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Items: 1 to 20 of 133

1.

Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans.

Walters DG, Young PJ, Agus C, Knize MG, Boobis AR, Gooderham NJ, Lake BG.

Carcinogenesis. 2004 Sep;25(9):1659-69. Epub 2004 Apr 8.

2.

Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man.

Murray S, Lake BG, Gray S, Edwards AJ, Springall C, Bowey EA, Williamson G, Boobis AR, Gooderham NJ.

Carcinogenesis. 2001 Sep;22(9):1413-20.

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A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine.

Gu D, McNaughton L, Lemaster D, Lake BG, Gooderham NJ, Kadlubar FF, Turesky RJ.

Chem Res Toxicol. 2010 Apr 19;23(4):788-801. doi: 10.1021/tx900436m.

6.

Apiaceous vegetable consumption decreases PhIP-induced DNA adducts and increases methylated PhIP metabolites in the urine metabolome in rats.

Kim JK, Gallaher DD, Chen C, Yao D, Trudo SP.

J Nutr. 2015 Mar;145(3):442-51. doi: 10.3945/jn.114.202622. Epub 2014 Dec 24.

7.

The identification of [2-(14)C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans.

Malfatti MA, Kulp KS, Knize MG, Davis C, Massengill JP, Williams S, Nowell S, MacLeod S, Dingley KH, Turteltaub KW, Lang NP, Felton JS.

Carcinogenesis. 1999 Apr;20(4):705-13.

8.

The urinary metabolite profile of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is predictive of colon DNA adducts after a low-dose exposure in humans.

Malfatti MA, Dingley KH, Nowell-Kadlubar S, Ubick EA, Mulakken N, Nelson D, Lang NP, Felton JS, Turteltaub KW.

Cancer Res. 2006 Nov 1;66(21):10541-7.

9.

Metabolites of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) in human urine after consumption of charbroiled or fried beef.

Strickland PT, Qian Z, Friesen MD, Rothman N, Sinha R.

Mutat Res. 2002 Sep 30;506-507:163-73. Review.

PMID:
12351156
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12.

Metabolism of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by lactating Fischer 344 rats and their nursing pups.

Davis CD, Ghoshal A, Schut HA, Snyderwine EG.

J Natl Cancer Inst. 1994 Jul 20;86(14):1065-70.

PMID:
8021955
13.

Biomonitoring of dietary heterocyclic amines and metabolites in urine by liquid phase microextraction: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a possible biomarker of exposure to dietary PhIP.

Busquets R, Frandsen H, Jönsson JÅ, Puignou L, Galceran MT, Skog K.

Chem Res Toxicol. 2013 Feb 18;26(2):233-40. doi: 10.1021/tx3003966. Epub 2013 Jan 15.

PMID:
23276304
15.

Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2.

Turesky RJ, Guengerich FP, Guillouzo A, Langouët S.

Mutat Res. 2002 Sep 30;506-507:187-95.

PMID:
12351158
16.

Intestinal bacteria metabolize the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine following consumption of a single cooked chicken meal in humans.

Vanhaecke L, Knize MG, Noppe H, De Brabander H, Verstraete W, Van de Wiele T.

Food Chem Toxicol. 2008 Jan;46(1):140-8. Epub 2007 Jul 21.

PMID:
17766021
17.

Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues.

Kaderlik KR, Minchin RF, Mulder GJ, Ilett KF, Daugaard-Jenson M, Teitel CH, Kadlubar FF.

Carcinogenesis. 1994 Aug;15(8):1703-9.

PMID:
8055652
18.

Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice.

Buonarati MH, Roper M, Morris CJ, Happe JA, Knize MG, Felton JS.

Carcinogenesis. 1992 Apr;13(4):621-7.

PMID:
1576715
19.

The effects of coffee on enzymes involved in metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats.

Turesky RJ, Richoz J, Constable A, Curtis KD, Dingley KH, Turteltaub KW.

Chem Biol Interact. 2003 Jun 15;145(3):251-65.

PMID:
12732453
20.

UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver.

Girard H, Thibaudeau J, Court MH, Fortier LC, Villeneuve L, Caron P, Hao Q, von Moltke LL, Greenblatt DJ, Guillemette C.

Hepatology. 2005 Aug;42(2):448-57.

PMID:
15986396
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