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Items: 1 to 20 of 456

1.

Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes.

Nakaoka Y, Nishida K, Fujio Y, Izumi M, Terai K, Oshima Y, Sugiyama S, Matsuda S, Koyasu S, Yamauchi-Takihara K, Hirano T, Kawase I, Hirota H.

Circ Res. 2003 Aug 8;93(3):221-9. Epub 2003 Jul 10.

2.

SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene.

Nakaoka Y, Shioyama W, Kunimoto S, Arita Y, Higuchi K, Yamamoto K, Fujio Y, Nishida K, Kuroda T, Hirota H, Yamauchi-Takihara K, Hirano T, Komuro I, Mochizuki N.

J Mol Cell Cardiol. 2010 Aug;49(2):157-64. doi: 10.1016/j.yjmcc.2010.03.001. Epub 2010 Mar 11.

PMID:
20226789
3.

Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes.

Kunisada K, Tone E, Fujio Y, Matsui H, Yamauchi-Takihara K, Kishimoto T.

Circulation. 1998 Jul 28;98(4):346-52.

4.

TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex.

Bode JG, Schweigart J, Kehrmann J, Ehlting C, Schaper F, Heinrich PC, Häussinger D.

J Immunol. 2003 Jul 1;171(1):257-66.

5.

Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation.

Anhuf D, Weissenbach M, Schmitz J, Sobota R, Hermanns HM, Radtke S, Linnemann S, Behrmann I, Heinrich PC, Schaper F.

J Immunol. 2000 Sep 1;165(5):2535-43.

7.

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase.

Takahashi-Tezuka M, Yoshida Y, Fukada T, Ohtani T, Yamanaka Y, Nishida K, Nakajima K, Hibi M, Hirano T.

Mol Cell Biol. 1998 Jul;18(7):4109-17.

8.

Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.

Nishida K, Yoshida Y, Itoh M, Fukada T, Ohtani T, Shirogane T, Atsumi T, Takahashi-Tezuka M, Ishihara K, Hibi M, Hirano T.

Blood. 1999 Mar 15;93(6):1809-16.

9.

The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase.

Ingham RJ, Santos L, Dang-Lawson M, Holgado-Madruga M, Dudek P, Maroun CR, Wong AJ, Matsuuchi L, Gold MR.

J Biol Chem. 2001 Apr 13;276(15):12257-65. Epub 2001 Jan 22.

10.

Gab1, SHP2, and protein kinase A are crucial for the activation of the endothelial NO synthase by fluid shear stress.

Dixit M, Loot AE, Mohamed A, Fisslthaler B, Boulanger CM, Ceacareanu B, Hassid A, Busse R, Fleming I.

Circ Res. 2005 Dec 9;97(12):1236-44. Epub 2005 Nov 10.

11.
12.

Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes.

Fujio Y, Kunisada K, Hirota H, Yamauchi-Takihara K, Kishimoto T.

J Clin Invest. 1997 Jun 15;99(12):2898-905.

13.
14.

ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.

Yu CF, Liu ZX, Cantley LG.

J Biol Chem. 2002 May 31;277(22):19382-8. Epub 2002 Mar 14.

15.

A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation.

Montagner A, Yart A, Dance M, Perret B, Salles JP, Raynal P.

J Biol Chem. 2005 Feb 18;280(7):5350-60. Epub 2004 Dec 1.

17.

Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation.

Holgado-Madruga M, Wong AJ.

Cancer Res. 2004 Mar 15;64(6):2007-15.

18.

Regulation of neuregulin-mediated acetylcholine receptor synthesis by protein tyrosine phosphatase SHP2.

Tanowitz M, Si J, Yu DH, Feng GS, Mei L.

J Neurosci. 1999 Nov 1;19(21):9426-35.

19.
20.

Significance of ERK cascade compared with JAK/STAT and PI3-K pathway in gp130-mediated cardiac hypertrophy.

Kodama H, Fukuda K, Pan J, Sano M, Takahashi T, Kato T, Makino S, Manabe T, Murata M, Ogawa S.

Am J Physiol Heart Circ Physiol. 2000 Oct;279(4):H1635-44.

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