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Items: 1 to 20 of 97

1.

Overcoming the blood-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors.

Rice A, Michaelis ML, Georg G, Liu Y, Turunen B, Audus KL.

J Mol Neurosci. 2003;20(3):339-43.

PMID:
14501017
2.
3.

In situ blood-brain barrier permeability of a C-10 paclitaxel carbamate.

Ballatore C, Zhang B, Trojanowski JQ, Lee VM, Smith AB 3rd.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6119-21. doi: 10.1016/j.bmcl.2008.10.024. Epub 2008 Oct 10.

4.

A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro.

Cai P, Lu P, Sharom FJ, Fang WS.

Cancer Lett. 2013 Dec 1;341(2):214-23. doi: 10.1016/j.canlet.2013.08.010. Epub 2013 Aug 11.

PMID:
23941826
5.

Effect of Phoneutria nigriventer venom on the expression of junctional protein and P-gp efflux pump function in the blood-brain barrier.

Rapôso C, Odorissi PA, Oliveira AL, Aoyama H, Ferreira CV, Verinaud L, Fontana K, Ruela-de-Sousa RR, da Cruz-Höfling MA.

Neurochem Res. 2012 Sep;37(9):1967-81. doi: 10.1007/s11064-012-0817-y. Epub 2012 Jun 9.

PMID:
22684283
6.

Blood-brain barrier in vitro models as tools in drug discovery: assessment of the transport ranking of antihistaminic drugs.

Neuhaus W, Mandikova J, Pawlowitsch R, Linz B, Bennani-Baiti B, Lauer R, Lachmann B, Noe CR.

Pharmazie. 2012 May;67(5):432-9.

PMID:
22764578
7.

Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy.

Hoosain FG, Choonara YE, Tomar LK, Kumar P, Tyagi C, du Toit LC, Pillay V.

Biomed Res Int. 2015;2015:484963. doi: 10.1155/2015/484963. Epub 2015 Sep 27. Review.

8.

Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells.

Spletstoser JT, Turunen BJ, Desino K, Rice A, Datta A, Dutta D, Huff JK, Himes RH, Audus KL, Seelig A, Georg GI.

Bioorg Med Chem Lett. 2006 Feb;16(3):495-8. Epub 2005 Nov 10.

PMID:
16289636
9.

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies.

Brunden KR, Yao Y, Potuzak JS, Ferrer NI, Ballatore C, James MJ, Hogan AM, Trojanowski JQ, Smith AB 3rd, Lee VM.

Pharmacol Res. 2011 Apr;63(4):341-51. doi: 10.1016/j.phrs.2010.12.002. Epub 2010 Dec 14.

10.

Specific increase in MDR1 mediated drug-efflux in human brain endothelial cells following co-exposure to HIV-1 and saquinavir.

Roy U, Bulot C, Honer zu Bentrup K, Mondal D.

PLoS One. 2013 Oct 3;8(10):e75374. doi: 10.1371/journal.pone.0075374. eCollection 2013.

12.

Quantitative fluorescence microscopy provides high resolution imaging of passive diffusion and P-gp mediated efflux at the in vivo blood-brain barrier.

Mittapalli RK, Manda VK, Bohn KA, Adkins CE, Lockman PR.

J Neurosci Methods. 2013 Sep 30;219(1):188-95. doi: 10.1016/j.jneumeth.2013.07.001. Epub 2013 Aug 2.

13.

Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model.

Fan X, Chai L, Zhang H, Wang Y, Zhang B, Gao X.

Int J Mol Sci. 2015 Nov 18;16(11):27576-88. doi: 10.3390/ijms161126051.

14.

Brain-targeted delivery of paclitaxel using glutathione-coated nanoparticles for brain cancers.

Geldenhuys W, Mbimba T, Bui T, Harrison K, Sutariya V.

J Drug Target. 2011 Nov;19(9):837-45. doi: 10.3109/1061186X.2011.589435. Epub 2011 Jun 21.

PMID:
21692650
15.

The decrease of paclitaxel efflux by pretreatment of interferon-γ and tumor necrosis factor-α after intracerebral microinjection.

Lee NY, Kang YS.

Brain Res. 2013 Mar 7;1499:158-62. doi: 10.1016/j.brainres.2013.01.005. Epub 2013 Jan 9.

PMID:
23313612
16.

Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons.

Li G, Faibushevich A, Turunen BJ, Yoon SO, Georg G, Michaelis ML, Dobrowsky RT.

J Neurochem. 2003 Jan;84(2):347-62.

17.

Influence of time to achieve substrate distribution equilibrium between brain tissue and blood on quantitation of the blood-brain barrier P-glycoprotein effect.

Padowski JM, Pollack GM.

Brain Res. 2011 Dec 2;1426:1-17. doi: 10.1016/j.brainres.2011.10.009. Epub 2011 Oct 8.

PMID:
22036081
18.

Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both paracellular pathway and P-glycoprotein transportation.

Fang W, Lv P, Geng X, Shang E, Yang Q, Sha L, Li Y.

Neurochem Int. 2013 Jan;62(1):23-30. doi: 10.1016/j.neuint.2012.10.012. Epub 2012 Nov 8.

PMID:
23142723
19.
20.

Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier.

Emmert D, Campos CR, Ward D, Lu P, Namanja HA, Bohn K, Miller DS, Sharom FJ, Chmielewski J, Hrycyna CA.

ACS Chem Neurosci. 2014 Apr 16;5(4):305-17. doi: 10.1021/cn4002329. Epub 2014 Feb 7.

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