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Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.

Hirsch FR, Varella-Garcia M, Bunn PA Jr, Di Maria MV, Veve R, Bremmes RM, Barón AE, Zeng C, Franklin WA.

J Clin Oncol. 2003 Oct 15;21(20):3798-807. Epub 2003 Sep 2.


Clinicopathologic features and prognostic implications of epidermal growth factor receptor (EGFR) gene copy number and protein expression in non-small cell lung cancer.

Jeon YK, Sung SW, Chung JH, Park WS, Seo JW, Kim CW, Chung DH.

Lung Cancer. 2006 Dec;54(3):387-98. Epub 2006 Sep 29.


Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study.

Hirsch FR, Varella-Garcia M, McCoy J, West H, Xavier AC, Gumerlock P, Bunn PA Jr, Franklin WA, Crowley J, Gandara DR; Southwest Oncology Group.

J Clin Oncol. 2005 Oct 1;23(28):6838-45. Epub 2005 Jul 5.


Validation of chromogenic in situ hybridization for detection of EGFR copy number amplification in nonsmall cell lung carcinoma.

Sholl LM, John Iafrate A, Chou YP, Wu MT, Goan YG, Su L, Huang YT, Christiani DC, Chirieac LR.

Mod Pathol. 2007 Oct;20(10):1028-35. Epub 2007 Aug 3.


Protein overexpression and gene amplification of epidermal growth factor receptor in nonsmall cell lung carcinomas: Comparison of four commercially available antibodies by immunohistochemistry and fluorescence in situ hybridization study.

Lee HJ, Xu X, Choe G, Chung DH, Seo JW, Lee JH, Lee CT, Jheon S, Sung SW, Chung JH.

Lung Cancer. 2010 Jun;68(3):375-82. doi: 10.1016/j.lungcan.2009.07.014. Epub 2009 Aug 26.


Association between epidermal growth factor receptor gene copy number and ERCC1, BRCA1 protein expression in Chinese patients with non-small cell lung cancer.

Zhang Y, Yang H, Qiu Y, Deng Q, Liu J, Zhao M, He P, Mo M, Zou X, He J.

Med Oncol. 2014 Mar;31(3):803. doi: 10.1007/s12032-013-0803-5. Epub 2014 Jan 23.


Chromogenic in situ hybridization to detect EGFR gene copy number in cell blocks from fine-needle aspirates of non small cell lung carcinomas and lung metastases from colo-rectal cancer.

Simone G, Mangia A, Malfettone A, Rubini V, Siciliano M, Di Benedetto A, Terrenato I, Novelli F, Mottolese M.

J Exp Clin Cancer Res. 2010 Sep 15;29:125. doi: 10.1186/1756-9966-29-125.


Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: a comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression.

Dziadziuszko R, Merrick DT, Witta SE, Mendoza AD, Szostakiewicz B, Szymanowska A, Rzyman W, Dziadziuszko K, Jassem J, Bunn PA Jr, Varella-Garcia M, Hirsch FR.

J Clin Oncol. 2010 May 1;28(13):2174-80. doi: 10.1200/JCO.2009.24.6611. Epub 2010 Mar 29.


Epidermal growth factor receptor gene amplification in surgical resected Japanese lung cancer.

Sasaki H, Shimizu S, Okuda K, Kawano O, Yukiue H, Yano M, Fujii Y.

Lung Cancer. 2009 Jun;64(3):295-300. doi: 10.1016/j.lungcan.2008.10.005. Epub 2008 Dec 5.


Increased ALK gene copy number and amplification are frequent in non-small cell lung cancer.

Salido M, Pijuan L, Martínez-Avilés L, Galván AB, Cañadas I, Rovira A, Zanui M, Martínez A, Longarón R, Sole F, Serrano S, Bellosillo B, Wynes MW, Albanell J, Hirsch FR, Arriola E.

J Thorac Oncol. 2011 Jan;6(1):21-7. doi: 10.1097/JTO.0b013e3181fb7cd6.


Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients.

Cappuzzo F, Varella-Garcia M, Shigematsu H, Domenichini I, Bartolini S, Ceresoli GL, Rossi E, Ludovini V, Gregorc V, Toschi L, Franklin WA, Crino L, Gazdar AF, Bunn PA Jr, Hirsch FR.

J Clin Oncol. 2005 Aug 1;23(22):5007-18.


EGFR expression and copy number changes in low T-stage oral squamous cell carcinomas.

Rössle M, Weber CS, Züllig L, Graf N, Jochum W, Stöckli SJ, Moch H, Huber GF.

Histopathology. 2013 Aug;63(2):271-8. doi: 10.1111/his.12175. Epub 2013 Jun 13.


Significance of EGFR protein expression and gene amplification in non-small cell lung carcinoma.

Dacic S, Flanagan M, Cieply K, Ramalingam S, Luketich J, Belani C, Yousem SA.

Am J Clin Pathol. 2006 Jun;125(6):860-5.


Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: a chromogenic in situ hybridization study of 182 patients.

Chang JW, Liu HP, Hsieh MH, Fang YF, Hsieh MS, Hsieh JJ, Chiu YT, Tsai HY, Chen YH, Chen YT, Hsu HY, Chen YT, Tsai SF, Chen YR, Hsi BL, Huang SF.

Lung Cancer. 2008 Sep;61(3):328-39. doi: 10.1016/j.lungcan.2008.01.009. Epub 2008 Mar 4.


MET gene copy number in non-small cell lung cancer: molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort.

Beau-Faller M, Ruppert AM, Voegeli AC, Neuville A, Meyer N, Guerin E, Legrain M, Mennecier B, Wihlm JM, Massard G, Quoix E, Oudet P, Gaub MP.

J Thorac Oncol. 2008 Apr;3(4):331-9. doi: 10.1097/JTO.0b013e318168d9d4.


Clinical significance of epidermal growth factor receptors in non-small cell lung cancer and a prognostic role for HER2 gene copy number in female patients.

Al-Saad S, Al-Shibli K, Donnem T, Andersen S, Bremnes RM, Busund LT.

J Thorac Oncol. 2010 Oct;5(10):1536-43. doi: 10.1097/JTO.0b013e3181ea510a.


Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patients.

Liang Z, Zeng X, Gao J, Wu S, Wang P, Shi X, Zhang J, Liu T.

BMC Cancer. 2008 Dec 6;8:363. doi: 10.1186/1471-2407-8-363.

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