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Items: 1 to 20 of 106

1.

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.

Turk BE, Wong TY, Schwarzenbacher R, Jarrell ET, Leppla SH, Collier RJ, Liddington RC, Cantley LC.

Nat Struct Mol Biol. 2004 Jan;11(1):60-6. Epub 2003 Dec 29.

PMID:
14718924
2.

Substrate recognition of anthrax lethal factor examined by combinatorial and pre-steady-state kinetic approaches.

Zakharova MY, Kuznetsov NA, Dubiley SA, Kozyr AV, Fedorova OS, Chudakov DM, Knorre DG, Shemyakin IG, Gabibov AG, Kolesnikov AV.

J Biol Chem. 2009 Jul 3;284(27):17902-13. doi: 10.1074/jbc.M807510200. Epub 2009 Apr 9.

3.

The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited.

Tonello F, Ascenzi P, Montecucco C.

J Biol Chem. 2003 Oct 10;278(41):40075-8. Epub 2003 Jul 29.

4.

Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages.

Vitale G, Pellizzari R, Recchi C, Napolitani G, Mock M, Montecucco C.

Biochem Biophys Res Commun. 1998 Jul 30;248(3):706-11.

PMID:
9703991
5.

Insights into the anthrax lethal factor-substrate interaction and selectivity using docking and molecular dynamics simulations.

Dalkas GA, Papakyriakou A, Vlamis-Gardikas A, Spyroulias GA.

Protein Sci. 2009 Aug;18(8):1774-85. doi: 10.1002/pro.169.

6.
7.

Anthrax lethal factor inhibition.

Shoop WL, Xiong Y, Wiltsie J, Woods A, Guo J, Pivnichny JV, Felcetto T, Michael BF, Bansal A, Cummings RT, Cunningham BR, Friedlander AM, Douglas CM, Patel SB, Wisniewski D, Scapin G, Salowe SP, Zaller DM, Chapman KT, Scolnick EM, Schmatz DM, Bartizal K, MacCoss M, Hermes JD.

Proc Natl Acad Sci U S A. 2005 May 31;102(22):7958-63. Epub 2005 May 23.

8.

Yeast-hybrid based high-throughput assay for identification of anthrax lethal factor inhibitors.

Kim J, Park HC, Gedi V, Park HY, Roberts AG, Atkins WM, Yoon MY.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):517-22. doi: 10.1016/j.bbrc.2010.12.015. Epub 2010 Dec 6.

PMID:
21144836
9.

Discovery and development of anthrax lethal factor metalloproteinase inhibitors.

Turk BE.

Curr Pharm Biotechnol. 2008 Feb;9(1):24-33. Review.

PMID:
18289054
10.

Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies.

Johnson SL, Jung D, Forino M, Chen Y, Satterthwait A, Rozanov DV, Strongin AY, Pellecchia M.

J Med Chem. 2006 Jan 12;49(1):27-30.

11.

Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides.

Lee LV, Bower KE, Liang FS, Shi J, Wu D, Sucheck SJ, Vogt PK, Wong CH.

J Am Chem Soc. 2004 Apr 21;126(15):4774-5.

PMID:
15080670
12.

Screening inhibitors of anthrax lethal factor.

Tonello F, Seveso M, Marin O, Mock M, Montecucco C.

Nature. 2002 Jul 25;418(6896):386.

PMID:
12140548
13.

Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin.

Wang W, Mulakala C, Ward SC, Jung G, Luong H, Pham D, Waring AJ, Kaznessis Y, Lu W, Bradley KA, Lehrer RI.

J Biol Chem. 2006 Oct 27;281(43):32755-64. Epub 2006 Jun 21.

14.

Identification of small molecule inhibitors of anthrax lethal factor.

Panchal RG, Hermone AR, Nguyen TL, Wong TY, Schwarzenbacher R, Schmidt J, Lane D, McGrath C, Turk BE, Burnett J, Aman MJ, Little S, Sausville EA, Zaharevitz DW, Cantley LC, Liddington RC, Gussio R, Bavari S.

Nat Struct Mol Biol. 2004 Jan;11(1):67-72. Epub 2003 Dec 29.

PMID:
14718925
15.

Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.

Maize KM, Kurbanov EK, De La Mora-Rey T, Geders TW, Hwang DJ, Walters MA, Johnson RL, Amin EA, Finzel BC.

Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):2813-22. doi: 10.1107/S1399004714018161. Epub 2014 Oct 16.

16.

Anthrax X-rayed: new opportunities for biodefence.

Stubbs MT.

Trends Pharmacol Sci. 2002 Dec;23(12):539-41. Review.

PMID:
12457764
17.

Cross-inhibition between furin and lethal factor inhibitors.

Peinado JR, Kacprzak MM, Leppla SH, Lindberg I.

Biochem Biophys Res Commun. 2004 Aug 27;321(3):601-5.

PMID:
15358148
18.

Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.

Kurbanov EK, Chiu TL, Solberg J, Francis S, Maize KM, Fernandez J, Johnson RL, Hawkinson JE, Walters MA, Finzel BC, Amin EA.

J Med Chem. 2015 Nov 12;58(21):8723-33. doi: 10.1021/acs.jmedchem.5b01446. Epub 2015 Oct 29.

PMID:
26492514
19.

Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway.

Wickliffe KE, Leppla SH, Moayeri M.

Cell Microbiol. 2008 Jun;10(6):1352-62. doi: 10.1111/j.1462-5822.2008.01131.x. Epub 2008 Feb 5.

20.

Anthrax lethal factor inhibitors as potential countermeasure of the infection.

Kumar BV, Malik S, Grandhi P, Dayam R, Sarma JA.

Curr Top Med Chem. 2014;14(17):1977-89. Review.

PMID:
25262802

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