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Items: 1 to 20 of 108

1.

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA, Sen S.

Nat Genet. 2004 Jan;36(1):55-62. Epub 2003 Dec 14.

PMID:
14702041
3.

Aurora B kinase phosphorylates and instigates degradation of p53.

Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):E1513-22. doi: 10.1073/pnas.1110287109. Epub 2012 May 18.

4.

Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K, Masuyama N, Gotoh Y.

J Biol Chem. 2002 Jun 14;277(24):21843-50. Epub 2002 Mar 28.

5.

A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2.

Hsueh KW, Fu SL, Chang CB, Chang YL, Lin CH.

Biochim Biophys Acta. 2013 Feb;1834(2):508-15. doi: 10.1016/j.bbapap.2012.11.005. Epub 2012 Nov 28.

PMID:
23201157
6.
7.

Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation.

Cai Q, Xiao B, Si H, Cervini A, Gao J, Lu J, Upadhyay SK, Verma SC, Robertson ES.

PLoS Pathog. 2012;8(3):e1002566. doi: 10.1371/journal.ppat.1002566. Epub 2012 Mar 1.

8.

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.

Chen L, Gilkes DM, Pan Y, Lane WS, Chen J.

EMBO J. 2005 Oct 5;24(19):3411-22. Epub 2005 Sep 15.

9.

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation.

Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC.

Nat Cell Biol. 2001 Nov;3(11):973-82. Erratum in: Nat Cell Biol 2002 Sep;4(9):736.

PMID:
11715018
10.

HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage.

Pääjärvi G, Roudier E, Crisby M, Högberg J, Stenius U.

FASEB J. 2005 Mar;19(3):476-8. Epub 2004 Dec 29.

PMID:
15625077
11.

Interplay between Mdm2 and HIPK2 in the DNA damage response.

Zhang XP, Liu F, Wang W.

J R Soc Interface. 2014 Jul 6;11(96). pii: 20140319. doi: 10.1098/rsif.2014.0319.

12.

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation.

Feng J, Tamaskovic R, Yang Z, Brazil DP, Merlo A, Hess D, Hemmings BA.

J Biol Chem. 2004 Aug 20;279(34):35510-7. Epub 2004 May 28.

13.

Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells.

Hjerrild M, Milne D, Dumaz N, Hay T, Issinger OG, Meek D.

Biochem J. 2001 Apr 15;355(Pt 2):347-56.

14.

Determinants for the efficiency of anticancer drugs targeting either Aurora-A or Aurora-B kinases in human colon carcinoma cells.

Kaestner P, Stolz A, Bastians H.

Mol Cancer Ther. 2009 Jul;8(7):2046-56. doi: 10.1158/1535-7163.MCT-09-0323. Epub 2009 Jul 7.

15.

Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.

Dias SS, Hogan C, Ochocka AM, Meek DW.

FEBS Lett. 2009 Nov 19;583(22):3543-8. doi: 10.1016/j.febslet.2009.09.057. Epub 2009 Oct 13.

16.

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.

Mayo LD, Donner DB.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11598-603. Epub 2001 Aug 14.

17.

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.

Vega FM, Sevilla A, Lazo PA.

Mol Cell Biol. 2004 Dec;24(23):10366-80.

18.
19.

Integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to Aurora-A kinase inhibitors.

Shionome Y, Yan L, Liu S, Saeki T, Ouchi T.

PLoS One. 2013;8(1):e55457. doi: 10.1371/journal.pone.0055457. Epub 2013 Jan 31.

20.

Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation.

Wang X, Zhou YX, Qiao W, Tominaga Y, Ouchi M, Ouchi T, Deng CX.

Oncogene. 2006 Nov 16;25(54):7148-58. Epub 2006 May 22.

PMID:
16715125

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