Similar articles for PMID: 15380204

Year	Number of Results
2003	2
2004	15
2005	10
2006	13
2007	8
2008	12
2009	12
2010	11
2011	9
2012	13
2013	9
2014	11
2015	3
2016	4
2017	1
2018	1
2019	2
2020	3
2024	0

1

Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid.

Stansfield I, Avolio S, Colarusso S, Gennari N, Narjes F, Pacini B, Ponzi S, Harper S. Stansfield I, et al. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5085-8. doi: 10.1016/j.bmcl.2004.07.075. Bioorg Med Chem Lett. 2004. PMID: 15380204

2

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

Koch U, Attenni B, Malancona S, Colarusso S, Conte I, Di Filippo M, Harper S, Pacini B, Giomini C, Thomas S, Incitti I, Tomei L, De Francesco R, Altamura S, Matassa VG, Narjes F. Koch U, et al. J Med Chem. 2006 Mar 9;49(5):1693-705. doi: 10.1021/jm051064t. J Med Chem. 2006. PMID: 16509585

3

2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.

Pacini B, Avolio S, Ercolani C, Koch U, Migliaccio G, Narjes F, Pacini L, Tomei L, Harper S. Pacini B, et al. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6245-9. doi: 10.1016/j.bmcl.2009.06.106. Epub 2009 Jul 17. Bioorg Med Chem Lett. 2009. PMID: 19800789

4

HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY.

Yannopoulos CG, Xu P, Ni F, Chan L, Pereira OZ, Reddy TJ, Das SK, Poisson C, Nguyen-Ba N, Turcotte N, Proulx M, Halab L, Wang W, Bédard J, Morin N, Hamel M, Nicolas O, Bilimoria D, L'Heureux L, Bethell R, Dionne G. Yannopoulos CG, et al. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5333-7. doi: 10.1016/j.bmcl.2004.08.018. Bioorg Med Chem Lett. 2004. PMID: 15454222

5

Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors.

Barnes-Seeman D, Boiselle C, Capacci-Daniel C, Chopra R, Hoffmaster K, Jones CT, Kato M, Lin K, Ma S, Pan G, Shu L, Wang J, Whiteman L, Xu M, Zheng R, Fu J. Barnes-Seeman D, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3979-85. doi: 10.1016/j.bmcl.2014.06.031. Epub 2014 Jun 20. Bioorg Med Chem Lett. 2014. PMID: 24986660

6

HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.

Summa V, Petrocchi A, Matassa VG, Taliani M, Laufer R, De Francesco R, Altamura S, Pace P. Summa V, et al. J Med Chem. 2004 Oct 21;47(22):5336-9. doi: 10.1021/jm0494669. J Med Chem. 2004. PMID: 15481971

7

Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.

Yang H, Hendricks RT, Arora N, Nitzan D, Yee C, Lucas MC, Yang Y, Fung A, Rajyaguru S, Harris SF, Leveque VJ, Hang JQ, Pogam SL, Reuter D, Tavares GA. Yang H, et al. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4614-9. doi: 10.1016/j.bmcl.2010.06.008. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20584604

8

Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines.

Powdrill MH, Deval J, Narjes F, De Francesco R, Götte M. Powdrill MH, et al. Antimicrob Agents Chemother. 2010 Mar;54(3):977-83. doi: 10.1128/AAC.01216-09. Epub 2009 Dec 22. Antimicrob Agents Chemother. 2010. PMID: 20028820 Free PMC article.

9

Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.

Patel BA, Krishnan R, Khadtare N, Gurukumar KR, Basu A, Arora P, Bhatt A, Patel MR, Dana D, Kumar S, Kaushik-Basu N, Talele TT. Patel BA, et al. Bioorg Med Chem. 2013 Jun 1;21(11):3262-71. doi: 10.1016/j.bmc.2013.03.041. Epub 2013 Mar 31. Bioorg Med Chem. 2013. PMID: 23598249 Free PMC article.

10

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides.

Chan L, Das SK, Reddy TJ, Poisson C, Proulx M, Pereira O, Courchesne M, Roy C, Wang W, Siddiqui A, Yannopoulos CG, Nguyen-Ba N, Labrecque D, Bethell R, Hamel M, Courtemanche-Asselin P, L'Heureux L, David M, Nicolas O, Brunette S, Bilimoria D, Bédard J. Chan L, et al. Bioorg Med Chem Lett. 2004 Feb 9;14(3):793-6. doi: 10.1016/j.bmcl.2003.10.067. Bioorg Med Chem Lett. 2004. PMID: 14741291

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