai D, Xia Z.

Nat Commun. 2017 Oct 9;8(1):814. doi: 10.1038/s41467-017-01290-0.

12.

Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3.

Zhang J, Macartney T, Peggie M, Cohen P.

Biochem J. 2017 Jun 26;474(13):2235-2248. doi: 10.1042/BCJ20170288.

13.

Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling.

Takatsuna H, Kato H, Gohda J, Akiyama T, Moriya A, Okamoto Y, Yamagata Y, Otsuka M, Umezawa K, Semba K, Inoue J.

J Biol Chem. 2003 Apr 4;278(14):12144-50. Epub 2003 Feb 3.

14.

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.

Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ.

Mol Cell. 2004 Aug 27;15(4):535-48.

15.

Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling.

Moon G, Kim J, Min Y, Wi SM, Shim JH, Chun E, Lee KY.

Cell Signal. 2015 Dec;27(12):2524-33. doi: 10.1016/j.cellsig.2015.09.018. Epub 2015 Sep 30.

PMID:
26432169
16.

TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation.

Mao R, Fan Y, Mou Y, Zhang H, Fu S, Yang J.

Cell Signal. 2011 Jan;23(1):222-7. doi: 10.1016/j.cellsig.2010.09.006. Epub 2010 Sep 16.

17.

TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.

Morlon A, Munnich A, Smahi A.

Hum Mol Genet. 2005 Dec 1;14(23):3751-7. Epub 2005 Oct 26.

PMID:
16251197
18.

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.

Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N, Zhang S, Heldin CH, Landström M.

Nat Cell Biol. 2008 Oct;10(10):1199-207. doi: 10.1038/ncb1780. Epub 2008 Aug 31.

PMID:
18758450
19.

Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.

Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N.

Mol Cell Biol. 2002 Feb;22(4):992-1000.

20.

MEKK3 and TAK1 synergize to activate IKK complex in Helicobacter pylori infection.

Sokolova O, Maubach G, Naumann M.

Biochim Biophys Acta. 2014 Apr;1843(4):715-24. doi: 10.1016/j.bbamcr.2014.01.006. Epub 2014 Jan 11.

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