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Items: 1 to 20 of 316


Blocking the function of tyrosine phosphatase SHP-2 by targeting its Src homology 2 domains.

Zhao R, Fu X, Teng L, Li Q, Zhao ZJ.

J Biol Chem. 2003 Oct 31;278(44):42893-8. Epub 2003 Aug 11.


The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation.

Huang Q, Lerner-Marmarosh N, Che W, Ohta S, Osawa M, Yoshizumi M, Glassman M, Yan C, Berk BC, Abe J.

J Biol Chem. 2002 Aug 9;277(32):29330-41. Epub 2002 May 14. Erratum in: J Biol Chem. 2003 May 23;278(21):19574.


The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.

Godeny MD, Sayyah J, VonDerLinden D, Johns M, Ostrov DA, Caldwell-Busby J, Sayeski PP.

Cell Signal. 2007 Mar;19(3):600-9. Epub 2006 Sep 1.


Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation.

Takada T, Matozaki T, Takeda H, Fukunaga K, Noguchi T, Fujioka Y, Okazaki I, Tsuda M, Yamao T, Ochi F, Kasuga M.

J Biol Chem. 1998 Apr 10;273(15):9234-42.


The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.

Kolli S, Zito CI, Mossink MH, Wiemer EA, Bennett AM.

J Biol Chem. 2004 Jul 9;279(28):29374-85. Epub 2004 May 7.


Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2.

Arnaud M, Mzali R, Gesbert F, Crouin C, Guenzi C, Vermot-Desroches C, Wijdenes J, Courtois G, Bernard O, Bertoglio J.

Biochem J. 2004 Sep 1;382(Pt 2):545-56.


Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling.

Zhao R, Guerrah A, Tang H, Zhao ZJ.

J Biol Chem. 2002 Mar 8;277(10):7882-8. Epub 2001 Dec 20.


PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.

Okazaki T, Maeda A, Nishimura H, Kurosaki T, Honjo T.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13866-71. Epub 2001 Nov 6.


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