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CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products.

DeLozier TC, Tsao CC, Coulter SJ, Foley J, Bradbury JA, Zeldin DC, Goldstein JA.

J Pharmacol Exp Ther. 2004 Sep;310(3):845-54. Epub 2004 Apr 14.


Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid.

Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA.

Arch Biochem Biophys. 1998 Sep 1;357(1):45-57.


Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.

Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC.

Mol Pharmacol. 2004 May;65(5):1148-58.


Identification and localization of five CYP2Cs in murine extrahepatic tissues and their metabolism of arachidonic acid to regio- and stereoselective products.

Tsao CC, Coulter SJ, Chien A, Luo G, Clayton NP, Maronpot R, Goldstein JA, Zeldin DC.

J Pharmacol Exp Ther. 2001 Oct;299(1):39-47.


CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.

Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.

Mol Pharmacol. 2000 Aug;58(2):279-87.


Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney.

Zhang MZ, Wang Y, Yao B, Gewin L, Wei S, Capdevila JH, Harris RC.

Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1680-6. doi: 10.1152/ajprenal.00409.2013. Epub 2013 Oct 23.


Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect.

Wang WH, Zhang C, Lin DH, Wang L, Graves JP, Zeldin DC, Capdevila JH.

Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F453-60. doi: 10.1152/ajprenal.00123.2014. Epub 2014 Jun 25.


Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome P450 highly expressed in kidney.

Ma J, Qu W, Scarborough PE, Tomer KB, Moomaw CR, Maronpot R, Davis LS, Breyer MD, Zeldin DC.

J Biol Chem. 1999 Jun 18;274(25):17777-88.


Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns.

Oleksiak MF, Wu S, Parker C, Karchner SI, Stegeman JJ, Zeldin DC.

J Biol Chem. 2000 Jan 28;275(4):2312-21.


Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase.

Imaoka S, Wedlund PJ, Ogawa H, Kimura S, Gonzalez FJ, Kim HY.

J Pharmacol Exp Ther. 1993 Nov;267(2):1012-6.


Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes.

Wu S, Chen W, Murphy E, Gabel S, Tomer KB, Foley J, Steenbergen C, Falck JR, Moomaw CR, Zeldin DC.

J Biol Chem. 1997 May 9;272(19):12551-9.


Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism.

Theken KN, Deng Y, Kannon MA, Miller TM, Poloyac SM, Lee CR.

Drug Metab Dispos. 2011 Jan;39(1):22-9. doi: 10.1124/dmd.110.035287. Epub 2010 Oct 14.


Cyp2c44 epoxygenase is essential for preventing the renal sodium absorption during increasing dietary potassium intake.

Sun P, Antoun J, Lin DH, Yue P, Gotlinger KH, Capdevila J, Wang WH.

Hypertension. 2012 Feb;59(2):339-47. doi: 10.1161/HYPERTENSIONAHA.111.178475. Epub 2011 Dec 19.


Characterization of the Tissue Distribution of the Mouse Cyp2c Subfamily by Quantitative PCR Analysis.

Graves JP, Gruzdev A, Bradbury JA, DeGraff LM, Edin ML, Zeldin DC.

Drug Metab Dispos. 2017 Jul;45(7):807-816. doi: 10.1124/dmd.117.075697. Epub 2017 Apr 27.


Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension.

Capdevila J, Wang W.

Curr Opin Nephrol Hypertens. 2013 Mar;22(2):163-9. doi: 10.1097/MNH.0b013e32835d911e. Review.


Arachidonic acid metabolism in the marine fish Stenotomus chrysops (Scup) and the effects of cytochrome P450 1A inducers.

Schlezinger JJ, Parker C, Zeldin DC, Stegeman JJ.

Arch Biochem Biophys. 1998 May 15;353(2):265-75.


CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone.

Uno Y, Fujino H, Kito G, Kamataki T, Nagata R.

Mol Pharmacol. 2006 Aug;70(2):477-86. Epub 2006 Apr 28.


Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.

Zeldin DC, DuBois RN, Falck JR, Capdevila JH.

Arch Biochem Biophys. 1995 Sep 10;322(1):76-86.


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