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aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.

Suzuki A, Hirata M, Kamimura K, Maniwa R, Yamanaka T, Mizuno K, Kishikawa M, Hirose H, Amano Y, Izumi N, Miwa Y, Ohno S.

Curr Biol. 2004 Aug 24;14(16):1425-35.


Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.

Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S.

Curr Biol. 2003 Apr 29;13(9):734-43.


Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.

Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S.

J Cell Sci. 2009 May 15;122(Pt 10):1595-606. doi: 10.1242/jcs.043174.


Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.

Hurov JB, Watkins JL, Piwnica-Worms H.

Curr Biol. 2004 Apr 20;14(8):736-41.


aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization.

Suzuki A, Ishiyama C, Hashiba K, Shimizu M, Ebnet K, Ohno S.

J Cell Sci. 2002 Sep 15;115(Pt 18):3565-73.


Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation.

Hirose T, Izumi Y, Nagashima Y, Tamai-Nagai Y, Kurihara H, Sakai T, Suzuki Y, Yamanaka T, Suzuki A, Mizuno K, Ohno S.

J Cell Sci. 2002 Jun 15;115(Pt 12):2485-95.


PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.

Yamanaka T, Horikoshi Y, Suzuki A, Sugiyama Y, Kitamura K, Maniwa R, Nagai Y, Yamashita A, Hirose T, Ishikawa H, Ohno S.

Genes Cells. 2001 Aug;6(8):721-31.


Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.

Suzuki A, Yamanaka T, Hirose T, Manabe N, Mizuno K, Shimizu M, Akimoto K, Izumi Y, Ohnishi T, Ohno S.

J Cell Biol. 2001 Mar 19;152(6):1183-96.


aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation.

Iden S, Misselwitz S, Peddibhotla SS, Tuncay H, Rehder D, Gerke V, Robenek H, Suzuki A, Ebnet K.

J Cell Biol. 2012 Mar 5;196(5):623-39. doi: 10.1083/jcb.201104143.


KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.

Yoshihama Y, Sasaki K, Horikoshi Y, Suzuki A, Ohtsuka T, Hakuno F, Takahashi S, Ohno S, Chida K.

Curr Biol. 2011 Apr 26;21(8):705-11. doi: 10.1016/j.cub.2011.03.029.


Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity.

Chen YM, Wang QJ, Hu HS, Yu PC, Zhu J, Drewes G, Piwnica-Worms H, Luo ZG.

Proc Natl Acad Sci U S A. 2006 May 30;103(22):8534-9.


An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3.

Izumi Y, Hirose T, Tamai Y, Hirai S, Nagashima Y, Fujimoto T, Tabuse Y, Kemphues KJ, Ohno S.

J Cell Biol. 1998 Oct 5;143(1):95-106.


Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization.

Satohisa S, Chiba H, Osanai M, Ohno S, Kojima T, Saito T, Sawada N.

Exp Cell Res. 2005 Oct 15;310(1):66-78.


Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity.

Yamanaka T, Horikoshi Y, Izumi N, Suzuki A, Mizuno K, Ohno S.

J Cell Sci. 2006 May 15;119(Pt 10):2107-18.


Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells.

Benton R, St Johnston D.

Cell. 2003 Dec 12;115(6):691-704. Erratum in: Cell. 2004 Jan 9;116(1):139.


Intracellular polarity protein PAR-1 regulates extracellular laminin assembly by regulating the dystroglycan complex.

Masuda-Hirata M, Suzuki A, Amano Y, Yamashita K, Ide M, Yamanaka T, Sakai M, Imamura M, Ohno S.

Genes Cells. 2009 Jul;14(7):835-50. doi: 10.1111/j.1365-2443.2009.01315.x.


ASPP2 regulates epithelial cell polarity through the PAR complex.

Cong W, Hirose T, Harita Y, Yamashita A, Mizuno K, Hirano H, Ohno S.

Curr Biol. 2010 Aug 10;20(15):1408-14. doi: 10.1016/j.cub.2010.06.024.


The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity.

Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D.

J Cell Sci. 2003 Oct 1;116(Pt 19):3879-91.

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