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Items: 1 to 20 of 110

1.

Phosphatases as small-molecule targets: inhibiting the endogenous inhibitors of kinases.

Schmid AC, Woscholski R.

Biochem Soc Trans. 2004 Apr;32(Pt 2):348-9. Review.

PMID:
15046606
2.
3.

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.

Lu Y, Yu Q, Liu JH, Zhang J, Wang H, Koul D, McMurray JS, Fang X, Yung WK, Siminovitch KA, Mills GB.

J Biol Chem. 2003 Oct 10;278(41):40057-66. Epub 2003 Jul 17.

4.

PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.

Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A.

J Biol Chem. 2005 Jun 10;280(23):22523-9. Epub 2005 Apr 11.

6.

Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.

Ono H, Katagiri H, Funaki M, Anai M, Inukai K, Fukushima Y, Sakoda H, Ogihara T, Onishi Y, Fujishiro M, Kikuchi M, Oka Y, Asano T.

Mol Endocrinol. 2001 Aug;15(8):1411-22.

PMID:
11463863
7.

Bisperoxovanadium compounds are potent PTEN inhibitors.

Schmid AC, Byrne RD, Vilar R, Woscholski R.

FEBS Lett. 2004 May 21;566(1-3):35-8.

8.

The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.

Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA.

Oncogene. 2004 Nov 11;23(53):8571-80. Erratum in: Oncogene. 2005 Jun 16;24(26)4320.

PMID:
15467756
9.

Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.

St-Germain ME, Gagnon V, Mathieu I, Parent S, Asselin E.

Int J Oncol. 2004 May;24(5):1311-24.

PMID:
15067356
10.

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.

Leslie NR, Bennett D, Gray A, Pass I, Hoang-Xuan K, Downes CP.

Biochem J. 2001 Jul 15;357(Pt 2):427-35.

11.

Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.

Downes CP, Bennett D, McConnachie G, Leslie NR, Pass I, MacPhee C, Patel L, Gray A.

Biochem Soc Trans. 2001 Nov;29(Pt 6):846-51. Review.

PMID:
11709086
12.

PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease.

Wishart MJ, Dixon JE.

Trends Cell Biol. 2002 Dec;12(12):579-85. Review.

PMID:
12495846
13.

PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.

Radu A, Neubauer V, Akagi T, Hanafusa H, Georgescu MM.

Mol Cell Biol. 2003 Sep;23(17):6139-49.

14.

Pten signaling in gliomas.

Knobbe CB, Merlo A, Reifenberger G.

Neuro Oncol. 2002 Jul;4(3):196-211. Review.

15.

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling.

Vazquez F, Sellers WR.

Biochim Biophys Acta. 2000 Feb 14;1470(1):M21-35. Review. No abstract available.

PMID:
10656987
17.

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4640-5. Epub 2001 Apr 3.

18.

PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway.

Kim S, Domon-Dell C, Wang Q, Chung DH, Di Cristofano A, Pandolfi PP, Freund JN, Evers BM.

Gastroenterology. 2002 Oct;123(4):1163-78.

PMID:
12360479
19.

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.

Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15587-91.

20.

Abnormal PTEN expression in portal hypertensive gastric mucosa: a key to impaired PI 3-kinase/Akt activation and delayed injury healing?

Tsugawa K, Jones MK, Akahoshi T, Moon WS, Maehara Y, Hashizume M, Sarfeh IJ, Tarnawski AS.

FASEB J. 2003 Dec;17(15):2316-8. Epub 2003 Oct 2.

PMID:
14525948

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