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Items: 1 to 20 of 178

1.

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling.

Weber AN, Tauszig-Delamasure S, Hoffmann JA, Lelièvre E, Gascan H, Ray KP, Morse MA, Imler JL, Gay NJ.

Nat Immunol. 2003 Aug;4(8):794-800. Epub 2003 Jul 20.

PMID:
12872120
2.

Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway.

Weber AN, Moncrieffe MC, Gangloff M, Imler JL, Gay NJ.

J Biol Chem. 2005 Jun 17;280(24):22793-9. Epub 2005 Mar 28.

3.

A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity.

Jang IH, Chosa N, Kim SH, Nam HJ, Lemaitre B, Ochiai M, Kambris Z, Brun S, Hashimoto C, Ashida M, Brey PT, Lee WJ.

Dev Cell. 2006 Jan;10(1):45-55.

4.
5.

Evolutionary and functional epitopes of the Spätzle protein: new insights into activation of the Toll receptor.

Wang Y, Zhu S.

Cell Mol Life Sci. 2009 May;66(9):1595-602. doi: 10.1007/s00018-009-9028-3.

PMID:
19308321
6.

A three-step proteolytic cascade mediates the activation of the peptidoglycan-induced toll pathway in an insect.

Kim CH, Kim SJ, Kan H, Kwon HM, Roh KB, Jiang R, Yang Y, Park JW, Lee HH, Ha NC, Kang HJ, Nonaka M, Söderhäll K, Lee BL.

J Biol Chem. 2008 Mar 21;283(12):7599-607. doi: 10.1074/jbc.M710216200. Epub 2008 Jan 14.

7.

Formation and biochemical characterization of tube/pelle death domain complexes: critical regulators of postreceptor signaling by the Drosophila toll receptor.

Schiffmann DA, White JH, Cooper A, Nutley MA, Harding SE, Jumel K, Solari R, Ray KP, Gay NJ.

Biochemistry. 1999 Sep 7;38(36):11722-33.

PMID:
10512628
9.

Evolutionary relationships, but functional differences, between the Drosophila and human Toll-like receptor families.

Gangloff M, Weber AN, Gibbard RJ, Gay NJ.

Biochem Soc Trans. 2003 Jun;31(Pt 3):659-63. Review.

PMID:
12773177
10.

Proteolytic cascade for the activation of the insect toll pathway induced by the fungal cell wall component.

Roh KB, Kim CH, Lee H, Kwon HM, Park JW, Ryu JH, Kurokawa K, Ha NC, Lee WJ, Lemaitre B, Söderhäll K, Lee BL.

J Biol Chem. 2009 Jul 17;284(29):19474-81. doi: 10.1074/jbc.M109.007419. Epub 2009 May 27.

11.

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults.

Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA.

Cell. 1996 Sep 20;86(6):973-83.

12.

High level expression of the Drosophila Toll receptor ectodomain and crystallization of its complex with the morphogen Spätzle.

Stelter M, Fandrich U, Franzke K, Schierhorn A, Breithaupt C, Parthier C, Stubbs MT.

Biol Chem. 2013 Aug;394(8):1091-6. doi: 10.1515/hsz-2013-0136.

PMID:
23729564
13.

Activation of Drosophila Toll during fungal infection by a blood serine protease.

Ligoxygakis P, Pelte N, Hoffmann JA, Reichhart JM.

Science. 2002 Jul 5;297(5578):114-6.

14.

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein.

Michel T, Reichhart JM, Hoffmann JA, Royet J.

Nature. 2001 Dec 13;414(6865):756-9.

PMID:
11742401
15.

In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila.

Nicolas E, Reichhart JM, Hoffmann JA, Lemaitre B.

J Biol Chem. 1998 Apr 24;273(17):10463-9.

16.

Toll signaling pathways in the innate immune response.

Anderson KV.

Curr Opin Immunol. 2000 Feb;12(1):13-9. Review.

PMID:
10679407
17.

A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo.

Schneider DS, Jin Y, Morisato D, Anderson KV.

Development. 1994 May;120(5):1243-50.

18.

Toll gets tied in a knot.

Underhill D.

Nat Immunol. 2003 Aug;4(8):723-4. No abstract available.

PMID:
12888789
19.
20.

Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity.

Parthier C, Stelter M, Ursel C, Fandrich U, Lilie H, Breithaupt C, Stubbs MT.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6281-6. doi: 10.1073/pnas.1320678111. Epub 2014 Apr 14.

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