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Items: 1 to 20 of 128

1.

NAALADase inhibition protects motor neurons against chronic glutamate toxicity.

Thomas AG, Corse AM, Coccia CF, Bilak MM, Rothstein JD, Slusher BS.

Eur J Pharmacol. 2003 Jun 27;471(3):177-84.

PMID:
12826236
2.

Neuroprotection produced by the NAALADase inhibitor 2-PMPA in rat cerebellar neurons.

Tortella FC, Lin Y, Ved H, Slusher BS, Dave JR.

Eur J Pharmacol. 2000 Aug 18;402(1-2):31-7.

PMID:
10940354
3.

Inhibition of glutamate carboxypeptidase II (NAALADase) protects against dynorphin A-induced ischemic spinal cord injury in rats.

Long JB, Yourick DL, Slusher BS, Robinson MB, Meyerhoff JL.

Eur J Pharmacol. 2005 Jan 31;508(1-3):115-22. Epub 2005 Jan 7.

PMID:
15680261
4.

Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta.

Thomas AG, Liu W, Olkowski JL, Tang Z, Lin Q, Lu XC, Slusher BS.

Eur J Pharmacol. 2001 Oct 26;430(1):33-40.

PMID:
11698060
5.

N-acetylated-alpha-linked-acidic dipeptidase inhibitor has a neuroprotective effect on mouse retinal ganglion cells after pressure-induced ischemia.

Harada C, Harada T, Slusher BS, Yoshida K, Matsuda H, Wada K.

Neurosci Lett. 2000 Oct 6;292(2):134-6.

PMID:
10998567
6.

Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration.

Bilak MM, Corse AM, Bilak SR, Lehar M, Tombran-Tink J, Kuncl RW.

J Neuropathol Exp Neurol. 1999 Jul;58(7):719-28.

PMID:
10411342
7.

Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury.

Slusher BS, Vornov JJ, Thomas AG, Hurn PD, Harukuni I, Bhardwaj A, Traystman RJ, Robinson MB, Britton P, Lu XC, Tortella FC, Wozniak KM, Yudkoff M, Potter BM, Jackson PF.

Nat Med. 1999 Dec;5(12):1396-402.

PMID:
10581082
9.
10.

Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity.

Rothstein JD, Kuncl RW.

J Neurochem. 1995 Aug;65(2):643-51.

PMID:
7616220
11.

Blockade of NAALADase: a novel neuroprotective strategy based on limiting glutamate and elevating NAAG.

Vornov JJ, Wozniak K, Lu M, Jackson P, Tsukamoto T, Wang E, Slusher B.

Ann N Y Acad Sci. 1999;890:400-5.

PMID:
10668445
12.

Binding of the glutamate carboxypeptidase II (NAALADase) inhibitor 2-PMPA to rat brain membranes.

Tiffany CW, Cai NS, Rojas C, Slusher BS.

Eur J Pharmacol. 2001 Sep 14;427(2):91-6.

PMID:
11557259
13.

Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA).

Rais R, Rojas C, Wozniak K, Wu Y, Zhao M, Tsukamoto T, Rudek MA, Slusher BS.

J Pharm Biomed Anal. 2014 Jan;88:162-9. doi: 10.1016/j.jpba.2013.08.028. Epub 2013 Aug 30.

14.

NAALADase inhibition reduces alcohol consumption in the alcohol-preferring (P) line of rats.

McKinzie DL, Li TK, McBride WJ, Slusher BS.

Addict Biol. 2000 Oct 1;5(4):411-6. doi: 10.1111/j.1369-1600.2000.tb00209.x.

PMID:
20575858
15.

Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3.

Berent-Spillson A, Robinson AM, Golovoy D, Slusher B, Rojas C, Russell JW.

J Neurochem. 2004 Apr;89(1):90-9.

16.

Design of NAALADase inhibitors: a novel neuroprotective strategy.

Jackson PF, Slusher BS.

Curr Med Chem. 2001 Jul;8(8):949-57.

PMID:
11375762
17.

Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase.

Tolosa L, Mir M, Asensio VJ, Olmos G, Lladó J.

J Neurochem. 2008 May;105(4):1080-90. doi: 10.1111/j.1471-4159.2007.05206.x. Epub 2007 Dec 25.

18.

Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro.

Maragakis NJ, Rao MS, Llado J, Wong V, Xue H, Pardo A, Herring J, Kerr D, Coccia C, Rothstein JD.

Glia. 2005 Apr 15;50(2):145-59.

PMID:
15657939
20.

Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons.

Nakamizo T, Kawamata J, Yoshida K, Kawai Y, Kanki R, Sawada H, Kihara T, Yamashita H, Shibasaki H, Akaike A, Shimohama S.

J Neurosci Res. 2003 Feb 15;71(4):485-95.

PMID:
12548704

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