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Items: 1 to 20 of 217

1.
5.

In vitro metabolism of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rat, monkey, and human liver microsomes and freshly isolated hepatocytes.

Uchiyama M, Koda H, Fischer T, Mueller J, Yamamura N, Oguchi M, Iwabuchi H, Okazaki O, Izumi T.

Drug Metab Dispos. 2011 Jul;39(7):1311-9. doi: 10.1124/dmd.111.038729. Epub 2011 Apr 21.

PMID:
21511943
6.

Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.

Reddy VB, Karanam BV, Gruber WL, Wallace MA, Vincent SH, Franklin RB, Baillie TA.

Chem Res Toxicol. 2005 May;18(5):880-8.

PMID:
15892582
7.

Identification of novel metabolic pathways of pioglitazone in hepatocytes: N-glucuronidation of thiazolidinedione ring and sequential ring-opening pathway.

Uchiyama M, Fischer T, Mueller J, Oguchi M, Yamamura N, Koda H, Iwabuchi H, Izumi T.

Drug Metab Dispos. 2010 Jun;38(6):946-56. doi: 10.1124/dmd.109.031583. Epub 2010 Feb 25.

PMID:
20185540
8.

Plasma stability-dependent circulation of acyl glucuronide metabolites in humans: how circulating metabolite profiles of muraglitazar and peliglitazar can lead to misleading risk assessment.

Zhang D, Raghavan N, Wang L, Xue Y, Obermeier M, Chen S, Tao S, Zhang H, Cheng PT, Li W, Ramanathan R, Yang Z, Humphreys WG.

Drug Metab Dispos. 2011 Jan;39(1):123-31. doi: 10.1124/dmd.110.035048. Epub 2010 Sep 28.

PMID:
20876787
9.

Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in humans.

Kochansky CJ, Rippley RK, Yan KX, Song H, Wallace MA, Dean D, Jones AN, Lasseter K, Schwartz J, Vincent SH, Franklin RB, Wagner J.

Drug Metab Dispos. 2006 Sep;34(9):1457-61. Epub 2006 Jun 13.

PMID:
16772365
10.
11.

Species differences in the elimination of a peroxisome proliferator-activated receptor agonist highlighted by oxidative metabolism of its acyl glucuronide.

Kochansky CJ, Xia YQ, Wang S, Cato B, Creighton M, Vincent SH, Franklin RB, Reed JR.

Drug Metab Dispos. 2005 Dec;33(12):1894-904. Epub 2005 Sep 23.

PMID:
16183782
12.

Metabolism of MK-0524, a prostaglandin D2 receptor 1 antagonist, in microsomes and hepatocytes from preclinical species and humans.

Dean BJ, Chang S, Silva Elipe MV, Xia YQ, Braun M, Soli E, Zhao Y, Franklin RB, Karanam B.

Drug Metab Dispos. 2007 Feb;35(2):283-92. Epub 2006 Nov 28.

PMID:
17132765
13.

Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes.

Szotáková B, Skálová L, Baliharová V, Dvorscáková M, Storkánová L, Sispera L, Wsól V.

J Pharm Pharmacol. 2004 Feb;56(2):205-12.

PMID:
15005879
14.

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA.

Chem Res Toxicol. 2001 Jan;14(1):62-70.

PMID:
11170509
15.
17.

In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes.

Agrawal AK, Hop CE, Pang J, Silva Elipe MV, Desai RC, Leung KH, Franklin RB.

J Pharm Biomed Anal. 2005 Feb 23;37(2):351-8.

PMID:
15708677
18.

Pharmacokinetics, metabolism, and disposition of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rats and monkeys.

Uchiyama M, Iwabuchi H, Tsuruta F, Abe K, Takahashi M, Koda H, Oguchi M, Okazaki O, Izumi T.

Drug Metab Dispos. 2011 Apr;39(4):653-66. doi: 10.1124/dmd.110.036194. Epub 2010 Dec 21.

PMID:
21177486
19.

In vitro hepatic metabolism of cediranib, a potent vascular endothelial growth factor tyrosine kinase inhibitor: interspecies comparison and human enzymology.

Schulz-Utermoehl T, Spear M, Pollard CR, Pattison C, Rollison H, Sarda S, Ward M, Bushby N, Jordan A, Harrison M.

Drug Metab Dispos. 2010 Oct;38(10):1688-97. doi: 10.1124/dmd.110.033159. Epub 2010 Jul 15.

PMID:
20634336
20.

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