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Items: 1 to 20 of 71

1.

Crystallization and preliminary X-ray diffraction studies of 5-chlorolevulinate-modified bovine porphobilinogen synthase and the Pb(II)-complexed enzyme.

Carrell HL, Glusker JP, Shimoni L, Keefe LJ, Afshar C, Volin M, Jaffe EK.

Acta Crystallogr D Biol Crystallogr. 1996 Mar 1;52(Pt 2):419-21.

PMID:
15299718
2.

5-Chlorolevulinate modification of porphobilinogen synthase identifies a potential role for the catalytic zinc.

Jaffe EK, Abrams WR, Kaempfen HX, Harris KA Jr.

Biochemistry. 1992 Feb 25;31(7):2113-23.

PMID:
1346974
3.

Crystallization and preliminary X-ray diffraction studies of E. coli porphobilinogen synthase and its heavy-atom derivatives.

Shimoni-Livny L, Carrell HL, Wagner T, Kaufman Katz A, Afshar C, Mitchell LW, Volin M, Jaffe EK, Glusker JP.

Acta Crystallogr D Biol Crystallogr. 1998 May 1;54(Pt 3):438-40.

PMID:
9761921
4.
5.

Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase.

Mitchell LW, Volin M, Martins J, Jaffe EK.

J Biol Chem. 2001 Jan 12;276(2):1538-44.

6.

The molecular mechanism of lead inhibition of human porphobilinogen synthase.

Jaffe EK, Martins J, Li J, Kervinen J, Dunbrack RL Jr.

J Biol Chem. 2001 Jan 12;276(2):1531-7.

7.
8.

Porphobilinogen synthase from Escherichia coli is a Zn(II) metalloenzyme stimulated by Mg(II).

Mitchell LW, Jaffe EK.

Arch Biochem Biophys. 1993 Jan;300(1):169-77.

PMID:
8424649
9.

Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity.

Kervinen J, Jaffe EK, Stauffer F, Neier R, Wlodawer A, Zdanov A.

Biochemistry. 2001 Jul 27;40(28):8227-36.

PMID:
11444968
10.

Tracking the evolution of porphobilinogen synthase metal dependence in vitro.

Frère F, Reents H, Schubert WD, Heinz DW, Jahn D.

J Mol Biol. 2005 Feb 4;345(5):1059-70. Epub 2004 Dec 21.

PMID:
15644204
11.

An artificial gene for human porphobilinogen synthase allows comparison of an allelic variation implicated in susceptibility to lead poisoning.

Jaffe EK, Volin M, Bronson-Mullins CR, Dunbrack RL Jr, Kervinen J, Martins J, Quinlan JF Jr, Sazinsky MH, Steinhouse EM, Yeung AT.

J Biol Chem. 2000 Jan 28;275(4):2619-26.

12.

Probing of active site residues of the zinc enzyme 5-aminolevulinate dehydratase by spin and fluorescence labels.

Block C, Lohmann RD, Beyersmann D.

Biol Chem Hoppe Seyler. 1990 Dec;371(12):1145-52.

PMID:
1965291
13.

The porphobilinogen synthase catalyzed reaction mechanism.

Jaffe EK.

Bioorg Chem. 2004 Oct;32(5):316-25. Review.

PMID:
15381398
14.

Inhibition studies of porphobilinogen synthase from Escherichia coli differentiating between the two recognition sites.

Stauffer F, Zizzari E, Engeloch-Jarret C, Faurite JP, Bobálová J, Neier R.

Chembiochem. 2001 May 4;2(5):343-54.

PMID:
11828463
15.

A structural basis for half-of-the-sites metal binding revealed in Drosophila melanogaster porphobilinogen synthase.

Kundrat L, Martins J, Stith L, Dunbrack RL Jr, Jaffe EK.

J Biol Chem. 2003 Aug 15;278(33):31325-30. Epub 2003 Jun 6.

17.

The porphobilinogen synthase family of metalloenzymes.

Jaffe EK.

Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):115-28. Review.

PMID:
10666591
18.

Crystal structure of Toxoplasma gondii porphobilinogen synthase: insights on octameric structure and porphobilinogen formation.

Jaffe EK, Shanmugam D, Gardberg A, Dieterich S, Sankaran B, Stewart LJ, Myler PJ, Roos DS.

J Biol Chem. 2011 Apr 29;286(17):15298-307. doi: 10.1074/jbc.M111.226225. Epub 2011 Mar 7.

19.

Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins).

Tang L, Breinig S, Stith L, Mischel A, Tannir J, Kokona B, Fairman R, Jaffe EK.

J Biol Chem. 2006 Mar 10;281(10):6682-90. Epub 2005 Dec 23.

20.

The Remarkable Character of Porphobilinogen Synthase.

Jaffe EK.

Acc Chem Res. 2016 Nov 15;49(11):2509-2517. Epub 2016 Oct 26.

PMID:
27783504

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