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Items: 1 to 20 of 266

1.

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.

Nature. 2003 Sep 11;425(6954):191-6. Epub 2003 Aug 24.

PMID:
12939617
2.

Ageing: a toast to long life.

Finkel T.

Nature. 2003 Sep 11;425(6954):132-3. No abstract available.

PMID:
12968159
3.

Longevity research. In vino vitalis? Compounds activate life-extending genes.

Hall SS.

Science. 2003 Aug 29;301(5637):1165. No abstract available.

PMID:
12947168
4.

Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.

Tsuchiya M, Dang N, Kerr EO, Hu D, Steffen KK, Oakes JA, Kennedy BK, Kaeberlein M.

Aging Cell. 2006 Dec;5(6):505-14.

PMID:
17129213
5.

Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D.

Nature. 2004 Aug 5;430(7000):686-9. Epub 2004 Jul 14. Erratum in: Nature. 2004 Sep 2;431(7004):107.

PMID:
15254550
6.

Small molecules that regulate lifespan: evidence for xenohormesis.

Lamming DW, Wood JG, Sinclair DA.

Mol Microbiol. 2004 Aug;53(4):1003-9. Review.

PMID:
15306006
7.

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.

Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA.

Nature. 2003 May 8;423(6936):181-5.

PMID:
12736687
8.

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA.

J Biol Chem. 2002 Nov 22;277(47):45099-107. Epub 2002 Sep 23.

PMID:
12297502
9.

Human Sir2 and the 'silencing' of p53 activity.

Smith J.

Trends Cell Biol. 2002 Sep;12(9):404-6.

PMID:
12220851
10.

Substrate-specific activation of sirtuins by resveratrol.

Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK.

J Biol Chem. 2005 Apr 29;280(17):17038-45. Epub 2005 Jan 31.

PMID:
15684413
11.

Does resveratrol activate yeast Sir2 in vivo?

Kaeberlein M, Kennedy BK.

Aging Cell. 2007 Aug;6(4):415-6. No abstract available.

PMID:
17635418
12.

The Sir2 family of protein deacetylases.

Blander G, Guarente L.

Annu Rev Biochem. 2004;73:417-35. Review.

PMID:
15189148
13.

Dietary activators of Sirt1.

Allard JS, Perez E, Zou S, de Cabo R.

Mol Cell Endocrinol. 2009 Feb 5;299(1):58-63. doi: 10.1016/j.mce.2008.10.018. Epub 2008 Nov 1. Review.

PMID:
19010386
14.

A novel assay for replicative lifespan in Saccharomyces cerevisiae.

Jarolim S, Millen J, Heeren G, Laun P, Goldfarb DS, Breitenbach M.

FEMS Yeast Res. 2004 Nov;5(2):169-77.

PMID:
15489200
15.

SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates.

Sauve AA, Schramm VL.

Curr Med Chem. 2004 Apr;11(7):807-26. Review.

PMID:
15078167
16.

Yeast life-span extension by calorie restriction is independent of NAD fluctuation.

Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA.

Science. 2003 Dec 19;302(5653):2124-2126. doi: 10.1126/science.1088697. Epub 2003 Nov 6.

PMID:
14605207
17.

Scientific community. Aging research's family feud.

Couzin J.

Science. 2004 Feb 27;303(5662):1276-9. No abstract available.

PMID:
14988530
18.

Design and synthesis of compounds that extend yeast replicative lifespan.

Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA.

Aging Cell. 2007 Feb;6(1):35-43. Epub 2006 Dec 5. Erratum in: Aging Cell. 2007 Aug;6(4):593. Adams, Jeffrey K [added]; Kisielewski, Anne [added]; Howitz, Konrad T [added]; Zipkin, Robert E [added].

PMID:
17156081
19.

Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins.

Smith DL Jr, McClure JM, Matecic M, Smith JS.

Aging Cell. 2007 Oct;6(5):649-62. Epub 2007 Aug 15.

PMID:
17711561
20.

HST2 mediates SIR2-independent life-span extension by calorie restriction.

Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA.

Science. 2005 Sep 16;309(5742):1861-4. Epub 2005 Jul 28.

PMID:
16051752

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