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The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.

Basler CF, Mikulasova A, Martinez-Sobrido L, Paragas J, Mühlberger E, Bray M, Klenk HD, Palese P, García-Sastre A.

J Virol. 2003 Jul;77(14):7945-56.


The Ebola virus VP35 protein functions as a type I IFN antagonist.

Basler CF, Wang X, Mühlberger E, Volchkov V, Paragas J, Klenk HD, García-Sastre A, Palese P.

Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12289-94.


Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling.

Cárdenas WB, Loo YM, Gale M Jr, Hartman AL, Kimberlin CR, Martínez-Sobrido L, Saphire EO, Basler CF.

J Virol. 2006 Jun;80(11):5168-78.


Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

Servant MJ, Grandvaux N, tenOever BR, Duguay D, Lin R, Hiscott J.

J Biol Chem. 2003 Mar 14;278(11):9441-7. Epub 2003 Jan 10.


The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activation.

Donelan NR, Dauber B, Wang X, Basler CF, Wolff T, García-Sastre A.

J Virol. 2004 Nov;78(21):11574-82.


Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein.

Talon J, Horvath CM, Polley R, Basler CF, Muster T, Palese P, García-Sastre A.

J Virol. 2000 Sep;74(17):7989-96.


Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.

Prins KC, Cárdenas WB, Basler CF.

J Virol. 2009 Apr;83(7):3069-77. doi: 10.1128/JVI.01875-08. Epub 2009 Jan 19.


Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3.

Spiegel M, Pichlmair A, Martínez-Sobrido L, Cros J, García-Sastre A, Haller O, Weber F.

J Virol. 2005 Feb;79(4):2079-86.


Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virus.

Hartman AL, Bird BH, Towner JS, Antoniadou ZA, Zaki SR, Nichol ST.

J Virol. 2008 Mar;82(6):2699-704. doi: 10.1128/JVI.02344-07. Epub 2008 Jan 16.


Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.

Lin R, Heylbroeck C, Genin P, Pitha PM, Hiscott J.

Mol Cell Biol. 1999 Feb;19(2):959-66.


Evasion of interferon responses by Ebola and Marburg viruses.

Basler CF, Amarasinghe GK.

J Interferon Cytokine Res. 2009 Sep;29(9):511-20. doi: 10.1089/jir.2009.0076. Review.


Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.

Civas A, Génin P, Morin P, Lin R, Hiscott J.

J Biol Chem. 2006 Feb 24;281(8):4856-66. Epub 2005 Dec 27.


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