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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

Wei H, Ahn S, Shenoy SK, Karnik SS, Hunyady L, Luttrell LM, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10782-7. Epub 2003 Aug 29.


Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ.

J Biol Chem. 2006 Apr 21;281(16):10856-64. Epub 2006 Feb 21.


Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis.

Hunton DL, Barnes WG, Kim J, Ren XR, Violin JD, Reiter E, Milligan G, Patel DD, Lefkowitz RJ.

Mol Pharmacol. 2005 Apr;67(4):1229-36. Epub 2005 Jan 5.


beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ.

J Biol Chem. 2006 Jan 13;281(2):1261-73. Epub 2005 Nov 9.


The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network.

Kendall RT, Strungs EG, Rachidi SM, Lee MH, El-Shewy HM, Luttrell DK, Janech MG, Luttrell LM.

J Biol Chem. 2011 Jun 3;286(22):19880-91. doi: 10.1074/jbc.M111.233080. Epub 2011 Apr 18.


Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.

Ahn S, Shenoy SK, Wei H, Lefkowitz RJ.

J Biol Chem. 2004 Aug 20;279(34):35518-25. Epub 2004 Jun 17.


beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.

Tohgo A, Pierce KL, Choy EW, Lefkowitz RJ, Luttrell LM.

J Biol Chem. 2002 Mar 15;277(11):9429-36. Epub 2002 Jan 2.


Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription.

Lee MH, El-Shewy HM, Luttrell DK, Luttrell LM.

J Biol Chem. 2008 Jan 25;283(4):2088-97. Epub 2007 Nov 15.


beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.

Barnes WG, Reiter E, Violin JD, Ren XR, Milligan G, Lefkowitz RJ.

J Biol Chem. 2005 Mar 4;280(9):8041-50. Epub 2004 Dec 16.


Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.

Ahn S, Wei H, Garrison TR, Lefkowitz RJ.

J Biol Chem. 2004 Feb 27;279(9):7807-11. Epub 2004 Jan 7.


beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.

DeFea KA, Zalevsky J, Thoma MS, Déry O, Mullins RD, Bunnett NW.

J Cell Biol. 2000 Mar 20;148(6):1267-81.


beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.

Gesty-Palmer D, El Shewy H, Kohout TA, Luttrell LM.

J Biol Chem. 2005 Sep 16;280(37):32157-67. Epub 2005 Jul 15.


Angiotensin II-stimulated signaling through G proteins and beta-arrestin.

Shenoy SK, Lefkowitz RJ.

Sci STKE. 2005 Nov 22;2005(311):cm14.


The three α1-adrenoceptor subtypes show different spatio-temporal mechanisms of internalization and ERK1/2 phosphorylation.

Perez-Aso M, Segura V, Montó F, Barettino D, Noguera MA, Milligan G, D'Ocon P.

Biochim Biophys Acta. 2013 Oct;1833(10):2322-33. doi: 10.1016/j.bbamcr.2013.06.013. Epub 2013 Jun 21.


Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.

Ren XR, Reiter E, Ahn S, Kim J, Chen W, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1448-53. Epub 2005 Jan 25.


Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

Paradis JS, Ly S, Blondel-Tepaz É, Galan JA, Beautrait A, Scott MG, Enslen H, Marullo S, Roux PP, Bouvier M.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5160-8. doi: 10.1073/pnas.1508836112. Epub 2015 Aug 31.


Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.

McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ.

Science. 2000 Nov 24;290(5496):1574-7.

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