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Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications.

Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G.

Cancer Res. 2004 Feb 15;64(4):1475-82.


UVC inhibits HIF-1alpha protein translation by a DNA damage- and topoisomerase I-independent pathway.

Rapisarda A, Melillo G.

Oncogene. 2007 Oct 18;26(48):6875-84. Epub 2007 May 14.


Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.

Puppo M, Battaglia F, Ottaviano C, Delfino S, Ribatti D, Varesio L, Bosco MC.

Mol Cancer Ther. 2008 Jul;7(7):1974-84. doi: 10.1158/1535-7163.MCT-07-2059.


HIF-1alpha modulation by topoisomerase inhibitors in non-small cell lung cancer cell lines.

Choi YJ, Rho JK, Lee SJ, Jang WS, Lee SS, Kim CH, Lee JC.

J Cancer Res Clin Oncol. 2009 Aug;135(8):1047-53. doi: 10.1007/s00432-009-0543-2. Epub 2009 Jan 15.


Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts.

Rapisarda A, Zalek J, Hollingshead M, Braunschweig T, Uranchimeg B, Bonomi CA, Borgel SD, Carter JP, Hewitt SM, Shoemaker RH, Melillo G.

Cancer Res. 2004 Oct 1;64(19):6845-8.


YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.

Sun HL, Liu YN, Huang YT, Pan SL, Huang DY, Guh JH, Lee FY, Kuo SC, Teng CM.

Oncogene. 2007 Jun 7;26(27):3941-51. Epub 2007 Jan 8.


Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221.

Creighton-Gutteridge M, Cardellina JH 2nd, Stephen AG, Rapisarda A, Uranchimeg B, Hite K, Denny WA, Shoemaker RH, Melillo G.

Clin Cancer Res. 2007 Feb 1;13(3):1010-8.


Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.

Jin HO, An S, Lee HC, Woo SH, Seo SK, Choe TB, Yoo DH, Lee SB, Um HD, Lee SJ, Park MJ, Kim JI, Hong SI, Rhee CH, Park IC.

Cell Signal. 2007 Jul;19(7):1393-403. Epub 2007 Jan 20.


Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents.

Lou JJ, Chua YL, Chew EH, Gao J, Bushell M, Hagen T.

PLoS One. 2010 May 7;5(5):e10522. doi: 10.1371/journal.pone.0010522.


Heat induction of the unphosphorylated form of hypoxia-inducible factor-1alpha is dependent on heat shock protein-90 activity.

Katschinski DM, Le L, Heinrich D, Wagner KF, Hofer T, Schindler SG, Wenger RH.

J Biol Chem. 2002 Mar 15;277(11):9262-7. Epub 2002 Jan 4.


Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7.

Cho S, Choi YJ, Kim JM, Jeong ST, Kim JH, Kim SH, Ryu SE.

FEBS Lett. 2001 Jun 1;498(1):62-6.


The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors.

Harada H, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M.

J Biol Chem. 2009 Feb 20;284(8):5332-42. doi: 10.1074/jbc.M806653200. Epub 2008 Dec 19.


AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells.

Hwang JT, Lee M, Jung SN, Lee HJ, Kang I, Kim SS, Ha J.

Carcinogenesis. 2004 Dec;25(12):2497-507. Epub 2004 Aug 5.


Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.

Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Simioni C, Leung E, Maclennan S, Baraldi PG, Borea PA.

Mol Pharmacol. 2007 Aug;72(2):395-406. Epub 2007 May 8.


Mitoxantrone inhibits HIF-1α expression in a topoisomerase II-independent pathway.

Toh YM, Li TK.

Clin Cancer Res. 2011 Aug 1;17(15):5026-37. doi: 10.1158/1078-0432.CCR-11-0235. Epub 2011 Jun 8.

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