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Chk1 is haploinsufficient for multiple functions critical to tumor suppression.

Lam MH, Liu Q, Elledge SJ, Rosen JM.

Cancer Cell. 2004 Jul;6(1):45-59.


Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ.

Genes Dev. 2000 Jun 15;14(12):1448-59.


ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage.

Sørensen CS, Syljuåsen RG, Lukas J, Bartek J.

Cell Cycle. 2004 Jul;3(7):941-5. Epub 2004 Jul 13.


Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling.

Jurvansuu J, Fragkos M, Ingemarsdotter C, Beard P.

J Mol Biol. 2007 Sep 14;372(2):397-406. Epub 2007 Jul 3.


The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.

Peddibhotla S, Lam MH, Gonzalez-Rimbau M, Rosen JM.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5159-64. doi: 10.1073/pnas.0806671106. Epub 2009 Mar 16.


Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.

Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ.

Science. 1997 Sep 5;277(5331):1497-501.


Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

Zhao H, Watkins JL, Piwnica-Worms H.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14795-800. Epub 2002 Oct 24.


LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms.

King C, Diaz HB, McNeely S, Barnard D, Dempsey J, Blosser W, Beckmann R, Barda D, Marshall MS.

Mol Cancer Ther. 2015 Sep;14(9):2004-13. doi: 10.1158/1535-7163.MCT-14-1037. Epub 2015 Jul 3.


SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW.

Genes Dev. 2003 Dec 15;17(24):3062-74. Epub 2003 Dec 17.


HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability.

Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD, Boulton SJ.

Nat Cell Biol. 2007 Apr;9(4):391-401. Epub 2007 Mar 25.


The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin.

Zhang Y, Qu D, Morris EJ, O'Hare MJ, Callaghan SM, Slack RS, Geller HM, Park DS.

J Neurosci. 2006 Aug 23;26(34):8819-28.


Role of checkpoint kinase 1 in preventing premature mitosis in response to gemcitabine.

Morgan MA, Parsels LA, Parsels JD, Mesiwala AK, Maybaum J, Lawrence TS.

Cancer Res. 2005 Aug 1;65(15):6835-42.


Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase.

Rainey MD, Black EJ, Zachos G, Gillespie DA.

Oncogene. 2008 Feb 7;27(7):896-906. Epub 2007 Aug 6.


Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.

Chen MS, Ryan CE, Piwnica-Worms H.

Mol Cell Biol. 2003 Nov;23(21):7488-97.


Chk1 is essential for tumor cell viability following activation of the replication checkpoint.

Cho SH, Toouli CD, Fujii GH, Crain C, Parry D.

Cell Cycle. 2005 Jan;4(1):131-9. Epub 2005 Jan 15.


A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation.

Xiao Z, Xue J, Sowin TJ, Rosenberg SH, Zhang H.

Oncogene. 2005 Feb 17;24(8):1403-11.


Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.

Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H.

J Biol Chem. 2003 Jun 13;278(24):21767-73. Epub 2003 Apr 3.

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