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Items: 1 to 20 of 156

1.

Kava does not display metabolic toxicity in a homogeneous cellular assay.

Zou L, Harkey MR, Henderson GL, Dike LE.

Planta Med. 2004 Apr;70(4):289-92.

PMID:
15095141
2.
3.

Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro.

Weiss J, Sauer A, Frank A, Unger M.

Drug Metab Dispos. 2005 Nov;33(11):1580-3. Epub 2005 Jul 28.

4.

Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).

Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ.

Planta Med. 2002 Dec;68(12):1055-8.

PMID:
12494328
5.

Inhibition of human cytochrome P450 activities by kava extract and kavalactones.

Mathews JM, Etheridge AS, Black SR.

Drug Metab Dispos. 2002 Nov;30(11):1153-7.

6.

Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.

Li Y, Mei H, Wu Q, Zhang S, Fang JL, Shi L, Guo L.

Toxicol Sci. 2011 Dec;124(2):388-99. doi: 10.1093/toxsci/kfr235. Epub 2011 Sep 9.

PMID:
21908763
7.

Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum).

Hashimoto T, Suganuma M, Fujiki H, Yamada M, Kohno T, Asakawa Y.

Phytomedicine. 2003 May;10(4):309-17.

PMID:
12809361
8.

Kavalactones fail to inhibit alcohol dehydrogenase in vitro.

Anke J, Fu S, Ramzan I.

Phytomedicine. 2006 Feb;13(3):192-5. Epub 2005 Jun 28.

PMID:
16428028
9.

Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.).

Anke J, Ramzan I.

J Ethnopharmacol. 2004 Aug;93(2-3):153-60. Review.

PMID:
15234747
10.

Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s.

Styles JA, Davies A, Lim CK, De Matteis F, Stanley LA, White IN, Yuan ZX, Smith LL.

Carcinogenesis. 1994 Jan;15(1):5-9.

PMID:
8293548
11.

Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro.

Mathews JM, Etheridge AS, Valentine JL, Black SR, Coleman DP, Patel P, So J, Burka LT.

Drug Metab Dispos. 2005 Oct;33(10):1555-63. Epub 2005 Jul 20.

12.

Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava).

Uebelhack R, Franke L, Schewe HJ.

Pharmacopsychiatry. 1998 Sep;31(5):187-92.

PMID:
9832350
13.

Melanogenesis stimulation in murine B16 melanoma cells by Kava (Piper methysticum) rhizome extract and kavalactones.

Matsuda H, Hirata N, Kawaguchi Y, Naruto S, Takata T, Oyama M, Iinuma M, Kubo M.

Biol Pharm Bull. 2006 Apr;29(4):834-7.

15.

Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro.

Tang J, Dunlop RA, Rowe A, Rodgers KJ, Ramzan I.

Phytother Res. 2011 Mar;25(3):417-23. doi: 10.1002/ptr.3283. Epub 2010 Aug 23.

PMID:
20734326
16.

Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells.

Whittaker P, Clarke JJ, San RH, Betz JM, Seifried HE, de Jager LS, Dunkel VC.

Food Chem Toxicol. 2008 Jan;46(1):168-74. Epub 2007 Jul 31.

PMID:
17822821
17.

Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm.

Smith KK, Dharmaratne HR, Feltenstein MW, Broom SL, Roach JT, Nanayakkara NP, Khan IA, Sufka KJ.

Psychopharmacology (Berl). 2001 Apr;155(1):86-90.

PMID:
11374340
18.

Interaction of various Piper methysticum cultivars with CNS receptors in vitro.

Dinh LD, Simmen U, Bueter KB, Bueter B, Lundstrom K, Schaffner W.

Planta Med. 2001 Jun;67(4):306-11.

PMID:
11458444
19.

Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure.

Feltenstein MW, Lambdin LC, Ganzera M, Ranjith H, Dharmaratne W, Nanayakkara NP, Khan IA, Sufka KJ.

Phytother Res. 2003 Mar;17(3):210-6.

PMID:
12672148
20.

Superheated water chromatography-nuclear magnetic resonance spectroscopy of kava lactones.

Chienthavorn O, Smith RM, Wilson ID, Wright B, Lenz EM.

Phytochem Anal. 2005 May-Jun;16(3):217-21.

PMID:
15997856

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