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CpG content affects gene silencing in mice: evidence from novel transgenes.

Chevalier-Mariette C, Henry I, Montfort L, Capgras S, Forlani S, Muschler J, Nicolas JF.

Genome Biol. 2003;4(9):R53. Epub 2003 Aug 14.


A novel imprinted transgene located near a repetitive element that exhibits allelic imbalance in DNA methylation during early development.

Uchiyama K, Watanabe D, Hayasaka M, Hanaoka K.

Dev Growth Differ. 2014 Dec;56(9):653-68. doi: 10.1111/dgd.12182. Epub 2014 Nov 11.


Interplay of Promoter Usage and Intragenic CpG Content: Impact on GFP Reporter Gene Expression.

Krinner S, Heitzer A, Asbach B, Wagner R.

Hum Gene Ther. 2015 Dec;26(12):826-40. doi: 10.1089/hum.2015.075. Epub 2015 Sep 29.


Pre-selection of integration sites imparts repeatable transgene expression.

Wallace H, Ansell R, Clark J, McWhir J.

Nucleic Acids Res. 2000 Mar 15;28(6):1455-64.


Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.

Yuan J, Luo RZ, Fujii S, Wang L, Hu W, Andreeff M, Pan Y, Kadota M, Oshimura M, Sahin AA, Issa JP, Bast RC Jr, Yu Y.

Cancer Res. 2003 Jul 15;63(14):4174-80.


DNA methylation of Sleeping Beauty with transposition into the mouse genome.

Park CW, Kren BT, Largaespada DA, Steer CJ.

Genes Cells. 2005 Aug;10(8):763-76.


DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter.

Han H, Cortez CC, Yang X, Nichols PW, Jones PA, Liang G.

Hum Mol Genet. 2011 Nov 15;20(22):4299-310. doi: 10.1093/hmg/ddr356. Epub 2011 Aug 11.


CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells.

Opavsky R, Wang SH, Trikha P, Raval A, Huang Y, Wu YZ, Rodriguez B, Keller B, Liyanarachchi S, Wei G, Davuluri RV, Weinstein M, Felsher D, Ostrowski M, Leone G, Plass C.

PLoS Genet. 2007 Sep;3(9):1757-69. Epub 2007 Aug 16.


Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation.

Chen ZY, Riu E, He CY, Xu H, Kay MA.

Mol Ther. 2008 Mar;16(3):548-56. doi: 10.1038/ Epub 2008 Feb 5.


Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation.

Kirov JV, Adkisson M, Nava AJ, Cipollone A, Willis B, Engelhard EK, Lloyd KC, de Jong P, West DB.

PLoS One. 2015 Aug 14;10(8):e0134155. doi: 10.1371/journal.pone.0134155. eCollection 2015.


lacZ sequences prevent regulated expression of housekeeping genes.

Cohen-Tannoudji M, Vandormael-Pournin S, Drezen J, Mercier P, Babinet C, Morello D.

Mech Dev. 2000 Jan;90(1):29-39.


Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent.

Müller C, Readhead C, Diederichs S, Idos G, Yang R, Tidow N, Serve H, Berdel WE, Koeffler HP.

Mol Cell Biol. 2000 May;20(9):3316-29.


Predicting aberrant CpG island methylation.

Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12253-8. Epub 2003 Sep 30.


Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression.

Mitsui M, Nishikawa M, Zang L, Ando M, Hattori K, Takahashi Y, Watanabe Y, Takakura Y.

J Gene Med. 2009 May;11(5):435-43. doi: 10.1002/jgm.1317.


Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island.

Zhang Y, Shu J, Si J, Shen L, Estecio MR, Issa JP.

Nucleic Acids Res. 2012 Aug;40(15):7257-68. Epub 2012 May 17.

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