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15339967,15907365,15339958,15650234,12234979,12858336,21237137,15909111,11431347,14612528,12388538,25240837,16131844,12051721,10393722,17498692,15271800,16122660,16691498,11106681,14647238,21592087,16540676,26220867,19932170,14569872,11010810,28322796,10037475,17239851,12208520,21932365,15911980,19937735,11822871,15289350,15837770,16923157,10200470,8597588,21964808,21705667,20836852,17216584,23052481,19240026,17329567,16624283,16626961,9813032,17685585,15088070,14720208,11313880,16565407,15865936,16850162,11675414,1394196,11156942,9716505,17353921,15781658,14766899,23132899,8906572,18425327,8863486,18838947,12648232,28179290,22918683,10187863,24829158,12880976,11034356,11354249,19331667,9724094,9596684,21072519,10330437,9240970,28179144,23181473,21984552,9930722,25754045,26855418,9092523,11274971,19240275,9500792,16091745,9287216,16189296,27530131,27453200,12106819,16547352,21408067,24253178,8995443,16960033,10393709,8665849,29642569,10864654,15582204,10862608,12672022,19711353,11483862,28490444,22764099,22428532,10463940,12130682,21871207,12467215,25855965,20110363,11118669,18400537,14602806,26843908,11154079,15546881,15077187,10806317,17283068,10899928,29702255,23936132,16571915,27571014,7852361,19941060,28420138,1834639,29769046,25266739,14973367,22452947,36575190,11093824,20502003,19137010,26605090,15383576,20935456,10713077,21554198,22372555,21388949,16303764,26548718,18768882,12736045,32028642,12110272,17596294,36894641,31778304,8641566,9781285,27221045,10727527,15452132,10421266,23314735,8846779,15263008,26115843,9092485,32291318,23372815,25168245,21294641,19519377,12118012,15509740,9668353,10734114,15548711,19482076,15705795,15505623,12880975,25562160,11391632,8670233,19395669,11574545,12559195,19349362,16524368,26318452,21629700,19609004,11502879,27154977,12586734,12486134,21878749,18612046,26010541,8741670,15090729,18678863,19416641,17556754,28389107,21436125,29329781,9531498,18359942,10531389,12220574,12374208,14563412,11107142,11278517,12069099,10653586,16546973,27479697,11220788,20631069,28277984,15961787,24951586,26200918,15346652,18676372,17576160,22502731,11509673,11335714,2149853,21389273,9556584,22906436,11311151,9810222,28577326,9455907,10945987,2745431,34951654,31935967,20552297,16775254,10639587,32144381,17827720,22103431,14592454,24735752,7775872,12692077,9632721,21949119,32770509,30251395,31138648,11278294,32273493,8626522,30060818,10438487,15144238,23342165,31972222,14704790,15469694,8278410,29649738,25724183,16787381,12855704,19429679,26492941,7547879,21519903,9616175,12435813,28288862,22532571,11451199,14580684,12600263,28357533,8530509,11796243,14970205,30326559,28283474,19826105,12531551,17762163,34987511,8910670,20448054,14552757,23290777,11894136,22230689,29949159,20919648,2031938,12020635,20333722,16026301,30670592,24982331,25975536,11132185,16178418,27702691,19763526,20808818,12473648,9988695,28695226,11514235,21119025,11001568,31489901,23725018,14523050,28806500,24694597,22488330,19912993,15051724,9512367,7925994,19446953,29031494,7592930,21781990,26930027,26511776,15772421,28238856,32982239,29908366,24817993,24457089,10101287,10329660,17428232,12479368,25069047,22387616,22974251,9096651,27391427,33684145,12486096,16278342,25465297,25437839,33414455,17996206,10625655,33355876,7523573,12019315,23267130,22174837,29203804,11597471,22474281,23919551,20941382,11465070,8898887,15454695,19276353,18245173,10962439,18162584,11093963,34202192,7634330,12531552,34674560,10810929,15229396,19279011,12531544,9006952,22328778,35810485,19454701,12856718,19844581,10484606,20103619,8706124,30816675,22592846,7982960,9207084,15832819,30367436,22890197,18033322,30300355,31927048,9563272,23074226,22879933,21536668,12147222,10439466,28745666,12882362,9453539,29867196,32307766,20890432,32705968,19147160,11849746,31988047,29436609,20629193,8906574,8662871,27475812,35203316,20224005,18299447,30854677,8127917,15210713,12951083,23319743,1827738,18040843,32466233,6091759,1827496,30555632,26280656,12769772,9299410,33624234,29343457,35660779,8040893,30197917,19372594,25423171,35739089,22349266,11387262,27622309,10818445,10823942,8199203,9096129,29076348,27288875,8737258,28592871,22710568,28557389,28955042,11456220,10841826,30455063,24192821,20502000,8418889,19801523,12470841,27399265,17287460,23135722,36045177,36824365,23290776,31721713,9692614,36929117,9668355,32981286,8748167,29924725,7806975,30702345,22532987,17889095,34694057,12270134,23625371,7945993,19184418,36838715,31611597,27341515,20919646,34073578,35267607,19337026,34502192,36831084,10859325,19345744,22466649,12401200,33090522,19458475,23563657,9384796,1145196,12032669,11392536,30401902,21807667,20352118,33647448,12839955,10869565,30245960,24979136,11971953,27398923,33798648,17939778,25859016,12880979,24822250,27180613,6633174,31480447,10563309,27980577,29558805,36037065,6444773,24260592,29610685,30953657,12482429,30921693,10470676,10376687,11411990,11971858,19127120,12430179,10563341,31577206,35455428,15635045,16457613,32298582,20844597,2050199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Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.

