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Items: 1 to 20 of 89

1.

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.

Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14. Epub 2003 Nov 10.

2.

WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice.

Bergaya S, Faure S, Baudrie V, Rio M, Escoubet B, Bonnin P, Henrion D, Loirand G, Achard JM, Jeunemaitre X, Hadchouel J.

Hypertension. 2011 Sep;58(3):439-45. doi: 10.1161/HYPERTENSIONAHA.111.172429. Epub 2011 Jul 18.

3.

Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase.

Liu Z, Wang HR, Huang CL.

J Biol Chem. 2009 May 1;284(18):12198-206. doi: 10.1074/jbc.M806551200. Epub 2009 Feb 25.

4.

Human hypertension caused by mutations in WNK kinases.

Wilson FH, Disse-Nicodème S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP.

Science. 2001 Aug 10;293(5532):1107-12.

5.

Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform.

Delaloy C, Lu J, Houot AM, Disse-Nicodeme S, Gasc JM, Corvol P, Jeunemaitre X.

Mol Cell Biol. 2003 Dec;23(24):9208-21.

6.
7.

Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II.

Shekarabi M, Girard N, Rivière JB, Dion P, Houle M, Toulouse A, Lafrenière RG, Vercauteren F, Hince P, Laganiere J, Rochefort D, Faivre L, Samuels M, Rouleau GA.

J Clin Invest. 2008 Jul;118(7):2496-505. doi: 10.1172/JCI34088.

8.

WNK kinases regulate thiazide-sensitive Na-Cl cotransport.

Yang CL, Angell J, Mitchell R, Ellison DH.

J Clin Invest. 2003 Apr;111(7):1039-45.

9.

Pathogenesis of pseudohypoaldosteronism type 2 by WNK1 mutations.

Bergaya S, Vidal-Petiot E, Jeunemaitre X, Hadchouel J.

Curr Opin Nephrol Hypertens. 2012 Jan;21(1):39-45. doi: 10.1097/MNH.0b013e32834d2fde. Review.

PMID:
22080857
10.

WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron.

Vidal-Petiot E, Elvira-Matelot E, Mutig K, Soukaseum C, Baudrie V, Wu S, Cheval L, Huc E, Cambillau M, Bachmann S, Doucet A, Jeunemaitre X, Hadchouel J.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14366-71. doi: 10.1073/pnas.1304230110. Epub 2013 Aug 12.

11.

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.

Vitari AC, Deak M, Collins BJ, Morrice N, Prescott AR, Phelan A, Humphreys S, Alessi DR.

Biochem J. 2004 Feb 15;378(Pt 1):257-68.

12.

WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.

Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH.

Cell Res. 2005 Jan;15(1):6-10. Review.

13.

Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform.

Subramanya AR, Yang CL, Zhu X, Ellison DH.

Am J Physiol Renal Physiol. 2006 Mar;290(3):F619-24. Epub 2005 Oct 4.

14.

Deletion of WNK1 first intron results in misregulation of both isoforms in renal and extrarenal tissues.

Delaloy C, Elvira-Matelot E, Clemessy M, Zhou XO, Imbert-Teboul M, Houot AM, Jeunemaitre X, Hadchouel J.

Hypertension. 2008 Dec;52(6):1149-54. doi: 10.1161/HYPERTENSIONAHA.108.120899. Epub 2008 Oct 27.

15.

The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport.

Náray-Fejes-Tóth A, Snyder PM, Fejes-Tóth G.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17434-9. Epub 2004 Dec 6.

16.

Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells.

Ohta A, Yang SS, Rai T, Chiga M, Sasaki S, Uchida S.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):804-8. Epub 2006 Aug 24.

PMID:
16949040
17.

Common variation in with no-lysine kinase 1 (WNK1) and blood pressure responses to dietary sodium or potassium interventions- family-based association study.

Liu F, Zheng S, Mu J, Chu C, Wang L, Wang Y, Xiao H, Wang D, Cao Y, Ren K, Liu E, Yuan Z.

Circ J. 2013;77(1):169-74. Epub 2012 Oct 12.

18.

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.

Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22. Epub 2003 Aug 6.

19.

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.

Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH.

J Biol Chem. 2000 Jun 2;275(22):16795-801.

20.

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.

J Biol Chem. 2005 Dec 30;280(52):42685-93. Epub 2005 Oct 31.

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