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Items: 1 to 20 of 122

1.

Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity.

Dutschman GE, Grill SP, Gullen EA, Haraguchi K, Takeda S, Tanaka H, Baba M, Cheng YC.

Antimicrob Agents Chemother. 2004 May;48(5):1640-6.

2.

Comparison of the phosphorylation of 4'-ethynyl 2',3'-dihydro-3'-deoxythymidine with that of other anti-human immunodeficiency virus thymidine analogs.

Hsu CH, Hu R, Dutschman GE, Yang G, Krishnan P, Tanaka H, Baba M, Cheng YC.

Antimicrob Agents Chemother. 2007 May;51(5):1687-93. Epub 2007 Mar 12.

3.
4.

Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.

Paintsil E, Dutschman GE, Hu R, Grill SP, Lam W, Baba M, Tanaka H, Cheng YC.

Antimicrob Agents Chemother. 2007 Nov;51(11):3870-9. Epub 2007 Aug 27.

5.
6.

Synthesis of a highly active new anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine.

Haraguchi K, Takeda S, Tanaka H, Nitanda T, Baba M, Dutschman GE, Cheng YC.

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3775-7.

PMID:
14552777
7.

Myristoylated derivatives of 2',3'-didehydro-2',3'-dideoxythymidine (stavudine) bi-functional prodrugs with potent anti-HIV-1 activity and low cytotoxicity.

Singh RK, Miazga A, DÄ…browska A, Lipniacki A, Piasek A, Kulikowski T, Shugar D.

Antivir Chem Chemother. 2014 Dec 16;23(6):231-5. doi: 10.3851/IMP2679.

PMID:
23985753
8.

Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes.

Drake RR, McMasters R, Krisa S, Hume SD, Rechtin TM, Saylors RL, Chiang Y, Govindarajan R, Munshi NC.

Antiviral Res. 1997 Aug;35(3):177-85.

PMID:
9298757
9.

Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP.

Balzarini J, Aquaro S, Knispel T, Rampazzo C, Bianchi V, Perno CF, De Clercq E, Meier C.

Mol Pharmacol. 2000 Nov;58(5):928-35.

10.
11.

Relative mutagenic potencies of several nucleoside analogs, alone or in drug pairs, at the HPRT and TK loci of human TK6 lymphoblastoid cells.

Carter MM, Torres SM, Cook DL Jr, McCash CL, Yu M, Walker VE, Walker DM.

Environ Mol Mutagen. 2007 Apr-May;48(3-4):239-47.

PMID:
17358029
13.

Anti-HIV antiviral activity of stavudine in a thymidine kinase-deficient cellular line.

Turriziani O, Simeoni E, Dianzani F, Antonelli G.

Antivir Ther. 1998;3(3):191-4.

PMID:
10682138
14.

Synthesis and biological evaluation of fatty acyl ester derivatives of 2',3'-didehydro-2',3'-dideoxythymidine.

Agarwal HK, Loethan K, Mandal D, Doncel GF, Parang K.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):1917-21. doi: 10.1016/j.bmcl.2011.02.070. Epub 2011 Feb 18.

PMID:
21382714
15.

Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.

Yang G, Wang J, Cheng Y, Dutschman GE, Tanaka H, Baba M, Cheng YC.

Antimicrob Agents Chemother. 2008 Jun;52(6):2035-42. doi: 10.1128/AAC.00083-08. Epub 2008 Apr 7.

16.

A new approach to the synthesis of 4'-carbon-substituted nucleosides: development of a highly active anti-HIV agent 2', 3'-didehydro-3'-deoxy-4'-ethynylthymidine.

Haraguchi K, Takeda S, Sumino M, Tanaka H, Dutschman GE, Cheng YC, Nitanda T, Baba M.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):343-7.

PMID:
16247949
17.

Retention of metabolites of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel anti-human immunodeficiency virus type 1 thymidine analog, in cells.

Wang X, Tanaka H, Baba M, Cheng YC.

Antimicrob Agents Chemother. 2009 Aug;53(8):3317-24. doi: 10.1128/AAC.00302-09. Epub 2009 May 26.

18.

Selection of a T-cell line resistant to stavudine and zidovudine by prolonged treatment with stavudine.

Turriziani O, Scagnolari C, Bambacioni F, Bellomi F, Focher F, Gentile M, Antonelli G.

Antivir Ther. 2002 Jun;7(2):105-11.

PMID:
12212922
19.

Synthesis, and in vitro enzymatic and antiviral evaluation of d4T polyphosphate derivatives as chain terminators.

Yang S, Pannecouque C, Herdewijn P.

Chem Biodivers. 2012 Oct;9(10):2186-94. doi: 10.1002/cbdv.201200250.

PMID:
23081918
20.

Comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virus.

Mansuri MM, Hitchcock MJ, Buroker RA, Bregman CL, Ghazzouli I, Desiderio JV, Starrett JE, Sterzycki RZ, Martin JC.

Antimicrob Agents Chemother. 1990 Apr;34(4):637-41.

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