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Items: 1 to 20 of 215

1.

Total synthesis and antitubulin activity of c10 analogues of cryptophycin-24.

Buck SB, Huff JK, Himes RH, Georg GI.

J Med Chem. 2004 Jan 29;47(3):696-702.

PMID:
14736249
2.

Total synthesis and anti-tubulin activity of epi-c3 analogues of cryptophycin-24.

Buck SB, Huff JK, Himes RH, Georg GI.

J Med Chem. 2004 Jul 1;47(14):3697-9.

PMID:
15214797
3.

Halohydrin analogues of cryptophycin 1: synthesis and biological activity.

Georg GI, Ali SM, Stella VJ, Waugh WN, Himes RH.

Bioorg Med Chem Lett. 1998 Aug 4;8(15):1959-62.

PMID:
9873466
4.

Cryptophycin affinity labels: synthesis and biological activity of a benzophenone analogue of cryptophycin-24.

Vidya R, Eggen M, Georg GI, Himes RH.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):757-60.

PMID:
12639575
5.

Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region).

Varie DL, Shih C, Hay DA, Andis SL, Corbett TH, Gossett LS, Janisse SK, Martinelli MJ, Moher ED, Schultz RM, Toth JE.

Bioorg Med Chem Lett. 1999 Feb 8;9(3):369-74.

PMID:
10091686
6.

First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues.

Smith AB 3rd, Cho YS, Zawacki LE, Hirschmann R, Pettit GR.

Org Lett. 2001 Dec 13;3(25):4063-6.

PMID:
11735585
7.

A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.

Al-Awar RS, Ray JE, Schultz RM, Andis SL, Kennedy JH, Moore RE, Liang J, Golakoti T, Subbaraju GV, Corbett TH.

J Med Chem. 2003 Jul 3;46(14):2985-3007.

PMID:
12825938
8.

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.

Liou JP, Chang YL, Kuo FM, Chang CW, Tseng HY, Wang CC, Yang YN, Chang JY, Lee SJ, Hsieh HP.

J Med Chem. 2004 Aug 12;47(17):4247-57.

PMID:
15293996
9.

Synthesis and biological evaluation of novel cryptophycin analogs with modification in the beta-alanine region.

Shih C, Gossett LS, Gruber JM, Grossman CS, Andis SL, Schultz RM, Worzalla JF, Corbett TH, Metz JT.

Bioorg Med Chem Lett. 1999 Jan 4;9(1):69-74.

PMID:
9990459
10.

Total synthesis of cryptophycin-24 (Arenastatin A) amenable to structural modifications in the C16 side chain.

Eggen M, Mossman CJ, Buck SB, Nair SK, Bhat L, Ali SM, Reiff EA, Boge TC, Georg GI.

J Org Chem. 2000 Nov 17;65(23):7792-9.

PMID:
11073583
11.

Synthesis and cytotoxicity studies of new cryptophycin analogues.

Liu WL, Zhang JC, Jiang FQ, Fu L.

Arch Pharm (Weinheim). 2009 Oct;342(10):577-83. doi: 10.1002/ardp.200900067.

PMID:
19714674
12.
13.

Cryptophycins-309, 249 and other cryptophycin analogs: preclinical efficacy studies with mouse and human tumors.

Liang J, Moore RE, Moher ED, Munroe JE, Al-awar RS, Hay DA, Varie DL, Zhang TY, Aikins JA, Martinelli MJ, Shih C, Ray JE, Gibson LL, Vasudevan V, Polin L, White K, Kushner J, Simpson C, Pugh S, Corbett TH.

Invest New Drugs. 2005 Jun;23(3):213-24.

PMID:
15868377
14.

Benzoylphenylurea sulfur analogues with potent antitumor activity.

Hallur G, Jimeno A, Dalrymple S, Zhu T, Jung MK, Hidalgo M, Isaacs JT, Sukumar S, Hamel E, Khan SR.

J Med Chem. 2006 Apr 6;49(7):2357-60.

PMID:
16570932
15.
16.

Novel cryptophycin antitumor agents: synthesis and cytotoxicity of fragment "B" analogues.

Patel VF, Andis SL, Kennedy JH, Ray JE, Schultz RM.

J Med Chem. 1999 Jul 15;42(14):2588-603.

PMID:
10411479
17.

Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents.

Liou JP, Mahindroo N, Chang CW, Guo FM, Lee SW, Tan UK, Yeh TK, Kuo CC, Chang YW, Lu PH, Tung YS, Lin KT, Chang JY, Hsieh HP.

ChemMedChem. 2006 Oct;1(10):1106-18.

PMID:
16952120
18.

Mechanism of action of the unusually potent microtubule inhibitor cryptophycin 1.

Panda D, Himes RH, Moore RE, Wilson L, Jordan MA.

Biochemistry. 1997 Oct 21;36(42):12948-53.

PMID:
9335554
19.

Synthesis, conformational analysis, and cytotoxicity of new analogues of the natural cyclodepsipeptide jaspamide.

Terracciano S, Bruno I, Bifulco G, Copper JE, Smith CD, Gomez-Paloma L, Riccio R.

J Nat Prod. 2004 Aug;67(8):1325-31.

PMID:
15332850
20.

A systematic SAR study of C10 modified paclitaxel analogues using a combinatorial approach.

Liu Y, Ali SM, Boge TC, Georg GI, Victory S, Zygmunt J, Marquez RT, Himes RH.

Comb Chem High Throughput Screen. 2002 Feb;5(1):39-48.

PMID:
11860338

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