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The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.

Offenhäuser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G.

Mol Biol Cell. 2004 Jan;15(1):91-8. Epub 2003 Oct 17.


Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.

Innocenti M, Frittoli E, Ponzanelli I, Falck JR, Brachmann SM, Di Fiore PP, Scita G.

J Cell Biol. 2003 Jan 6;160(1):17-23. Epub 2003 Jan 6.


An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine.

Scita G, Tenca P, Areces LB, Tocchetti A, Frittoli E, Giardina G, Ponzanelli I, Sini P, Innocenti M, Di Fiore PP.

J Cell Biol. 2001 Sep 3;154(5):1031-44. Epub 2001 Aug 27.


Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells.

Goicoechea S, Arneman D, Disanza A, Garcia-Mata R, Scita G, Otey CA.

J Cell Sci. 2006 Aug 15;119(Pt 16):3316-24. Epub 2006 Jul 25.


IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness.

Funato Y, Terabayashi T, Suenaga N, Seiki M, Takenawa T, Miki H.

Cancer Res. 2004 Aug 1;64(15):5237-44.


Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

Innocenti M, Tenca P, Frittoli E, Faretta M, Tocchetti A, Di Fiore PP, Scita G.

J Cell Biol. 2002 Jan 7;156(1):125-36. Epub 2002 Jan 3.


EPS8 and E3B1 transduce signals from Ras to Rac.

Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP.

Nature. 1999 Sep 16;401(6750):290-3.


Regulation of actin cytoskeleton architecture by Eps8 and Abi1.

Roffers-Agarwal J, Xanthos JB, Miller JR.

BMC Cell Biol. 2005 Oct 14;6:36.


Eps8 in the midst of GTPases.

Di Fiore PP, Scita G.

Int J Biochem Cell Biol. 2002 Oct;34(10):1178-83. Review.


Eps8 controls actin-based motility by capping the barbed ends of actin filaments.

Disanza A, Carlier MF, Stradal TE, Didry D, Frittoli E, Confalonieri S, Croce A, Wehland J, Di Fiore PP, Scita G.

Nat Cell Biol. 2004 Dec;6(12):1180-8. Epub 2004 Nov 21.


Chlamydial entry involves TARP binding of guanine nucleotide exchange factors.

Lane BJ, Mutchler C, Al Khodor S, Grieshaber SS, Carabeo RA.

PLoS Pathog. 2008 Mar;4(3):e1000014.


The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.

Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP.

Nature. 2000 Nov 16;408(6810):374-7.


Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.

Ong SH, Hadari YR, Gotoh N, Guy GR, Schlessinger J, Lax I.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6074-9. Epub 2001 May 15.


Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways.

Bosse T, Ehinger J, Czuchra A, Benesch S, Steffen A, Wu X, Schloen K, Niemann HH, Scita G, Stradal TE, Brakebusch C, Rottner K.

Mol Cell Biol. 2007 Oct;27(19):6615-28. Epub 2007 Aug 6.


Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis.

Chen H, Wu X, Pan ZK, Huang S.

Cancer Res. 2010 Dec 1;70(23):9979-90. doi: 10.1158/0008-5472.CAN-10-2394. Epub 2010 Nov 30.


Eps8, a tyrosine kinase substrate, is recruited to the cell cortex and dynamic F-actin upon cytoskeleton remodeling.

Provenzano C, Gallo R, Carbone R, Di Fiore PP, Falcone G, Castellani L, Alemà S.

Exp Cell Res. 1998 Jul 10;242(1):186-200.


Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.

Katso RM, Pardo OE, Palamidessi A, Franz CM, Marinov M, De Laurentiis A, Downward J, Scita G, Ridley AJ, Waterfield MD, Arcaro A.

Mol Biol Cell. 2006 Sep;17(9):3729-44. Epub 2006 Jun 14.


Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor.

Hayashi H, Ichihara M, Iwashita T, Murakami H, Shimono Y, Kawai K, Kurokawa K, Murakumo Y, Imai T, Funahashi H, Nakao A, Takahashi M.

Oncogene. 2000 Sep 14;19(39):4469-75.

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