Lovat PE, Di Sano F, Corazzari M, Fazi B, Donnorso RP, Pearson AD, Hall AG, Redfern CP, Piacentini M. Lovat PE, et al. J Natl Cancer Inst. 2004 Sep 1;96(17):1288-99. doi: 10.1093/jnci/djh254. J Natl Cancer Inst. 2004. PMID: 15339967

The role of gangliosides in fenretinide-induced apoptosis of neuroblastoma.

Lovat PE, Corazzari M, Di Sano F, Piacentini M, Redfern CP. Lovat PE, et al. Cancer Lett. 2005 Oct 18;228(1-2):105-10. doi: 10.1016/j.canlet.2005.01.044. Cancer Lett. 2005. PMID: 15907365 Review.

Fenretinide activates a distinct apoptotic pathway.

Dmitrovsky E. Dmitrovsky E. J Natl Cancer Inst. 2004 Sep 1;96(17):1264-5. doi: 10.1093/jnci/djh268. J Natl Cancer Inst. 2004. PMID: 15339958 No abstract available.

Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells.

Lovat PE, Corazzari M, Goranov B, Piacentini M, Redfern CP. Lovat PE, et al. Ann N Y Acad Sci. 2004 Dec;1028:81-9. doi: 10.1196/annals.1322.009. Ann N Y Acad Sci. 2004. PMID: 15650234 Review.

GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.

Lovat PE, Oliverio S, Ranalli M, Corazzari M, Rodolfo C, Bernassola F, Aughton K, Maccarrone M, Hewson QD, Pearson AD, Melino G, Piacentini M, Redfern CP. Lovat PE, et al. Cancer Res. 2002 Sep 15;62(18):5158-67. Cancer Res. 2002. PMID: 12234979

Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma.

Lovat PE, Ranalli M, Corazzari M, Raffaghello L, Pearson AD, Ponzoni M, Piacentini M, Melino G, Redfern CP. Lovat PE, et al. J Cell Biochem. 2003 Jul 1;89(4):698-708. doi: 10.1002/jcb.10551. J Cell Biochem. 2003. PMID: 12858336

Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells.

Jiang L, Pan X, Chen Y, Wang K, Du Y, Zhang J. Jiang L, et al. Biochem Biophys Res Commun. 2011 Feb 11;405(2):314-8. doi: 10.1016/j.bbrc.2011.01.036. Epub 2011 Jan 13. Biochem Biophys Res Commun. 2011. PMID: 21237137

The NF-kappaB pathway mediates fenretinide-induced apoptosis in SH-SY5Y neuroblastoma cells.

Hewson QD, Lovat PE, Corazzari M, Catterall JB, Redfern CP. Hewson QD, et al. Apoptosis. 2005 May;10(3):493-8. doi: 10.1007/s10495-005-1878-z. Apoptosis. 2005. PMID: 15909111

N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.

Wang H, Maurer BJ, Reynolds CP, Cabot MC. Wang H, et al. Cancer Res. 2001 Jul 1;61(13):5102-5. Cancer Res. 2001. PMID: 11431347

Bak: a downstream mediator of fenretinide-induced apoptosis of SH-SY5Y neuroblastoma cells.

Lovat PE, Oliverio S, Corazzari M, Rodolfo C, Ranalli M, Goranov B, Melino G, Redfern CP, Piacentini M. Lovat PE, et al. Cancer Res. 2003 Nov 1;63(21):7310-3. Cancer Res. 2003. PMID: 14612528

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