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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.

Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, Cattoretti G, Levine B.

J Clin Invest. 2003 Dec;112(12):1809-20. Epub 2003 Nov 24.


Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.

Yue Z, Jin S, Yang C, Levine AJ, Heintz N.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15077-82. Epub 2003 Dec 1.


Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B.

Nature. 1999 Dec 9;402(6762):672-6.


Role of autophagy in breast cancer.

Karantza-Wadsworth V, White E.

Autophagy. 2007 Nov-Dec;3(6):610-3. Epub 2007 Aug 14.


The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function.

Furuya N, Yu J, Byfield M, Pattingre S, Levine B.

Autophagy. 2005 Apr;1(1):46-52. Epub 2005 Apr 17.


Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.

Li H, Wang P, Sun Q, Ding WX, Yin XM, Sobol RW, Stolz DB, Yu J, Zhang L.

Cancer Res. 2011 May 15;71(10):3625-34. doi: 10.1158/0008-5472.CAN-10-4475. Epub 2011 Mar 28.


Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro.

Correa RJ, Valdes YR, Shepherd TG, DiMattia GE.

J Ovarian Res. 2015 Aug 4;8:52. doi: 10.1186/s13048-015-0182-y.


Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis.

Lee SJ, Kim HP, Jin Y, Choi AM, Ryter SW.

Autophagy. 2011 Aug;7(8):829-39. Epub 2011 Aug 1.


Cardiac autophagy is a maladaptive response to hemodynamic stress.

Zhu H, Tannous P, Johnstone JL, Kong Y, Shelton JM, Richardson JA, Le V, Levine B, Rothermel BA, Hill JA.

J Clin Invest. 2007 Jul;117(7):1782-93.


Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis.

Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, Liang C, Jung JU, Cheng JQ, Mulé JJ, Pledger WJ, Wang HG.

Nat Cell Biol. 2007 Oct;9(10):1142-51. Epub 2007 Sep 23.


Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.

Høyer-Hansen M, Bastholm L, Mathiasen IS, Elling F, Jäättelä M.

Cell Death Differ. 2005 Oct;12(10):1297-309.


The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.

Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, Wyss-Coray T.

J Clin Invest. 2008 Jun;118(6):2190-9. doi: 10.1172/JCI33585.


Downregulation of autophagy by Bcl-2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis.

Oh S, Xiaofei E, Ni D, Pirooz SD, Lee JY, Lee D, Zhao Z, Lee S, Lee H, Ku B, Kowalik T, Martin SE, Oh BH, Jung JU, Liang C.

Cell Death Differ. 2011 Mar;18(3):452-64. doi: 10.1038/cdd.2010.116. Epub 2010 Oct 1.


[Effect and mechanism of an autophagy gene beclin 1 on cervical cancer HeLa cells].

Wang ZH, Li L, Duan ZL.

Zhonghua Fu Chan Ke Za Zhi. 2011 Feb;46(2):125-31. Chinese.


Immunohistochemical evidence for an impairment of autophagy in tumorigenesis of gastric carcinoids and adenocarcinomas in rodent models and patients.

Vigen RA, Kodama Y, Viset T, Fossmark R, Waldum H, Kidd M, Wang TC, Modlin IM, Chen D, Zhao CM.

Histol Histopathol. 2013 Apr;28(4):531-42. doi: 10.14670/HH-28.531. Epub 2013 Feb 7.


Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis.

Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, White E.

Genes Dev. 2007 Jul 1;21(13):1621-35.


Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.

Huo Y, Cai H, Teplova I, Bowman-Colin C, Chen G, Price S, Barnard N, Ganesan S, Karantza V, White E, Xia B.

Cancer Discov. 2013 Aug;3(8):894-907. doi: 10.1158/2159-8290.CD-13-0011. Epub 2013 May 6.


Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.

Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B, Sadoshima J.

Circ Res. 2007 Mar 30;100(6):914-22. Epub 2007 Mar 1.


Downregulation of Beclin 1 and impairment of autophagy in a small population of colorectal cancer.

Chen Z, Li Y, Zhang C, Yi H, Wu C, Wang J, Liu Y, Tan J, Wen J.

Dig Dis Sci. 2013 Oct;58(10):2887-94. doi: 10.1007/s10620-013-2732-8. Epub 2013 Jun 29.

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