Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 72

1.

PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion.

Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K.

J Biol Chem. 2004 Apr 16;279(16):16441-51. Epub 2004 Feb 3.

2.

PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion.

Liu X, Hu Y, Hao C, Rempel SA, Ye K.

Oncogene. 2007 Jul 26;26(34):4918-27. Epub 2007 Feb 12.

PMID:
17297440
3.

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.

Ahn JY, Hu Y, Kroll TG, Allard P, Ye K.

Proc Natl Acad Sci U S A. 2004 May 4;101(18):6993-8. Epub 2004 Apr 26.

4.

PIKE GTPase signaling and function.

Ahn JY, Ye K.

Int J Biol Sci. 2005;1(2):44-50. Epub 2005 Apr 1. Review.

5.

M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A.

Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G.

J Virol. 2007 Mar;81(5):2340-8. Epub 2006 Dec 6.

6.
7.

PIKE GTPase: a novel mediator of phosphoinositide signaling.

Ye K, Snyder SH.

J Cell Sci. 2004 Jan 15;117(Pt 2):155-61. Review.

8.

Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion.

Liu R, Tian B, Gearing M, Hunter S, Ye K, Mao Z.

Proc Natl Acad Sci U S A. 2008 May 27;105(21):7570-5. doi: 10.1073/pnas.0712306105. Epub 2008 May 16.

9.

Phosphoinositide-3-Kinase Enhancers, PIKEs: Their Biological Functions and Roles in Cancer.

Jia W, Feng YI, Sanders AJ, Davies EL, Jiang WG.

Anticancer Res. 2016 Mar;36(3):1103-9. Review.

PMID:
26977005
10.

PIKE/nuclear PI 3-kinase signaling in preventing programmed cell death.

Ye K.

J Cell Biochem. 2005 Oct 15;96(3):463-72. Review.

PMID:
16088938
11.

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S.

Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11211-6.

12.

PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells.

Xie Z, Jiang Y, Liao EY, Chen Y, Pennypacker SD, Peng J, Chang SM.

Oncogene. 2012 Dec 6;31(49):5090-8. doi: 10.1038/onc.2012.10. Epub 2012 Feb 20.

PMID:
22349826
13.

Protein kinase B/akt and rab5 mediate Ras activation of endocytosis.

Barbieri MA, Kohn AD, Roth RA, Stahl PD.

J Biol Chem. 1998 Jul 31;273(31):19367-70.

14.

p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes.

Genot E, Reif K, Beach S, Kramer I, Cantrell D.

Oncogene. 1998 Oct 1;17(13):1731-8.

15.

Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner.

He K, Jang SW, Joshi J, Yoo MH, Ye K.

Mol Biol Cell. 2011 Jun 1;22(11):1943-54. doi: 10.1091/mbc.E10-11-0923. Epub 2011 Apr 1.

16.

Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production.

Kim D, Kim S, Koh H, Yoon SO, Chung AS, Cho KS, Chung J.

FASEB J. 2001 Sep;15(11):1953-62.

PMID:
11532975
17.

Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity.

Zhang S, Qi Q, Chan CB, Zhou W, Chen J, Luo HR, Appin C, Brat DJ, Ye K.

Cell Death Differ. 2016 Jan;23(1):52-63. doi: 10.1038/cdd.2015.66. Epub 2015 May 22.

18.
19.

Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer?

Chan CB, Ye K.

Rev Neurosci. 2012 Jan 26;23(2):153-61. doi: 10.1515/revneuro-2011-0066. Review.

20.

Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival.

Osada M, Tolkacheva T, Li W, Chan TO, Tsichlis PN, Saez R, Kimmelman AC, Chan AM.

Mol Cell Biol. 1999 Sep;19(9):6333-44.

Supplemental Content

Support Center