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Items: 1 to 20 of 61

1.

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes.

Lum PY, Armour CD, Stepaniants SB, Cavet G, Wolf MK, Butler JS, Hinshaw JC, Garnier P, Prestwich GD, Leonardson A, Garrett-Engele P, Rush CM, Bard M, Schimmack G, Phillips JW, Roberts CJ, Shoemaker DD.

Cell. 2004 Jan 9;116(1):121-37.

2.

Yeast as a tool to uncover the cellular targets of drugs.

Sturgeon CM, Kemmer D, Anderson HJ, Roberge M.

Biotechnol J. 2006 Mar;1(3):289-98. Review.

PMID:
16897709
3.

Chemical-genetic approaches for exploring the mode of action of natural products.

Lopez A, Parsons AB, Nislow C, Giaever G, Boone C.

Prog Drug Res. 2008;66:237, 239-71. Review.

PMID:
18416308
4.

Genome-wide analysis of the expression profile of Saccharomyces cerevisiae in response to treatment with the plant isoflavone, wighteone, as a potential antifungal agent.

Yin H, Zhao Y, Zhang Y, Zhang H, Xu L, Zou Z, Yang W, Cheng J, Zhou Y.

Biotechnol Lett. 2006 Jan;28(2):99-105.

PMID:
16369693
5.

Yeast as a drug discovery platform in Huntington's and Parkinson's diseases.

Outeiro TF, Giorgini F.

Biotechnol J. 2006 Mar;1(3):258-69. Review.

PMID:
16897706
6.

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast.

Giaever G, Flaherty P, Kumm J, Proctor M, Nislow C, Jaramillo DF, Chu AM, Jordan MI, Arkin AP, Davis RW.

Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):793-8. Epub 2004 Jan 12.

7.

Genomic and genetic approaches for the identification of antifungal drug targets.

Agarwal AK, Xu T, Jacob MR, Feng Q, Li XC, Walker LA, Clark AM.

Infect Disord Drug Targets. 2008 Mar;8(1):2-15. Review.

PMID:
18473903
8.

Development of a novel oligonucleotide array-based transcription factor assay platform for genome-wide active transcription factor profiling in Saccharomyces cerevisiae.

Zhao Y, Shao W, Wei H, Qiao J, Lu Y, Sun Y, Mitchelson K, Cheng J, Zhou Y.

J Proteome Res. 2008 Mar;7(3):1315-25. doi: 10.1021/pr700642g. Epub 2008 Jan 26.

PMID:
18220337
9.

Yeast genomics and drug target identification.

Bharucha N, Kumar A.

Comb Chem High Throughput Screen. 2007 Sep;10(8):618-34. Review.

PMID:
18045076
10.

Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.

Ericson E, Gebbia M, Heisler LE, Wildenhain J, Tyers M, Giaever G, Nislow C.

PLoS Genet. 2008 Aug 8;4(8):e1000151. doi: 10.1371/journal.pgen.1000151.

11.

A genome-wide screen for essential yeast genes that affect telomere length maintenance.

Ungar L, Yosef N, Sela Y, Sharan R, Ruppin E, Kupiec M.

Nucleic Acids Res. 2009 Jul;37(12):3840-9. doi: 10.1093/nar/gkp259. Epub 2009 Apr 22.

12.

Genome-wide expression profile of steroid response in Saccharomyces cerevisiae.

Banerjee D, Pillai B, Karnani N, Mukhopadhyay G, Prasad R.

Biochem Biophys Res Commun. 2004 Apr 30;317(2):406-13.

PMID:
15063773
13.

The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.

Nookaew I, Jewett MC, Meechai A, Thammarongtham C, Laoteng K, Cheevadhanarak S, Nielsen J, Bhumiratana S.

BMC Syst Biol. 2008 Aug 7;2:71. doi: 10.1186/1752-0509-2-71.

14.

Combined analysis of expression data and transcription factor binding sites in the yeast genome.

Nagaraj VH, O'Flanagan RA, Bruning AR, Mathias JR, Vershon AK, Sengupta AM.

BMC Genomics. 2004 Aug 26;5(1):59.

15.
16.

Yeast on drugs: Saccharomyces cerevisiae as a tool for anticancer drug research.

Menacho-Márquez M, Murguía JR.

Clin Transl Oncol. 2007 Apr;9(4):221-8. Review.

PMID:
17462974
17.

Differentiating mechanisms of toxicity using global gene expression analysis in Saccharomyces cerevisiae.

Caba E, Dickinson DA, Warnes GR, Aubrecht J.

Mutat Res. 2005 Aug 4;575(1-2):34-46.

PMID:
15878181
18.

A high-throughput screen to identify novel calcineurin inhibitors.

Margassery LM, Kennedy J, O'Gara F, Dobson AD, Morrissey JP.

J Microbiol Methods. 2012 Jan;88(1):63-6. doi: 10.1016/j.mimet.2011.10.012. Epub 2011 Oct 26.

PMID:
22056231
19.
20.

Old drugs, new tricks: using genetically sensitized yeast to reveal drug targets.

Hughes T, Andrews B, Boone C.

Cell. 2004 Jan 9;116(1):5-7. Review.

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