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Items: 1 to 20 of 129


Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni.

Gabrielsen M, Rohdich F, Eisenreich W, Gräwert T, Hecht S, Bacher A, Hunter WN.

Eur J Biochem. 2004 Jul;271(14):3028-35.


Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum.

Rohdich F, Eisenreich W, Wungsintaweekul J, Hecht S, Schuhr CA, Bacher A.

Eur J Biochem. 2001 Jun;268(11):3190-7.


Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis.

Gabrielsen M, Bond CS, Hallyburton I, Hecht S, Bacher A, Eisenreich W, Rohdich F, Hunter WN.

J Biol Chem. 2004 Dec 10;279(50):52753-61. Epub 2004 Oct 2.


Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate.

Herz S, Wungsintaweekul J, Schuhr CA, Hecht S, Luttgen H, Sagner S, Fellermeier M, Eisenreich W, Zenk MH, Bacher A, Rohdich F.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2486-90.


Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF.

Narayanasamy P, Eoh H, Brennan PJ, Crick DC.

Chem Biol. 2010 Feb 26;17(2):117-22. doi: 10.1016/j.chembiol.2010.01.013.


2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity.

Bitok JK, Meyers CF.

ACS Chem Biol. 2012 Oct 19;7(10):1702-10. doi: 10.1021/cb300243w. Epub 2012 Aug 6.


Biosynthesis of terpenoids: efficient multistep biotransformation procedures affording isotope-labeled 2C-methyl-D-erythritol 4-phosphate using recombinant 2C-methyl-D-erythritol 4-phosphate synthase.

Hecht S, Wungsintaweekul J, Rohdich F, Kis K, Radykewicz T, Schuhr CA, Eisenreich W, Richter G, Bacher A.

J Org Chem. 2001 Nov 16;66(23):7770-5.


Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment.

O'Rourke PE, Kalinowska-Tłuścik J, Fyfe PK, Dawson A, Hunter WN.

BMC Struct Biol. 2014 Jan 10;14:1. doi: 10.1186/1472-6807-14-1.


Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids.

Steinbacher S, Kaiser J, Wungsintaweekul J, Hecht S, Eisenreich W, Gerhardt S, Bacher A, Rohdich F.

J Mol Biol. 2002 Feb 8;316(1):79-88.


Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum.

Singh VK, Ghosh I.

FEBS Lett. 2013 Sep 2;587(17):2806-17. doi: 10.1016/j.febslet.2013.06.024. Epub 2013 Jun 28.


Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants.

Fellermeier M, Raschke M, Sagner S, Wungsintaweekul J, Schuhr CA, Hecht S, Kis K, Radykewicz T, Adam P, Rohdich F, Eisenreich W, Bacher A, Arigoni D, Zenk MH.

Eur J Biochem. 2001 Dec;268(23):6302-10.


Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods.

Illarionova V, Kaiser J, Ostrozhenkova E, Bacher A, Fischer M, Eisenreich W, Rohdich F.

J Org Chem. 2006 Nov 10;71(23):8824-34.


Biosynthesis of isoprenoids: studies on the mechanism of 2C-methyl-D-erythritol-4-phosphate synthase.

Lauw S, Illarionova V, Bacher A, Rohdich F, Eisenreich W.

FEBS J. 2008 Aug;275(16):4060-73. doi: 10.1111/j.1742-4658.2008.06547.x. Epub 2008 Jul 4.


Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens.

Eoh H, Narayanasamy P, Brown AC, Parish T, Brennan PJ, Crick DC.

Chem Biol. 2009 Dec 24;16(12):1230-9. doi: 10.1016/j.chembiol.2009.10.014.


Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein.

Hecht S, Eisenreich W, Adam P, Amslinger S, Kis K, Bacher A, Arigoni D, Rohdich F.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14837-42.

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