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Items: 1 to 20 of 114

1.

APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.

Lynch JR, Tang W, Wang H, Vitek MP, Bennett ER, Sullivan PM, Warner DS, Laskowitz DT.

J Biol Chem. 2003 Dec 5;278(49):48529-33. Epub 2003 Sep 24.

2.

An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction.

Wang H, Durham L, Dawson H, Song P, Warner DS, Sullivan PM, Vitek MP, Laskowitz DT.

Neuroscience. 2007 Feb 23;144(4):1324-33. Epub 2006 Dec 20. Erratum in: Neuroscience. 2007 May 11;146(2):874.

PMID:
17187933
3.

Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis.

Li FQ, Sempowski GD, McKenna SE, Laskowitz DT, Colton CA, Vitek MP.

J Pharmacol Exp Ther. 2006 Sep;318(3):956-65. Epub 2006 Jun 1.

4.

Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.

Sheng H, Laskowitz DT, Bennett E, Schmechel DE, Bart RD, Saunders AM, Pearlstein RD, Roses AD, Warner DS.

J Cereb Blood Flow Metab. 1998 Apr;18(4):361-6.

PMID:
9538900
5.

A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity.

Guo L, LaDu MJ, Van Eldik LJ.

J Mol Neurosci. 2004;23(3):205-12.

PMID:
15181248
6.

A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage.

Gao J, Wang H, Sheng H, Lynch JR, Warner DS, Durham L, Vitek MP, Laskowitz DT.

Neurocrit Care. 2006;4(1):25-31.

PMID:
16498192
7.
8.

Apolipoprotein E suppresses the type I inflammatory response in vivo.

Ali K, Middleton M, Puré E, Rader DJ.

Circ Res. 2005 Oct 28;97(9):922-7. Epub 2005 Sep 22.

9.

Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content.

Han X, Cheng H, Fryer JD, Fagan AM, Holtzman DM.

J Biol Chem. 2003 Mar 7;278(10):8043-51. Epub 2002 Dec 24.

10.

Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior.

Grootendorst J, Bour A, Vogel E, Kelche C, Sullivan PM, Dodart JC, Bales K, Mathis C.

Behav Brain Res. 2005 Apr 15;159(1):1-14. Epub 2004 Nov 6.

PMID:
15794991
11.

Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.

Lynch JR, Morgan D, Mance J, Matthew WD, Laskowitz DT.

J Neuroimmunol. 2001 Mar 1;114(1-2):107-13.

PMID:
11240021
12.

Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures.

Aono M, Bennett ER, Kim KS, Lynch JR, Myers J, Pearlstein RD, Warner DS, Laskowitz DT.

Neuroscience. 2003;116(2):437-45.

PMID:
12559098
14.

Implications of apolipoprotein E genotype on inflammation and vitamin E status.

Huebbe P, Lodge JK, Rimbach G.

Mol Nutr Food Res. 2010 May;54(5):623-30. doi: 10.1002/mnfr.200900398. Review.

PMID:
20183830
15.

Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice.

Mori T, Kobayashi M, Town T, Fujita SC, Asano T.

J Neuropathol Exp Neurol. 2003 Mar;62(3):280-91.

PMID:
12638732
16.

Age-dependent cytokine responses: trimethyltin hippocampal injury in wild-type, APOE knockout, and APOE4 mice.

Harry GJ, Lefebvre d'Hellencourt C, Bruccoleri A, Schmechel D.

Brain Behav Immun. 2000 Dec;14(4):288-304.

PMID:
11120597
17.

Apoprotein E isoform-dependent expression and secretion of pro-inflammatory cytokines TNF-alpha and IL-6 in macrophages.

Tsoi LM, Wong KY, Liu YM, Ho YY.

Arch Biochem Biophys. 2007 Apr 1;460(1):33-40. Epub 2007 Feb 8.

PMID:
17353005
18.

Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.

Zhao L, Lin S, Bales KR, Gelfanova V, Koger D, Delong C, Hale J, Liu F, Hunter JM, Paul SM.

J Neurosci. 2009 Mar 18;29(11):3603-12. doi: 10.1523/JNEUROSCI.5302-08.2009.

19.

Effect of domain interaction on apolipoprotein E levels in mouse brain.

Ramaswamy G, Xu Q, Huang Y, Weisgraber KH.

J Neurosci. 2005 Nov 16;25(46):10658-63.

20.

Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: the allele E3 is neuroprotective whereas E4 increases fatalities.

Sabo T, Lomnitski L, Nyska A, Beni S, Maronpot RR, Shohami E, Roses AD, Michaelson DM.

Neuroscience. 2000;101(4):879-84.

PMID:
11113336

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