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Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.

Wang X, Yue P, Chan CB, Ye K, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Fu H, Khuri FR, Sun SY.

Mol Cell Biol. 2007 Nov;27(21):7405-13. Epub 2007 Aug 27.


Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes.

Kudchodkar SB, Yu Y, Maguire TG, Alwine JC.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14182-7. Epub 2006 Sep 7.


Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.

Otulakowski G, Duan W, Gandhi S, O'brodovich H.

Am J Respir Cell Mol Biol. 2007 Oct;37(4):457-66. Epub 2007 Jun 7.


The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection.

Clippinger AJ, Maguire TG, Alwine JC.

J Virol. 2011 Apr;85(8):3930-9. doi: 10.1128/JVI.01913-10. Epub 2011 Feb 9.


Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, Khuri FR.

Cancer Res. 2005 Aug 15;65(16):7052-8.


MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle.

Hu SI, Katz M, Chin S, Qi X, Cruz J, Ibebunjo C, Zhao S, Chen A, Glass DJ.

Sci Signal. 2012 Feb 14;5(211):ra14. doi: 10.1126/scisignal.2002466.


The rapid activation of protein synthesis by growth hormone requires signaling through mTOR.

Hayashi AA, Proud CG.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1647-55. Epub 2007 Feb 6.


Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle.

Lang CH, Frost RA, Deshpande N, Kumar V, Vary TC, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1205-15. Epub 2003 Aug 26.


Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling.

Vary TC, Deiter G, Goodman SA.

Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H121-8. Epub 2004 Sep 23.


Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress.

Naegele S, Morley SJ.

J Biol Chem. 2004 Oct 29;279(44):46023-34. Epub 2004 Aug 3.


Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication.

Moorman NJ, Shenk T.

J Virol. 2010 May;84(10):5260-9. doi: 10.1128/JVI.02733-09. Epub 2010 Feb 24.


ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells.

Hafizi S, Wang X, Chester AH, Yacoub MH, Proud CG.

Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1232-8.


Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.

Ikezoe T, Nishioka C, Bandobashi K, Yang Y, Kuwayama Y, Adachi Y, Takeuchi T, Koeffler HP, Taguchi H.

Leuk Res. 2007 May;31(5):673-82. Epub 2006 Sep 27.


Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle.

Bolster DR, Kubica N, Crozier SJ, Williamson DL, Farrell PA, Kimball SR, Jefferson LS.

J Physiol. 2003 Nov 15;553(Pt 1):213-20. Epub 2003 Aug 22.


Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.

Dennis MD, Jefferson LS, Kimball SR.

J Biol Chem. 2012 Dec 14;287(51):42890-9. doi: 10.1074/jbc.M112.404822. Epub 2012 Oct 26.

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