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Mechanisms of caspase activation.

Boatright KM, Salvesen GS.

Curr Opin Cell Biol. 2003 Dec;15(6):725-31. Review.


Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis.

Sohn D, Schulze-Osthoff K, Jänicke RU.

J Biol Chem. 2005 Feb 18;280(7):5267-73. Epub 2004 Dec 15.


Caspase mechanisms.

Salvesen GS, Riedl SJ.

Adv Exp Med Biol. 2008;615:13-23. doi: 10.1007/978-1-4020-6554-5_2. Review.


Activation of caspases-8 and -10 by FLIP(L).

Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS.

Biochem J. 2004 Sep 1;382(Pt 2):651-7.


Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.

Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR.

J Biol Chem. 2010 May 28;285(22):16632-42. doi: 10.1074/jbc.M109.095083. Epub 2010 Mar 22. Erratum in: J Biol Chem. 2014 Mar 7;289(10):6838.


Pro-caspase-3 is a major physiologic target of caspase-8.

Stennicke HR, Jürgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS.

J Biol Chem. 1998 Oct 16;273(42):27084-90.


Caspase activation: revisiting the induced proximity model.

Shi Y.

Cell. 2004 Jun 25;117(7):855-8. Review.


Caspase activation: the induced-proximity model.

Salvesen GS, Dixit VM.

Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):10964-7. Review.


Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases.

Chang DW, Ditsworth D, Liu H, Srinivasula SM, Alnemri ES, Yang X.

J Biol Chem. 2003 May 9;278(19):16466-9. Epub 2003 Mar 13.


Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts.

Swanton E, Savory P, Cosulich S, Clarke P, Woodman P.

Oncogene. 1999 Mar 11;18(10):1781-7.


Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

Yang X, Stennicke HR, Wang B, Green DR, Jänicke RU, Srinivasan A, Seth P, Salvesen GS, Froelich CJ.

J Biol Chem. 1998 Dec 18;273(51):34278-83.


Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.

Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR, Martin SJ.

J Cell Biol. 1999 Jan 25;144(2):281-92.


Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activation.

Marcelli M, Marani M, Li X, Sturgis L, Haidacher SJ, Trial JA, Mannucci R, Nicoletti I, Denner L.

Prostate. 2000 Mar 1;42(4):260-73.


The apoptosome activates caspase-9 by dimerization.

Pop C, Timmer J, Sperandio S, Salvesen GS.

Mol Cell. 2006 Apr 21;22(2):269-75.


Imaging-based methods for assessing caspase activity in single cells.

Parsons MJ, Rehm M, Bouchier-Hayes L.

Cold Spring Harb Protoc. 2015 Jan 5;2015(1):pdb.top070342. doi: 10.1101/pdb.top070342.


Taxol induces caspase-10-dependent apoptosis.

Park SJ, Wu CH, Gordon JD, Zhong X, Emami A, Safa AR.

J Biol Chem. 2004 Dec 3;279(49):51057-67. Epub 2004 Sep 27.


Structural basis for the activation of human procaspase-7.

Riedl SJ, Fuentes-Prior P, Renatus M, Kairies N, Krapp S, Huber R, Salvesen GS, Bode W.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14790-5.


Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes.

Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M.

Mol Cell. 2006 Aug;23(4):509-21.


Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway.

Wagner KW, Engels IH, Deveraux QL.

J Biol Chem. 2004 Aug 13;279(33):35047-52. Epub 2004 Jun 1.

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