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Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex.

Chacinska A, Rehling P, Guiard B, Frazier AE, Schulze-Specking A, Pfanner N, Voos W, Meisinger C.

EMBO J. 2003 Oct 15;22(20):5370-81.


Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes.

Yamamoto H, Esaki M, Kanamori T, Tamura Y, Nishikawa Si, Endo T.

Cell. 2002 Nov 15;111(4):519-28.


A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23.

Truscott KN, Kovermann P, Geissler A, Merlin A, Meijer M, Driessen AJ, Rassow J, Pfanner N, Wagner R.

Nat Struct Biol. 2001 Dec;8(12):1074-82.


The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel.

Geissler A, Chacinska A, Truscott KN, Wiedemann N, Brandner K, Sickmann A, Meyer HE, Meisinger C, Pfanner N, Rehling P.

Cell. 2002 Nov 15;111(4):507-18.


Role of Tim21 in mitochondrial translocation contact sites.

Mokranjac D, Popov-Celeketić D, Hell K, Neupert W.

J Biol Chem. 2005 Jun 24;280(25):23437-40. Epub 2005 May 4.


Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.

Chacinska A, Lind M, Frazier AE, Dudek J, Meisinger C, Geissler A, Sickmann A, Meyer HE, Truscott KN, Guiard B, Pfanner N, Rehling P.

Cell. 2005 Mar 25;120(6):817-29.


Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase.

van Wilpe S, Ryan MT, Hill K, Maarse AC, Meisinger C, Brix J, Dekker PJ, Moczko M, Wagner R, Meijer M, Guiard B, Hönlinger A, Pfanner N.

Nature. 1999 Sep 30;401(6752):485-9. Erratum in: Nature 2000 Nov 30;408(6812):616.


The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes.

Albrecht R, Rehling P, Chacinska A, Brix J, Cadamuro SA, Volkmer R, Guiard B, Pfanner N, Zeth K.

EMBO Rep. 2006 Dec;7(12):1233-8. Epub 2006 Nov 10.


Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria.

Mokranjac D, Sichting M, Popov-Celeketić D, Mapa K, Gevorkyan-Airapetov L, Zohary K, Hell K, Azem A, Neupert W.

Mol Biol Cell. 2009 Mar;20(5):1400-7. doi: 10.1091/mbc.E08-09-0934. Epub 2009 Jan 14.


Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting.

Chacinska A, van der Laan M, Mehnert CS, Guiard B, Mick DU, Hutu DP, Truscott KN, Wiedemann N, Meisinger C, Pfanner N, Rehling P.

Mol Cell Biol. 2010 Jan;30(1):307-18. doi: 10.1128/MCB.00749-09.


Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space.

Frazier AE, Chacinska A, Truscott KN, Guiard B, Pfanner N, Rehling P.

Mol Cell Biol. 2003 Nov;23(21):7818-28.


Interaction of Tim23 with Tim50 Is essential for protein translocation by the mitochondrial TIM23 complex.

Gevorkyan-Airapetov L, Zohary K, Popov-Celeketic D, Mapa K, Hell K, Neupert W, Azem A, Mokranjac D.

J Biol Chem. 2009 Feb 20;284(8):4865-72. doi: 10.1074/jbc.M807041200. Epub 2008 Nov 18.


Protein import into mitochondria.

Paschen SA, Neupert W.

IUBMB Life. 2001 Sep-Nov;52(3-5):101-12. Review.


Mitochondrial protein import. Requirement of presequence elements and tom components for precursor binding to the TOM complex.

Esaki M, Shimizu H, Ono T, Yamamoto H, Kanamori T, Nishikawa S, Endo T.

J Biol Chem. 2004 Oct 29;279(44):45701-7. Epub 2004 Aug 27.


Tim23 links the inner and outer mitochondrial membranes.

Donzeau M, Káldi K, Adam A, Paschen S, Wanner G, Guiard B, Bauer MF, Neupert W, Brunner M.

Cell. 2000 May 12;101(4):401-12.


Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase.

Hutu DP, Guiard B, Chacinska A, Becker D, Pfanner N, Rehling P, van der Laan M.

Mol Biol Cell. 2008 Jun;19(6):2642-9. doi: 10.1091/mbc.E07-12-1226. Epub 2008 Apr 9.


Protein translocation into mitochondria: the role of TIM complexes.

Bauer MF, Hofmann S, Neupert W, Brunner M.

Trends Cell Biol. 2000 Jan;10(1):25-31. Review.


The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44.

Dekker PJ, Martin F, Maarse AC, Bömer U, Müller H, Guiard B, Meijer M, Rassow J, Pfanner N.

EMBO J. 1997 Sep 1;16(17):5408-19.

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