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Hypoxia and defective apoptosis drive genomic instability and tumorigenesis.

Nelson DA, Tan TT, Rabson AB, Anderson D, Degenhardt K, White E.

Genes Dev. 2004 Sep 1;18(17):2095-107. Epub 2004 Aug 16.


BAX and BAK mediate p53-independent suppression of tumorigenesis.

Degenhardt K, Chen G, Lindsten T, White E.

Cancer Cell. 2002 Sep;2(3):193-203.


Bax and Bak independently promote cytochrome C release from mitochondria.

Degenhardt K, Sundararajan R, Lindsten T, Thompson C, White E.

J Biol Chem. 2002 Apr 19;277(16):14127-34. Epub 2002 Feb 8.


Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin.

Panaretakis T, Pokrovskaja K, Shoshan MC, Grandér D.

J Biol Chem. 2002 Nov 15;277(46):44317-26. Epub 2002 Aug 21.


Noxa induces apoptosis in oncogene-expressing cells through catch-and-release mechanism operating between Puma and Mcl-1.

Nakajima W, Tanaka N.

Biochem Biophys Res Commun. 2011 Oct 7;413(4):643-8. doi: 10.1016/j.bbrc.2011.09.036. Epub 2011 Sep 14.


Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC.

Science. 2007 Feb 9;315(5813):856-9.


Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins.

Callus BA, Moujallad DM, Silke J, Gerl R, Jabbour AM, Ekert PG, Vaux DL.

J Mol Biol. 2008 Dec 12;384(2):313-23. doi: 10.1016/j.jmb.2008.09.041. Epub 2008 Sep 25.


Nonredundant role of Bax and Bak in Bid-mediated apoptosis.

Cartron PF, Juin P, Oliver L, Martin S, Meflah K, Vallette FM.

Mol Cell Biol. 2003 Jul;23(13):4701-12.


BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak.

Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB.

Genes Dev. 2001 Jun 15;15(12):1481-6.


Apoptosis inhibitor as a suppressor of tumor progression: expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor.

Gurova KV, Kwek SS, Koman IE, Komarov AP, Kandel E, Nikiforov MA, Gudkov AV.

Cancer Biol Ther. 2002 Jan-Feb;1(1):39-44.


Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland.

Metcalfe AD, Gilmore A, Klinowska T, Oliver J, Valentijn AJ, Brown R, Ross A, MacGregor G, Hickman JA, Streuli CH.

J Cell Sci. 1999 Jun;112 ( Pt 11):1771-83.


Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.

Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.

Nat Cell Biol. 2006 Dec;8(12):1348-58. Epub 2006 Nov 19.


Extended survivability of prostate cancer cells in the absence of trophic factors: increased proliferation, evasion of apoptosis, and the role of apoptosis proteins.

Tang DG, Li L, Chopra DP, Porter AT.

Cancer Res. 1998 Aug 1;58(15):3466-79. Erratum in: Cancer Res 1998 Nov 15;58(22):5260.


Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions.

Finnegan NM, Curtin JF, Prevost G, Morgan B, Cotter TG.

Br J Cancer. 2001 Jul 6;85(1):115-21.


Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway.

Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, Schulze-Osthoff K, Daniel PT.

EMBO J. 2003 Jul 15;22(14):3580-90.

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