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Items: 1 to 20 of 227

1.

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.

Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C.

J Clin Invest. 2004 Oct;114(8):1158-64.

2.

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.

Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD.

Nature. 2015 Apr 2;520(7545):94-8. doi: 10.1038/nature14051. Epub 2015 Jan 19.

3.

Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.

Wilczynski A, Wang XS, Joseph CG, Xiang Z, Bauzo RM, Scott JW, Sorensen NB, Shaw AM, Millard WJ, Richards NG, Haskell-Luevano C.

J Med Chem. 2004 Apr 22;47(9):2194-207.

PMID:
15084118
4.

Activation of MAPK by inverse agonists in six naturally occurring constitutively active mutant human melanocortin-4 receptors.

Mo XL, Tao YX.

Biochim Biophys Acta. 2013 Dec;1832(12):1939-48. doi: 10.1016/j.bbadis.2013.06.006. Epub 2013 Jun 18.

5.

Molecular basis of melanocortin-4 receptor for AGRP inverse agonism.

Chen M, Celik A, Georgeson KE, Harmon CM, Yang Y.

Regul Pept. 2006 Sep 11;136(1-3):40-9. Epub 2006 Jul 3.

PMID:
16820227
6.

Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax).

Sánchez E, Rubio VC, Thompson D, Metz J, Flik G, Millhauser GL, Cerdá-Reverter JM.

Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1293-306. doi: 10.1152/ajpregu.90948.2008. Epub 2009 Feb 18.

7.
8.

Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.

Xiang Z, Litherland SA, Sorensen NB, Proneth B, Wood MS, Shaw AM, Millard WJ, Haskell-Luevano C.

Biochemistry. 2006 Jun 13;45(23):7277-88.

PMID:
16752916
10.

The interaction of MC3R and MC4R with MRAP2, ACTH, α-MSH and AgRP in chickens.

Zhang J, Li X, Zhou Y, Cui L, Li J, Wu C, Wan Y, Li J, Wang Y.

J Endocrinol. 2017 Aug;234(2):155-174. doi: 10.1530/JOE-17-0131. Epub 2017 May 16.

PMID:
28512117
11.

Constitutive activity in melanocortin-4 receptor: biased signaling of inverse agonists.

Tao YX.

Adv Pharmacol. 2014;70:135-54. doi: 10.1016/B978-0-12-417197-8.00005-5. Review.

PMID:
24931195
12.

Melanocortin 4 receptor ligands modulate energy homeostasis through urocortin 1 neurons of the centrally projecting Edinger-Westphal nucleus.

Füredi N, Nagy Á, Mikó A, Berta G, Kozicz T, Pétervári E, Balaskó M, Gaszner B.

Neuropharmacology. 2017 May 15;118:26-37. doi: 10.1016/j.neuropharm.2017.03.002. Epub 2017 Mar 3.

PMID:
28267582
13.

Role of third intracellular loop of the melanocortin 4 receptor in the regulation of constitutive activity.

Kim DH, Shin SW, Baik JH.

Biochem Biophys Res Commun. 2008 Jan 18;365(3):439-45. Epub 2007 Nov 5.

PMID:
17986382
14.

Exposure of MC4R to agonist in the endoplasmic reticulum stabilizes an active conformation of the receptor that does not desensitize.

Granell S, Molden BM, Baldini G.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4733-42. doi: 10.1073/pnas.1219808110. Epub 2013 Nov 18.

15.
16.

Molecular determination of agouti-related protein binding to human melanocortin-4 receptor.

Yang Y, Chen M, Lai Y, Gantz I, Yagmurlu A, Georgeson KE, Harmon CM.

Mol Pharmacol. 2003 Jul;64(1):94-103.

17.

Common requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein.

Oosterom J, Garner KM, den Dekker WK, Nijenhuis WA, Gispen WH, Burbach JP, Barsh GS, Adan RA.

J Biol Chem. 2001 Jan 12;276(2):931-6.

18.
19.

Pertussis toxin-sensitive signaling of melanocortin-4 receptors in hypothalamic GT1-7 cells defines agouti-related protein as a biased agonist.

Büch TR, Heling D, Damm E, Gudermann T, Breit A.

J Biol Chem. 2009 Sep 25;284(39):26411-20. doi: 10.1074/jbc.M109.039339. Epub 2009 Jul 31.

20.

Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).

Singh A, Dirain ML, Wilczynski A, Chen C, Gosnell BA, Levine AS, Edison AS, Haskell-Luevano C.

ACS Chem Neurosci. 2014 Oct 15;5(10):1020-31. doi: 10.1021/cn5000953. Epub 2014 Aug 26.

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