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Items: 1 to 20 of 112

1.

Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.

Loewer A, Soba P, Beyreuther K, Paro R, Merdes G.

EMBO Rep. 2004 Apr;5(4):405-11.

2.

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.

Chung HM, Struhl G.

Nat Cell Biol. 2001 Dec;3(12):1129-32.

PMID:
11781576
3.

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

Ye Y, Lukinova N, Fortini ME.

Nature. 1999 Apr 8;398(6727):525-9.

PMID:
10206647
4.

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.

Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.

J Neurochem. 2006 Feb;96(3):732-42. Epub 2006 Jan 9.

5.

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila.

Struhl G, Greenwald I.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):229-34.

6.
7.

Identifying genes that interact with Drosophila presenilin and amyloid precursor protein.

van de Hoef DL, Hughes J, Livne-Bar I, Garza D, Konsolaki M, Boulianne GL.

Genesis. 2009 Apr;47(4):246-60. doi: 10.1002/dvg.20485.

PMID:
19241393
8.
9.

Notch and presenilin: a proteolytic mechanism emerges.

Fortini ME.

Curr Opin Cell Biol. 2001 Oct;13(5):627-34. Review. Erratum in: Curr Opin Cell Biol 2001 Dec;13(6):785.

PMID:
11544033
10.

Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.

Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J.

Traffic. 2006 Mar;7(3):354-64.

11.

Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.

Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.

Neurobiol Dis. 2007 Feb;25(2):291-6. Epub 2006 Oct 27.

PMID:
17071095
14.

Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila.

Merdes G, Soba P, Loewer A, Bilic MV, Beyreuther K, Paro R.

EMBO J. 2004 Oct 13;23(20):4082-95. Epub 2004 Sep 23.

15.

Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells.

Suga K, Saito A, Tomiyama T, Mori H, Akagawa K.

J Neurochem. 2005 Jul;94(2):425-39.

16.

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.

Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O.

J Biol Chem. 2005 Jul 22;280(29):27303-9. Epub 2005 May 25.

17.

In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.

Hoke DE, Tan JL, Ilaya NT, Culvenor JG, Smith SJ, White AR, Masters CL, Evin GM.

FEBS J. 2005 Nov;272(21):5544-57.

18.

Presenilin is required for activity and nuclear access of Notch in Drosophila.

Struhl G, Greenwald I.

Nature. 1999 Apr 8;398(6727):522-5.

PMID:
10206646
19.

The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.

Laudon H, Winblad B, Näslund J.

Physiol Behav. 2007 Sep 10;92(1-2):115-20. Epub 2007 May 21. Review.

PMID:
17588625
20.

Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein.

Olry A, Chastagner P, Israël A, Brou C.

J Biol Chem. 2005 Aug 5;280(31):28564-71. Epub 2005 Jun 15.

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