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Items: 1 to 20 of 211

1.

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis.

Di Stefano V, Rinaldo C, Sacchi A, Soddu S, D'Orazi G.

Exp Cell Res. 2004 Feb 15;293(2):311-20.

PMID:
14729469
2.

Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells.

Puca R, Nardinocchi L, Pistritto G, D'Orazi G.

Gynecol Oncol. 2008 Jun;109(3):403-10. doi: 10.1016/j.ygyno.2008.02.018. Epub 2008 Apr 18.

PMID:
18395248
3.

HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage.

Di Stefano V, Soddu S, Sacchi A, D'Orazi G.

Oncogene. 2005 Aug 18;24(35):5431-42.

PMID:
15897882
4.

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.

Rui Y, Xu Z, Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC.

EMBO J. 2004 Nov 24;23(23):4583-94. Epub 2004 Nov 4.

5.

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, Gostissa M, Coen S, Marchetti A, Del Sal G, Piaggio G, Fanciulli M, Appella E, Soddu S.

Nat Cell Biol. 2002 Jan;4(1):11-9.

PMID:
11780126
6.

HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.

Di Stefano V, Mattiussi M, Sacchi A, D'Orazi G.

FEBS Lett. 2005 Oct 24;579(25):5473-80. Epub 2005 Sep 27.

7.

HIPK2 modulates p53 activity towards pro-apoptotic transcription.

Puca R, Nardinocchi L, Sacchi A, Rechavi G, Givol D, D'Orazi G.

Mol Cancer. 2009 Oct 14;8:85. doi: 10.1186/1476-4598-8-85.

8.

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.

Hofmann TG, Möller A, Sirma H, Zentgraf H, Taya Y, Dröge W, Will H, Schmitz ML.

Nat Cell Biol. 2002 Jan;4(1):1-10.

PMID:
11740489
9.

Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1.

Choi DW, Seo YM, Kim EA, Sung KS, Ahn JW, Park SJ, Lee SR, Choi CY.

J Biol Chem. 2008 Feb 22;283(8):4682-9. Epub 2007 Dec 19.

10.

TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

Tomasini R, Samir AA, Carrier A, Isnardon D, Cecchinelli B, Soddu S, Malissen B, Dagorn JC, Iovanna JL, Dusetti NJ.

J Biol Chem. 2003 Sep 26;278(39):37722-9. Epub 2003 Jul 7.

11.

Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells.

Nardinocchi L, Puca R, Givol D, D'Orazi G.

FEBS Lett. 2010 Oct 8;584(19):4253-8. doi: 10.1016/j.febslet.2010.09.018. Epub 2010 Sep 16.

12.

Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.

Kim EJ, Park JS, Um SJ.

J Biol Chem. 2002 Aug 30;277(35):32020-8. Epub 2002 Mar 29.

13.

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function.

Di Stefano V, Blandino G, Sacchi A, Soddu S, D'Orazi G.

Oncogene. 2004 Jul 1;23(30):5185-92.

PMID:
15122315
14.

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

Gresko E, Roscic A, Ritterhoff S, Vichalkovski A, del Sal G, Schmitz ML.

EMBO J. 2006 May 3;25(9):1883-94. Epub 2006 Apr 6.

15.

Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.

Li Q, Wang X, Wu X, Rui Y, Liu W, Wang J, Wang X, Liou YC, Ye Z, Lin SC.

Cancer Res. 2007 Jan 1;67(1):66-74.

16.

Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation.

Moehlenbrink J, Bitomsky N, Hofmann TG.

Cancer Lett. 2010 Jun 1;292(1):119-24. doi: 10.1016/j.canlet.2009.11.016. Epub 2009 Dec 16.

PMID:
20018442
17.
18.

Zyxin is a critical regulator of the apoptotic HIPK2-p53 signaling axis.

Crone J, Glas C, Schultheiss K, Moehlenbrink J, Krieghoff-Henning E, Hofmann TG.

Cancer Res. 2011 Mar 15;71(6):2350-9. doi: 10.1158/0008-5472.CAN-10-3486. Epub 2011 Jan 19.

19.

Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells.

Wesierska-Gadek J, Schmitz ML, Ranftler C.

J Cell Biochem. 2007 Mar 1;100(4):865-74.

PMID:
17203463
20.

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, Moretti F, Soddu S.

Mol Cell. 2007 Mar 9;25(5):739-50.

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