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Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5.

Hodder AN, Drew DR, Epa VC, Delorenzi M, Bourgon R, Miller SK, Moritz RL, Frecklington DF, Simpson RJ, Speed TP, Pike RN, Crabb BS.

J Biol Chem. 2003 Nov 28;278(48):48169-77. Epub 2003 Sep 17.


Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine.

Hodder AN, Malby RL, Clarke OB, Fairlie WD, Colman PM, Crabb BS, Smith BJ.

J Mol Biol. 2009 Sep 11;392(1):154-65. doi: 10.1016/j.jmb.2009.07.007. Epub 2009 Jul 8.


Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2.

Pandey KC, Sijwali PS, Singh A, Na BK, Rosenthal PJ.

J Biol Chem. 2004 Jan 30;279(5):3484-91. Epub 2003 Nov 18.


Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5.

Fairlie WD, Spurck TP, McCoubrie JE, Gilson PR, Miller SK, McFadden GI, Malby R, Crabb BS, Hodder AN.

Infect Immun. 2008 Sep;76(9):4332-44. doi: 10.1128/IAI.00278-08. Epub 2008 Jun 30.


Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: implications for vaccine and drug design.

McCoubrie JE, Miller SK, Sargeant T, Good RT, Hodder AN, Speed TP, de Koning-Ward TF, Crabb BS.

Infect Immun. 2007 Dec;75(12):5565-74. Epub 2007 Sep 24.


Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA5.

Tanabe K, Arisue N, Palacpac NM, Yagi M, Tougan T, Honma H, Ferreira MU, Färnert A, Björkman A, Kaneko A, Nakamura M, Hirayama K, Mita T, Horii T.

Vaccine. 2012 Feb 21;30(9):1583-93. doi: 10.1016/j.vaccine.2011.12.124. Epub 2012 Jan 9.


Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium.

Hansen G, Heitmann A, Witt T, Li H, Jiang H, Shen X, Heussler VT, Rennenberg A, Hilgenfeld R.

Structure. 2011 Jul 13;19(7):919-29. doi: 10.1016/j.str.2011.03.025.


Serine repeat antigen (SERA5) is predominantly expressed among the SERA multigene family of Plasmodium falciparum, and the acquired antibody titers correlate with serum inhibition of the parasite growth.

Aoki S, Li J, Itagaki S, Okech BA, Egwang TG, Matsuoka H, Palacpac NM, Mitamura T, Horii T.

J Biol Chem. 2002 Dec 6;277(49):47533-40. Epub 2002 Sep 18.


The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasite.

Putrianti ED, Schmidt-Christensen A, Arnold I, Heussler VT, Matuschewski K, Silvie O.

Cell Microbiol. 2010 Jun;12(6):725-39. doi: 10.1111/j.1462-5822.2009.01419.x. Epub 2009 Dec 21.


A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle.

Miller SK, Good RT, Drew DR, Delorenzi M, Sanders PR, Hodder AN, Speed TP, Cowman AF, de Koning-Ward TF, Crabb BS.

J Biol Chem. 2002 Dec 6;277(49):47524-32. Epub 2002 Sep 11.


The serine repeat antigen (SERA) gene family phylogeny in Plasmodium: the impact of GC content and reconciliation of gene and species trees.

Bourgon R, Delorenzi M, Sargeant T, Hodder AN, Crabb BS, Speed TP.

Mol Biol Evol. 2004 Nov;21(11):2161-71. Epub 2004 Aug 11.


Cysteine proteases of malaria parasites.

Rosenthal PJ.

Int J Parasitol. 2004 Dec;34(13-14):1489-99. Review.


Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling.

Withers-Martinez C, Saldanha JW, Ely B, Hackett F, O'Connor T, Blackman MJ.

J Biol Chem. 2002 Aug 16;277(33):29698-709. Epub 2002 Jun 6.


Genetic and structural characterization of PvSERA4: potential implication as therapeutic target for Plasmodium vivax malaria.

Rahul CN, Shiva Krishna K, Pawar AP, Bai M, Kumar V, Phadke S, Rajesh V.

J Biomol Struct Dyn. 2014 Apr;32(4):580-90. doi: 10.1080/07391102.2013.782824. Epub 2013 Apr 13.


Antibodies elicited by a virosomally formulated Plasmodium falciparum serine repeat antigen-5 derived peptide detect the processed 47 kDa fragment both in sporozoites and merozoites.

Okitsu SL, Boato F, Mueller MS, Li DB, Vogel D, Westerfeld N, Zurbriggen R, Robinson JA, Pluschke G.

Peptides. 2007 Oct;28(10):2051-60. Epub 2007 Aug 17.


Exploring the role of putative active site amino acids and pro-region motif of recombinant falcipain-2: a principal hemoglobinase of Plasmodium falciparum.

Kumar A, Dasaradhi PV, Chauhan VS, Malhotra P.

Biochem Biophys Res Commun. 2004 Apr 23;317(1):38-45.


Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights.

Gengenbacher M, Fitzpatrick TB, Raschle T, Flicker K, Sinning I, Müller S, Macheroux P, Tews I, Kappes B.

J Biol Chem. 2006 Feb 10;281(6):3633-41. Epub 2005 Dec 8.


Structural and functional characterization of Falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum.

Hogg T, Nagarajan K, Herzberg S, Chen L, Shen X, Jiang H, Wecke M, Blohmke C, Hilgenfeld R, Schmidt CL.

J Biol Chem. 2006 Sep 1;281(35):25425-37. Epub 2006 Jun 15.


Structural basis of the unusual stability and substrate specificity of ervatamin C, a plant cysteine protease from Ervatamia coronaria.

Thakurta PG, Biswas S, Chakrabarti C, Sundd M, Jagannadham MV, Dattagupta JK.

Biochemistry. 2004 Feb 17;43(6):1532-40.


Plasmodium falciparum serine-repeat antigen (SERA) forms a homodimer through disulfide bond.

Sato D, Li J, Mitamura T, Horii T.

Parasitol Int. 2005 Dec;54(4):261-5.


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