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Items: 1 to 20 of 259

1.

Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.

Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF.

Diabetes. 2004 Jan;53(1):61-6.

2.

Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.

Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB.

J Biol Chem. 2007 Aug 17;282(33):23829-40. Epub 2007 Jun 1.

3.

Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance.

Nieto-Vazquez I, Fernández-Veledo S, de Alvaro C, Rondinone CM, Valverde AM, Lorenzo M.

Diabetes. 2007 Feb;56(2):404-13.

4.

Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.

Haj FG, Zabolotny JM, Kim YB, Kahn BB, Neel BG.

J Biol Chem. 2005 Apr 15;280(15):15038-46. Epub 2005 Feb 7.

5.

Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice.

Arroba AI, Revuelta-Cervantes J, Menes L, González-Rodríguez Á, Pardo V, de la Villa P, Burks DJ, Valverde ÁM.

Invest Ophthalmol Vis Sci. 2013 Jun 19;54(6):4215-25. doi: 10.1167/iovs.12-11438.

PMID:
23702782
6.

Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

Rondinone CM, Trevillyan JM, Clampit J, Gum RJ, Berg C, Kroeger P, Frost L, Zinker BA, Reilly R, Ulrich R, Butler M, Monia BP, Jirousek MR, Waring JF.

Diabetes. 2002 Aug;51(8):2405-11.

7.

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation.

Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF.

J Neurosci. 2003 Aug 6;23(18):7084-92.

8.

The role of protein tyrosine phosphatase 1B in Ras signaling.

Dubé N, Cheng A, Tremblay ML.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1834-9. Epub 2004 Feb 6.

9.

Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells.

Clampit JE, Meuth JL, Smith HT, Reilly RM, Jirousek MR, Trevillyan JM, Rondinone CM.

Biochem Biophys Res Commun. 2003 Jan 10;300(2):261-7.

PMID:
12504077
10.

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice.

Cantley J, Choudhury AI, Asare-Anane H, Selman C, Lingard S, Heffron H, Herrera P, Persaud SJ, Withers DJ.

Diabetologia. 2007 Jun;50(6):1248-56. Epub 2007 Mar 29.

PMID:
17393136
11.

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

Simmgen M, Knauf C, Lopez M, Choudhury AI, Charalambous M, Cantley J, Bedford DC, Claret M, Iglesias MA, Heffron H, Cani PD, Vidal-Puig A, Burcelin R, Withers DJ.

Diabetologia. 2006 Mar;49(3):552-61. Epub 2006 Jan 11.

PMID:
16404553
12.

Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B.

Wu Y, Ou-Yang JP, Wu K, Wang Y, Zhou YF, Wen CY.

Acta Pharmacol Sin. 2005 Mar;26(3):345-52.

13.

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

Kubota N, Terauchi Y, Tobe K, Yano W, Suzuki R, Ueki K, Takamoto I, Satoh H, Maki T, Kubota T, Moroi M, Okada-Iwabu M, Ezaki O, Nagai R, Ueta Y, Kadowaki T, Noda T.

J Clin Invest. 2004 Oct;114(7):917-27.

14.

Pdx1 restores beta cell function in Irs2 knockout mice.

Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF.

J Clin Invest. 2002 May;109(9):1193-201.

15.

Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.

Bentires-Alj M, Neel BG.

Cancer Res. 2007 Mar 15;67(6):2420-4. Epub 2007 Mar 8.

16.

Protein tyrosine phosphatase 1B: a novel target for type 2 diabetes and obesity.

Ramachandran C, Kennedy BP.

Curr Top Med Chem. 2003;3(7):749-57. Review.

PMID:
12678842
17.

Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice.

Suzuki R, Tobe K, Aoyama M, Inoue A, Sakamoto K, Yamauchi T, Kamon J, Kubota N, Terauchi Y, Yoshimatsu H, Matsuhisa M, Nagasaka S, Ogata H, Tokuyama K, Nagai R, Kadowaki T.

J Biol Chem. 2004 Jun 11;279(24):25039-49. Epub 2004 Mar 17.

18.

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF.

Nat Genet. 1999 Sep;23(1):32-40.

PMID:
10471495
19.

Ontogenetic characteristics of enzyme activities and plasma metabolites in C57BL/6J:Jcl mice deficient in insulin receptor substrate 2.

Hashimoto H, Arai T, Takeguchi A, Hioki K, Ohnishi Y, Kawai K, Ito M, Suzuki R, Yamauchi T, Ohsugi M, Saito M, Ueyama Y, Tobe K, Kadowaki T, Tamaoki N, Kosaka K.

Comp Med. 2006 Jun;56(3):176-87.

PMID:
16774126
20.

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

Gonzalez-Rodriguez A, Clampit JE, Escribano O, Benito M, Rondinone CM, Valverde AM.

Endocrinology. 2007 Feb;148(2):594-608. Epub 2006 Oct 26.

PMID:
17068137

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